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Tag: "sequenced" at medical news

Structure of TB Enzyme Points the Way to New Drugs: Study

... 491 protein kinases that have been identified and sequenced thanks to the mapping of the human genome. "Since we now know exactly what the requirements should be for a good blocker and how to avoid interference with host kinases, we should now be able to rationally design compounds that are highly effective...

Size and Position of Floral Anther Plays a Vital Role in Pollination

...duced conflicting results, but as more genomes are sequenced and the functions of numerous genes studied, both zoologists and plant biologists have begun to understand that gene sequences alone cannot explain diversity. Within the last few years, scientists have begun to identify groups of genes, called netw...

Evolution of HIV from African Greek Monkeys

...rigorous test of that hypothesis." He extensively sequenced the mitochondrial DNA genes of the four species of African green monkeys. Mitochondrial DNA is passed from mother to child. The four green monkeys he studied are the sabaeus monkey, Chlorocebus sabaeus, which lives in western Africa; the tantalus m...

Genome Annotation by Mutation

...mutated. Because the whole mouse genome has been sequenced the order and location of base pairs determined in detail scientists can identify locations in individual mice where the jumping genes have carried pieces of loxP DNA. Then, they can select a mouse with loxP on both sides of the large piece of DNA ...

Ancient Viral Defense may Explain Susceptibility to HIV: Study

...anzee genome. In fact, when the chimp genome was sequenced in 2005, it emerged that the largest difference between chimp and human DNA was the presence of PtERV1. Researchers at the Fred Hutchinson Cancer Research Center in Seattle, Washington, were intrigued by the disparity and speculated that the reason t...

Boffins a Step Closer to Solving Puzzle of Lou Gehrig's Disease

...ll damage. The link with ALS came when researchers sequenced the genes of people who have the inherited form of ALS and found that some of them have mutations in the gene that codes for this enzyme. While the inherited form represents only a fraction of all ALS cases, this marked the first time there was any i...

Cataloging the Structural Variations in Human Genetics

...for each person. The ends of the segments are then sequenced to uncover evidence of structural variation. Whene... such evidence is found, the entire DNA segment is sequenced to catalog all of the genetic differences between the segment and the reference sequence. The res...

Scientists Map Genome Sequence Dengue Mosquito

...equencing DNA in chromosomes, scientists have also sequenced large amounts of messenger RNAs collected from different mosquito tissues at distinct developmental stages. Matching a messenger RNA to a predicted gene will validate authenticity of this gene," he explains. Zhijian Tus team has uncovered and descr...

Genome of Botulism Bacterium Revealed

...C. botulinum genome are absent from the other five sequenced clostridia, and only 16% of the C. botulinum genes are common to all five. Our findings emphasise just how different clostridia are from each other." C. botulinum toxin stops nerves from working - the basis of its use in medicine to control tremors...

A New Target for Cancer Therapy-Integrin Alpha7 Molecule

...ontribute to cancer, Dr. Luo and his collaborators sequenced the integrin alpha7 genes from 66 human cancer specimens and cell lines representing a number of different kinds of cancer, including cancer of the prostate, liver, brain (glioblastoma) and muscle (leiomyosarcoma). They found mutations in the integ...

Ovarian Cancer May Mimic Fallopian Tube Formation

...sk of cancer biologists,” he said. “Now that we've sequenced the human genome, we have to make sense out of the thousands of genes that are expressed in cancer at the same time.” This research was supported by grants from the Georgia Cancer Coalition and a gift in remembrance of Josephine Crawford Robinson f...

India Finds New Use for an Old Bug

...nces (AIIMS) in New Delhi. "Because we have not sequenced any genome so far, we decided to sequence Mw that was discovered in India," says Syed Hasnain, formerly director of the Centre for DNA Fingerprinting and Diagnostics (CDFD) in Hyderabad, one of the three laboratories involved in the sequencing projec...

Breeding success by delving into the honey bee sex gene

...igan State University and the University of Kansas sequenced csd genes from individuals in three closely relate... bees Apis dorsata and Apis cerana. The group also sequenced six so-called neutral regions of the genome which, unlike genes, do not carry codes telling cells ho...

NHGRI Aims To Sequence Primate Genomes

...work and their international partners have already sequenced – or have been approved to sequence – at high-dens... mammals which have been previously approved to be sequenced at low-density genome coverage have been targeted to now be sequenced at high-density genome coverag...

Humans, A Symbiotic Organisms Dependent On Other Life Forms For Existence

...e them with essential functions. Gill and his team sequenced the DNA in faeces that were donated by three adults and found that a surprising amount of it came from bacteria’s. They compared these gene sequences to known bacteria’s and to the human genome and they found that almost the entire amount of genetic ...

The Novel Cut and Splice Method Is Used To Recognize Different Microbes

...gments of genetic code that are short enough to be sequenced rapidly and can readily distinguish among species. The Brookhaven team has developed the single point genome signature tagging. Enzymes that recognize specific sequences in the genetic code are used to chop the microbial genomes into small segments...

New Study Questions Cannibalism As A Worldwide Selective Force

... human history. Bertranpetit and his colleagues sequenced 2,378 base pairs of the PRNP gene in 174 individuals; in addition, they genotyped two SNPs from the PRNP gene in 1000 individuals from populations worldwide. They identified 28 different haplotypes - or combinations of DNA variants - in the PRNP gene...

PA-824 drug effective against Tuberculosis

...s found to be resistant to PA-824. The researchers sequenced the entire genome of the Mycobacterium tuberculosis to find the mutations in the Mycobacterium tuberculosis leading to loss of two proteins FGD1 and F420 or changes in these proteins which is responsible to the resistance of the bacterium to the drug...

H-ras gene mutation linked to Costello Syndrome

...performed DNA sequencing. When possible, they also sequenced the genes of the patients' parents. The nature of the missense mutations, along with the paternal age effect observed in Costello syndrome suggests a paternal origin of the mutations, the researchers report. Source: Eurekalert...

New advance in prostate cancer management

... cancer and breast cancer) has been identified and sequenced by the members of the institute. In addition, the institute has also developed 'conformal radiotherapy' which allows higher doses of radiation to be targeted directly at tumors....

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