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Tag: "signaling" at medical news

Scientists Identify New Possible 'biomarker' for Pancreatic Cancer

... this disease and cancer metastasis. Clearly, this signaling pathway is associated with pancreatic cancer and merits further investigation," Waltz said. During the study, the researchers used the protein HGFL to activate the RON receptor. They observed that though stimulating the RON receptor had no effec...

Loss of Antenna Leads to Cancer in Insects

...searchers describe the strong link between ciliary signaling and cancer and identify the rogue engineers respon...lly. Many cancers arise from defects in cellular signaling systems, and we think we have just identified a really exciting signaling connection, Fox Chase Canc...

Chronic Metamphetamine Abuse is Related to Cardiovascular Disease

...ascular endothelial growth factor (VEGF), a potent signaling cytokine involved in angiogenesis and vasodilation. Our data suggest that even methamphetamine use at lower doses may be enough to increase VEGF to potentially detrimental levels, Janda said. In addition to Janda and Dickerson, both of Scripps Res...

Research Studies on Molecular Switches of Gene

... depending on which tissues are using it and which signaling molecule caused cAMP to put CREB to work, Brindle said. It is another clue to how CREB might activate the genes for enzymes that make glucose in the liver, while activating different genes in the brain that are key to learning and forming memories. ...

Neurological Disorder Gene Identified

...iences Institute, found that the mutation caused a signaling molecule, called PI(3,5)P2, to be under-produced in both yeast and mice cells. This little-studied signaling molecule was known to be present in yeast cells but has not been well studied in mammals. The rese...

Protein Pathway Involved in Parkinson Disease Development Identified

...1 mutations on the mitochondria and how this novel signaling pathway is disrupted in the development of Parkinson disease," says Lian Li, PhD, associate professor of pharmacology in Emory University School of Medicine and research team leader. Dr Li says that these new findings show how the mutations affect ...

Key Signaling Molecules in New Teeth Formation Identified

Xiu-Ping Wang and colleagues identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche, using a combination of mouse mutant analyses , organ culture experiments, and gene expression studies, although mammals have a limited capacity to regenerate teeth, mo...

Parkinsons Disease Protein Pathway Identified

...of Emory University scientists have found a novel signaling pathway in cells that is altered by genetic mutati...1 mutations on the mitochondria and how this novel signaling pathway is disrupted in the development of Parkinson disease," says Lian Li, PhD, associate professo...

Sensible Diet, Exercise and Weight Control Increases Longevity

... School. White speculated that the insulin-like signaling pathway in the brain might promote age-related brain diseases. We are beginning to appreciate that obesity, insulin resistance, and high blood insulin levels are connected to Alzheimers disease, Huntingtons disease, and dementias in general, he sa...

Eap1 in the Brain Regulates the Female Reproductive Cycle

...secrete gonadotropin-releasing hormone (GnRH). How signaling to these neurons is controlled remains unclear. ...berty 1 (EPA1) acts as a regulator of the neuronal signaling that controls female reproductive function. The authors found that EPA1 expression was selectively ...

Insulin Sensitizer- Energy Conserving Signal to Brain

...rgan that secretes a number of biologically active signaling proteins, called adipokines. Adiponectin, an adipokine secreted exclusively by WAT, is present at relatively high concentrations in the circulation and has been shown to increase the bodys response to insulin. Studies have also suggested that dec...

New Cancer Therapy in Clinical Trial

...d apoptosis-inducing ligand (TRAIL) death receptor signaling an attractive and exciting target for cancer thera...in a better understanding of TRAIL-associated cell signaling pathways in cancer cells and to look for ways to pharmacologically optimize TRAIL therapy. Dr. El-...

Amorous African Fish Exchange Electric Pulses While Mating

... and custom software, both observed the electrical signaling and physical behavior of the fish. Wong, who de...ication. The new study suggests that electrical signaling may have been shaped in part by sexual selection, the evolutionary process responsible for many anim...

Specific Protein is Instrumental in Myelination

...rated conclusively that a specific protein and its signaling activity are instrumental in myelination and remy...se models to identify an essential protein and its signaling activity in the processes of myelination and remyelination. These processes are relevant to white ma...

Gene Variation Increases the Risk of Lung Cancer

...n genes for interleukin 1A and interleukin 1B, two signaling molecules that immune system cells secrete in response to infection or tissue damage. Our findings help explain how heavy smoking, for example, combines with a genetic predisposition to create a besieged environment within the lungs, said lead auth...

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