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Tag: "signaling" at medical news

C-Reactive Protein Induces Hypertension

...that the initiating mechanism is a lack of the key signaling molecule nitric oxide in the artery wall, which has multiple beneficial roles in the cardiovascular system, as well as made a connection between nitric oxide and the proteins responsible for angiotensin II activity. "Whether these same processes ar...

Researchers Identify Cell Pathway in Colon Cancer

...tein tyrosine phosphatase T regulates an important signaling pathway that is critical in cancer development. This identification will allow new approaches to pharmacological designs and facilitate alternative approaches for cancer treatment”, said Wang. With over 52,000 deaths each year, colon and rectal ca...

Smoking Alters the Human Brain Like Those in Animals Using Illicit Drugs

...studies between increased levels of these neuronal signaling enzymes in these brain regions and addiction-related behaviors. This strongly suggests that the similar changes observed in smokers and former smokers contributed to their addiction," he adds. Hope points out that although previous investigations o...

“Bridge” Protein Spurs Deadliest Stages of Breast Cancr

... deadly metastasis.” Feng, who studies molecular signaling in embryonic stem cells and examines signaling pathways that are involved in obesity and diabetes, has studied the roles played by Gab-2 and its ch...

Mouse Study Suggests Anxiety Disorders Take Root in Infancy

The absence of a key signaling protein in the brain during infancy could lead to anxiety disorders later in life, scientists say. //According to findings published today in the journal Nature, mice lacking the receptor protein for the chemical messenger serotonin just after birth ...

Bone Fragility, a Risk for Children With Cancer

...tion in general is regulated by a complex hormonal signaling network. Alter any one of the pathways and bone mineral density (BMD) may be changed. For example, osteoporosis is a complication among post-menopausal women for whom estrogen, a potent stimulator of bone formation, has decreased. External factors al...

New Imaging Technique Tracks Traffic Patterns of White Blood Cells

...on the surface of the cells in which receptors and signaling molecules accumulate during cell activation. Using digital multi-channel videomicroscopy, researchers were able to view white blood cell subsets and their forming microdomains in the vascular system in real time. In the upcoming March issue of Nature...

Discovery of Cell Pathway may Help Colon Cancer Patients

...tein tyrosine phosphatase T regulates an important signaling pathway that is critical in cancer development. This identification will allow new approaches to pharmacological designs and facilitate alternative approaches for cancer treatment." Source-Bio-Bio Technology...

Rare Mutation Causes Early Heart Disease and Metabolic Syndrome

...ngs indicate that altered activity of a well-known signaling pathway, Wnt, has large effects on multiple metabo...ation in a gene called LRP6, which acts in the Wnt signaling pathway and which was previously known to be involved in development and in certain forms of cancer....

Targeting SOCS-3 can Control Obesity

...e arcuate nucleus from taking part in an important signaling function that regulates appetite and body weight. Meanwhile, other portions of the weight regulation system remained intact and in fact became more responsive, thereby suggesting that arcuate nucleus function is the point of breakdown during leptin d...

Obesity And Environmental Chemicals: Research Probes Potential Link

...ls? “Everything I do has to do with how changes in signaling result in changes in gene expression,” she says. Carey’s work is at the cellular level. Isolating the fat tissue of these animals, Carey will explore the insulin sensitivity of fat cells. Preliminary data from her lab suggest that chronic exposure...

A Novel Treatment for KSHV-infected Lymphomas

...logues of cellular proteins, which engage cellular signaling pathways, govern cell proliferation and modulate apoptosis. Majority of the PELs appear to have an intact TP53 gene suggesting that genetic alterations are not selected for during PEL tumorigenesis. The results of this study demonstrate binding of ...

The Science of Happiness

...aired in individuals with Parkinson’s disease. The signaling chemical, dopamine , was christened the ‘pleasure chemical’. It was later established by Kent Berridge of the University of Michigan that the electrodes actually kindled desire, rather than pleasure. The dopamine system was found to control de...

Inflammation May Play Role in Metastasis of Prostate Cancer

...e disease. Karin and his colleagues discovered a signaling pathway that increased metastases in a mouse model of prostate cancer. The pathway is activated by a ligand that binds to a Receptor that Activates Nuclear factor Kappa-B (RANK). RANK ligand has been shown in previous studies to be an important infla...

Inflammation Promotes Metastasis of Prostate Cancer

... disease. Karin and his colleagues discovered a signaling pathway that increased metastases in a mouse model of prostate cancer. The pathway is activated by a ligand that binds to a Receptor that Activates Nuclear factor Kappa-B (RANK). RANK ligand has been shown in previous studies to be an important inf...

Genetic Pathways to Curable and Incurable Forms of Pancreatic Cancer Identified

...lls in this cancer also react differently to a key signaling protein, TGFb, which can induce cancer cells to change shape and become more mobile and invasive. It turns out that the cystic pancreatic cancer cells are resistant to these effects of TGFb and these types of cancers are also less likely to invade su...

'School Sermons' Need a Comeback

...gs, alcohol, or tobacco as more attainable markers signaling the transition to adulthood. "Young women who feel supported by their schools and confident about their future careers are less likely to view early parenthood as a way of finding meaning and gaining respect from their peers and communities." A...

Hepatic Stellate Cells Found Capable of Tissue Repair

...on in the liver, the researchers found that p75NTR signaling promotes the initial activation of HSC, which stimulates the proliferation of new hepatic cells to replace those that have been damaged. The effects of p75NTR at late stages of HSC activation and liver disease remain to be determined. "We were intr...

High-dose Inhaled Corticosteroid Use for COPD Could Cut Risk of Lung Cancer

...ine kinase inhibitors, and blockers or agonists of signaling pathways as reviewed. It is hoped, within the next decade, that chemoprevention of lung cancer in high-risk individuals (beyond smoking cessation) will be standard in pulmonary and primary care settings as is influenza vaccination or cardiac risk fac...

High Dose Inhaled Corticosteroid Use for COPD Could Cut Risk of Lung Cancer

...ine kinase inhibitors, and blockers or agonists of signaling pathways as reviewed. It is hoped, within the next decade, that chemoprevention of lung cancer in high-risk individuals (beyond smoking cessation) will be standard in pulmonary and primary care settings as is influenza vaccination or cardiac risk fac...

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