signaling 1 6

Tag: "signaling" at medical news

Low Doses Of Arsenic Have Broad Impact On Hormone Activity – Says A Researc

...s. Chemicals that disrupt steroid hormone receptor signaling are called endocrine disruptors, and this study pr...e complex biological effects of arsenic on hormone signaling at different doses will be critical to our overall understanding of how arsenic influences human hea...

How Taste-buds Develop?

...enetically engineered mice, they discovered that a signaling pathway activated by small proteins called Wnts is...he basis of taste-bud development in humans. The signaling pathway activated by Wnt proteins is critical to the development of many organ systems, and its inap...

A New Rapid 3-D Cell-Growth Technique For Growing Heart Muscle

...ta-adrenergic receptors. Both are important to the signaling required to produce cohesive action by cells in tissue. The U-M team also assessed the BEHM's structure and function at different stages in its development. First author and postdoctoral fellow Yen-Chih Huang, Ph.D., of the U-M Division of Biomedi...

Vulnerability to Ear Infections Lessened by Breast Feeding

...in three important genes that produce inflammatory signaling molecules for the immune system," said lead author... detected cause greater production of inflammatory signaling molecules and reduce immune system effectiveness. But the UTMB scientists found that the effect coul...

Tailor-made Cancer Treatment for Multiple Myeloma Patients Offered by Mayo Clinic

...asome cause a buildup of proteins that affect many signaling cascades (various necessary biological processes). Bortezomib was initially thought to exert its activity by disrupting one of two known NF-êB (Nuclear Factor kappa B) pathways which keep cancer cells from self destructing the first-discovered, or ca...

Study Explains How NSAIDs Halt Cancer Growth

... for example, inflammatory bowel disease – certain signaling pathways that modulate the inflammatory processes become “stuck” in an activated state. Among other outcomes, this course of events leads to the release of molecules that enhance carcinogenesis and tumor progression at the site of the damage. Accor...

Drug Treatment Slows Macular Vision Loss in Diabetics

...ile that ranibuzumab’s ability to shut down VEGF’s signaling would do the trick because it’s highly likely that VEGF is the culprit when it comes to diabetic macular edema,” says Nguyen. More than 4 million diabetics in the United States have diabetic retinopathy and, according to the National Eye Institute,...

Study Identifies Mechanism Which May Help Tamoxifen Work Better

... pathway while simultaneously controlling estrogen signaling through the estrogen receptor,” said Albain, director, thoracic oncology clinical research program; director, breast clinical research program; and co-director, multidisciplinary breast oncology center; Loyola University Health System, Maywood, Ill. ...

Durable Critters Provides Better Way to Human Egg Preservation

...single sperm penetrates, it triggers intracellular signaling that transforms the coat into a hard, impermeable ...e jelly coat, cold stress can change intracellular signaling resulting from sperm penetration. Lipids or fats in the egg can fuse and the membrane can become lea...

Breast Cancer Stem Cells Appear Resistant to Radiation Therapy

...is to be due to radiation, which could titillate a signaling pathway, giving the message to stem cells, to reactivate and grow. Scientists opine that cells may comprise of an inborn radiation protectant, which is capable of offsetting radiation propelled DNA damage which is the reason behind the death of breas...

Cellular Cues Identified for Stroke Recovery

...e model, this neuron march is the direct result of signaling from the newly blooming blood vessels, thus casually linking angiogenesis the development of new blood vessels and neurogenesis, the birth of new neurons. Further, they have identified what these molecular signals are. The results hold promise for ev...

Molecular ‘On/Off Switch’ Controls Immune Defenses Against Viruss

...oducing a protein called a protease to disrupt the signaling process, preventing interferon production and allowing viral replication. Just how RIG-I signaling is normally regulated, however, hadn’t been known. In the current study, UT Southwestern researche...

Glucose Sensor That Controls Glucose Metabolism Identified

...s. This discovery, Saez said, represents the first signaling pathway where a carbohydrate activates a nuclear receptor, although the precise mode of binding remains unknown. As part of the study, mice were put on exclusive sucrose or D-glucose diets; all diets were devoid of cholesterol to minimize naturall...

Regrowth of Zebrafish's Tail Fin may Offer Clues for Treating Human Injuries

...on laboratory evidence that suggests that Wnt/Beta signaling also promotes the regeneration of tail fins in zebrafish. Another, distinct signaling pathway activated by a different kind of Wnt protein called Wnt5b, turns down the genes that are tur...

Sex Ends as Seasons Shift and Kisspeptin Levels Plummet

...e reproductive switch even in the presence of cues signaling a winter, non-breeding environment. "What is really striking is the disappearance of kisspeptin in animals experiencing winter-like days, yet the ability to respond to kisspeptin when we provide it," said Timothy Greives, lead author of the study....

How Many Genes Does It Take to Learn? Lessons from Sea Slugs

... data on gene transcripts associated with neuronal signaling pathways in Aplysia that sheds new light on evolutionary relationships of this very ancient and highly successful marine animal," said Dennis Steindler, Ph.D., executive director of UF's McKnight Brain Institute, who did not participate in the resear...

Potential Key to Brain Blood-Flow Disorders Explored by Scientists

...science. The cellular process is responsible for signaling regional blood flow changes in the brain. To funct...ytic BK channel is an important participant in the signaling mechanism. The teams next needed to uncover how the muscle cells responsible for determining blood...

Estrogen Curbs Appetite: Research

...hile the pathway of estrogen-induced intracellular signaling merges with that of leptin, estrogen's effect on f...eptin or the leptin receptor. "Impaired estrogen signaling in the brain may be the cause of metabolic changes during menopause," said Horvath. "Brain-selective...

Researchers Investigate Molecular Basis of Memory

...crucially involved in learning and singled out the signaling pathway through which it affects memory. Phone n... TrkB, which is incapable to activate an important signaling pathway involving the protein PLCg, were no longer able to learn. At the same time the LTP that norm...

Study Finds Astaxanthin Is Potent Inhibitor of Oxidation in Cell Membrane Model

...lance (i.e. redox status) of mitochondria and cell signaling pathways upstream from the point that produces activation of bioactive inflammatory mediators. "These data clearly demonstrate a differentiation within the carotenoid class of medically promising antioxidants and provided, in part, the impetus for C...

1 2 3 4 5 6 7 8 9 10