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Tag: "signaling" at medical news

Study States That CNS Could Regulate Arthritis

.... The UCSD research team found that blocking key signaling enzymes in the CNS of rats resulted in decreased j... therapeutic targets by blocking the function of a signaling enzyme called p38 MAP kinase throughout the body. This enzyme regulates cytokines proteins released ...

Hormone Could Be Answer To Atkins' Diet Success

...found that a hormone called PYY is responsible for signaling the brain that hunger has been overcome after a meal rich in proteins. "People on the Atkins diet don't feel as hungry - that's how it works," Batterham said. The researchers also investigated in mice and genetically modified them to inhibit PYY pro...

Nitric Oxide Levels In Brain Indicate Sleep

...e promotes sleep is by stimulating production of a signaling molecule called cyclic GMP, and it may be possible to achieve the same effect by using drugs that block cyclic GMP's breakdown, Rosenberg says. One surprise in the research was that the main message telling the brain to go to sleep probably does no...

Techniques for analyzing protein interactions aid in detecting the molecular basis of diseases

...tance of characterizing the molecular networks and signaling pathways that form the biological basis of all living organisms, techniques aimed at probing protein interactions have come to the forefront in recent years. The new methods published today by CSH Protocols will be useful for researchers seeking to i...

Protein Increase Decreases Risk of Heart Failure

... newly discovered link between a certain molecular signaling pathway and changes in S100A1 levels in the heart after heart attack. Certain cell receptors called Gq-coupled receptors, which include alpha-adrenergic and angiotensin receptors, play a role in cardiac hypertrophy and "have been implicated in bein...

Study Unveils West Nile Virus Immune Evasion, Points to Vaccine Development

...ades the body’s immune defenses by blocking immune signaling by a protein receptor, a finding that could pave t...s strain can inflict illness because it blocks the signaling activity of a protein receptor called the interferon alpha/beta receptor, or IFNAR, disrupting a cel...

Eating Strawberries may boost memory

...ies// and other fruits and vegetables, invigorates signaling pathways that boost long-term memory. This study...nections between nerve cells." Interestingly the signaling pathway activated by fisetin in neural differentiation also played a role in memory formation, a pro...

Pick Apples for Good Neurological Health, Says New Research

...r kappa B pathway” (this pathway involves chemical signaling between cells). The UC Davis research revealed that apple extract protected the cells from the normally lethal effects of TNF by interfering with this pathway that would otherwise damage or kill cells in the body. Gershwin noted that the method by wh...

Cell Wall of Pneumonia Bacteria Can Cause Brain and Heart Damage

...atelet activating factor (PAF) is an immune system signaling molecule that activates certain white blood cells. It normally binds to PAFr on the cell lining. The St. Jude team demonstrated that phosphorylcholine, a molecule on the bacteria’s cell wall, resembles PAF and exploits this similarity to bind to PAFr...

Systemic Pre-Surgical Treatment Can Prolong Survival Of Kidney Cancer Patients

...esearchers looked at the protein expression of key signaling molecules involved in controlling cell proliferati... treated group, which meant that blocking the VEGF signaling pathway with bevacizumab might have resulted in feedback to the AKT pathway, which is known to be in...

Effect Of Growth Factor Signals On Cancer Development

...e development of cancer. //If the concentration of signaling protein called insulin-like growth factor-I (IGF-I...uts the brakes on cancer. The interplay of the two signaling pathways reinforces questions about the long-term risks of prescribing growth hormone and IGF-I to p...

"Trojan Horse" Agent Halts Bone Metastasis in Mice

...pment of tumors in bone, says Rosenblum. VEGF is a signaling protein involved in the creation of new blood vessels, but in this study the researchers found that it plays a surprising role in the remodeling of bone tissue. In the normal maintenance of bones, a balance exists between activity of cells known as...

Limb Regeneration Exists Innately In All Vertebrates – Says Researc

...eneration is under the control of the powerful Wnt signaling system: Activating it overcomes the mysterious bar...generate, but grew scar tissue. Manipulating Wnt signaling in humans is, of course, not possible at this point, Belmonte says, but hopes that these findings ma...

Scientists Pursue New Treatment For Asthma Sufferers

...icro environment” by stimulating production of the signaling cytokines. Involved in triggering the body’s immune defense mechanism to take action against infection, cytokines are responsible for almost all the characteristics of asthma. “If cytokines are produced in the lungs, you’ll end up with asthma,” sa...

Zinc – A New Key Player In Brain Circuitr

...the multitude of substances that regulate neuronal signaling in the brain and spinal cord – says the research. ...demonstrated a central role for zinc in modulating signaling among the neurons. Significantly, they found the mutant mouse shows the same exaggerated response to...

Blame Myelin for Many Neuropsychiatric Disorders

...rugs that are known to improve a neuron’s synaptic signaling in people who suffer diseases like Alzheimer’s. Fu...e better the myelin, the more efficient the neuron signaling and our “Internet’s” function. Specifically, such cholinergic treatments may enhance oligodendrocyte...

Germ - Chemo Combo Fights Cancer

...-poor core of mouse tumors and the blackened scars signaling that most of the cancer cells had been destroyed. Normal surrounding cells were largely unaffected. But the bacteria failed to kill cancer cells at the still oxygen-rich edge of the tumors. In response, the Hopkins team added specially-packaged che...

Prestigious Wilson Award Goes To Yale Cell Biologist Joel Rosenbaum

...chano-receptors in the ciliary membrane. Through a signaling pathway, the calcium represses cell division,” sai... dividing start to divide because of a defect in a signaling pathway starting at the cilium” This sensory role of primary non-motile cilia has now become the mo...

Violent Video Games Leave Deep Impressions in Brain

...o games showed a definite change in the MRI image, signaling a significant arousal in emotional level. Also the area that controls focus, concentration and self control showed a depression.The children who were not allowed to watch violent clippings did not show any such changes. These studies definitely poin...

Enzyme to Boost Effect of Tumor Vaccine

...ar domain on the plasma membrane of the cell where signaling occurred, making the action of Akt1 more specific. They then eliminated a small part of the Akt1 molecule that had a negative or inhibitory effect. 'It turned out that the altered molecule was much more potent,' Spencer said. He credited graduate stu...

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