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Tag: "signaling" at medical news

Estrogen Curbs Appetite In Same Way as the Hormone Leptin

...hile the pathway of estrogen-induced intracellular signaling merges with that of leptin, estrogen’s effect on f...ptin or the leptin receptor. “Impaired estrogen signaling in the brain may be the cause of metabolic changes during menopause,” said Horvath. “Brain-selective...

A New Strategy to Control Breast Cancer

...ed. This also resulted in the inhibition of EGFR signaling and the reversion of malignant characteristics in ...ave designed an entirely new way of targeting EGFR signaling in breast cancer,” said Kenny. “Almost all the work to date has involved the use of antibodies that ...

Cocaine's Use During Pregnancy May Cause Lasting Cellular Effects

...of New York, we had previously shown a decrease in signaling of a particular receptor protein, the dopamine D1 receptor," Stanwood said. "We know that this receptor is involved in regulating the formation of cortical circuitry. It's also involved in the behavioral effects of amphetamines and cocaine.' 'The ...

Cocaine During Pregnancy can Cause Behavioral and Neurological Problems in the Child

...of New York, we had previously shown a decrease in signaling of a particular receptor protein, the dopamine D1 receptor,' Stanwood said. 'We know that this receptor is involved in regulating the formation of cortical circuitry. It's also involved in the behavioral effects of amphetamines and cocaine.' 'The c...

Secrets of the Heart's Signals

...ks on understanding the heart's natural electrical signaling process. The director of the Computational Cardiac...ed to understanding the heart's natural electrical signaling process and how it interacts with electric shocks delivered by a defibrillator in order to improve t...

Missing Molecule Has Important Role in a Developmental Brain Abnormality

A molecule that is part of a complex signaling network in the developing brain plays //a critical role in periventricular heterotopia (PVH), a congenital brain malformation, Yale School of Medicine researchers report in Neuron. PVH often leads to a variety of neurological disorders such as epil...

New Strategy for the Treatment of CML

...association with inactivation of multiple survival signaling pathways. Notably, enhanced lethality occurred in CML cells displaying various forms of imatinib mesylate resistance, said Grant. “While the development of newer, more effective kinase inhibitors such as dasatinib for diseases such as CML is a clea...

Tears Reveal Some of Their Deepest Secrets to Researchers

...nction for oleamide and related lipids in cellular signaling in the eye and in the maintenance of tear film,” s...urrently studying the role of oleamide in cellular signaling and communication in the eye, along with the role that the lipid may play in dry eye. “Dry eye is ...

New Ideas on Developing Thought-Controlled Artificial Limbs

...inked to the patient's thoughts, providing two-way signaling for motor control and feedback from multiple external stimuli." "We're at a junction now of developing a new approach for a brain-machine interface," says senior author Douglas H. Smith, MD, Professor of Neurosurgery and Director of the Center for ...

New Test Predicts CLL’s Sensitivity to Experimental Drug

...e brake. The drug molecules liberate the pro-death signaling molecules from their Bcl-2 captors. These pro-apoptosis molecules -- a key one is called BIM -- then trigger a chain of events that cause the cell's power plants, or mitochondria, to rupture and spill out chemicals that cause the cell to die and be t...

A Protein in Brain Cells Controls Obesity: Research

...regulates body weight, the action of the metabolic signaling molecules leptin and insulin, and the use of energ...nce is linked to alterations in leptin and insulin signaling that lead to excess weight gain and Type 2 diabetes, respectively,” says Rui, an assistant professor...

Researchers Investigate Gene Linked With Circadian Liver Clock

... expression. These and similar questions about the signaling pathways that bring all the body’s clocks into the same phase can be explored with the novel transgenic mouse model described here. Source-Eurekalert<BRSRI...

How Bloods Vessels are Linked Together?

...functions during the formation of blood vessels by signaling via receptors on the surface of the endothelial cells, the specialised layer of cells on the interior surface of the blood vessels. Swedish scientists at Karolinska Institutet and the biotech company AngioGenetics AB have now shown that another fac...

Vagus Nerve and Diabetes

...y have surgically implanted devices that alter the signaling of the vagus nerve. Some people with seizure dis... hypertension. "We used surgery to interrupt all signaling from the vagal nerve pathway," Bernal-Mizrachi says. "But it might actually be possible to change ve...

New Treatment For Psoriasis Is Highly Effective

...other immune mediated diseases that share the same signaling pathways, specifically inflammatory bowel disease ... that therapeutics that target the IL-12 and IL-23 signaling pathway appear to effectively treat both psoriasis and IBD,' he said. According to Krueger, the s...

Antibodies in Mother Affect Heart of Fetus

...or before birth and impairs the heart's electrical signaling from the upper to the lower chambers. CHB carries a 20 percent death rate and nearly all survivors require pacemakers. Joshua Copel, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale helped conduct the PR Int...

Natural Brain Substance Linked to Parkinson's Symptoms

...sease patients. The shortage arises when another signaling system in the brain, driven by the neurotransmitte...ngredient in the plant that mimics the brain's own signaling compound. That has potent effects but there's no evidence it can help problems in the dopamine-endoc...

Genetic Test for Type II Diabetes Moves Closer

... the pancreas and liver and is a target of the Wnt signaling pathway, as is TCF7L2. Two previous studies into the role of IDE in the onset of Type II diabetes indicated a weak association, which was not confirmed by a third study. Further mapping of the IDE-KIF11-HHEX loci in different populations as well as...

New Drug Promises Prolonged Survival in Prostate Cancer Patients

...of these growth factors activates an intracellular signaling pathway that leads to tumor proliferation. While other drugs such as docetaxel have shown to benefit men with advanced prostate cancer, no other second-line therapy (a treatment given when an initial treatment (first-line therapy) does not work or ...

New Drugs Shows Promise in Slowing the Progression of Prostate Cancer

...of these growth factors activates an intracellular signaling pathway that leads to tumor proliferation. While other drugs such as docetaxel have shown to benefit men with advanced prostate cancer, no other second-line therapy (a treatment given when an initial treatment (first-line therapy) does not work or...

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