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Tag: "selectively" at medical news

A Novel Treatment for KSHV-infected Lymphomas

...r Nutlin-3a disrupts the p53-MDM2-LANA complex and selectively induces massive apoptosis in PEL cells. The cytotoxic effect of Nutlin-3a was specific for the KSHV-infected cells since Nutlin-3a did not induce apoptosis in lymphoblastoid cell lines transformed with another human tumor virus, the Epstein-Barr viru...

Wiping Out Memories Selectively, is Possible Now

It could be possible to wipe out memories selectively from the human brain. Researchers are now emboldened on this front, as they have been able// to wipe out a single specific memory from brains of rats using a drug, leaving all other recollections intact. If that experiment can be successfully repl...

J591- an Antibody Exclusively Targets Tumors

...591 armed with a drug or radiation offers a way to selectively target cancer while leaving healthy tissues unharm...ce tumor size), researchers now have a vehicle for selectively transporting drugs or a radioactive isotope to destroy the blood vessels that feed tumors, thereby c...

Natural Antibiotics Yield Secrets to Atom-level Imaging Technique

..., punching holes into their membranes. But they're selectively pugnacious, targeting microbes but leaving healthy host cells alone. "They're like smart bombs," Ramamoorthy said. "We'd like to exploit their properties to design super-smart bombs, but before we can do that, we need to understand how these AMP sm...

Sea Creature's Toxin Could Lead to Promising Cancer Treatment

...effect. “That the diazonamide toxin blocks mitosis selectively in cancer cells is almost too desirable an outcome to be true,” said Dr. Steven McKnight, chairman of biochemistry and senior author of the second study. “As with any other unanticipated scientific discovery, the validity of these observations will b...

Researchers On The Path To Building Bone

... be possible. “The key will be to find a way to selectively turn off Pten only in bone-making osteoblasts and leave other cells in the body unaffected,” Clemens said. “Pten plays an important role in the body by killing cell lines that are proliferating out of control, as in tumors.” Source-Newsise SRM...

A Novel Technique Nudges Genes Into Activity

...atural tumor suppressors, and using this method to selectively activate those genes might help the body fend off cancer, Dr. Janowski said. Genes are segments of DNA housed in chromosomes in the nucleus of every cell and they carry instructions for making proteins. Faulty or mutated genes lead to malfunctionin...

Sensible Diet and Good Exercise is the Key to Lose Weight

...uring exercise and dieting, one cannot lose weight selectively on the abdomen or on the thigh. Body metabolism also cannot be improved by adding muscle mass. When it comes to energy deficit, it plays a vital role in the abdominal fat, body weight and fat weight. Ravussin used this study to find out if dieting ...

Sugars in Liver Found to Clear Fats from the Bloodstream

...th of an embryo or death shortly after birth. “By selectively mutating a single tissue in mice, in this case the liver, we avoided a lethal effect,” said Esko. In the lab, the researchers combined the heparan sulfate mutation with a mutation in the LDL receptor, which has long known to be responsible for cleari...

Study Offers Window into Human Behavior, Brain Disease

...rons that are involved in social behavior that are selectively vulnerable in the second major degenerative disorder." Notably, VENs are located in regions of the brain that are in a good position to transmit raw emotional signals to other brain centers. In addition, VENs have characteristics that suggest they...

Genetically Modified Cells Attack Tumors

...ersed throughout the mice but was activated by rCE selectively at the neuroblastoma tumors. The researchers used the rabbit form of this enzyme because it activates CPT-11 much more efficiently than the human version, Danks said. This activation is essential to treatment because the activated form is up to 1,000...

"Trojan Horse" Agent Halts Bone Metastasis in Mice

...by the researchers have shown that the protein can selectively destroy blood vessels feeding human solid tumors. In this study, investigators implanted human prostate cancer cells, which are highly metastatic to bone, directly into the leg bone marrow of experimental mice in order to simulate a bone metastasis...

Strong Evidence Suggests Incidence Of Mating Of Ancestors With Neanderthals

...ir strong and dynamically dominant gene pool which selectively aids evolution of the species without any inter breeding whatsoever. Earlier in a similar research Dr. Lahn and his associates had discovered a gene which determines the size of the brain named microcephalin which seems to have undergone a conspicuo...

Diptheria Toxin And Interleukin2 Help Killing Melanoma Tumour Cells

.... 'We thought that if denileukin diftitox could selectively deplete Tregs in patients with melanoma, this would allow the CD8+ T cells to do their job of recognising and attacking the melanoma cells,' said Dr Chesney. Dr Chesney and his colleagues gave seven patients with stage IV melanoma nine or twelve mi...

First Major Study of Mammalian “Disorderly” Proteis

...es in the cell,” Kriwacki said. “Our new technique selectively concentrates the IUPs that are involved in regulating functions in the cell and transmitting signals within them.” Unlike the classic description of proteins described in science textbooks, IUPs are not completely locked into rigid, 3-D shapes that...

Clues to the Mystery of Lou Gehrig's Disease

...ating in the progressive degeneration of different selectively vulnerable neurons." Dr Lee said, "It's very exciting that we finally made the connection between dementia and motor neuron disease. Clinically there's overlap in these two disorders, so it was very tantalizing to see if there was anything to link ...

Super Chow, Laced With Semi-Synthetic Vitamin E, Inhibited Spread of Cancer

... they show amazing anticancer properties, and they selectively target tumor cells,” Akporiaye said. To make the synthetic vitamins water soluble (not fat soluble like natural vitamin E), researchers have added sodium hydroxide. In this way, these vesiculated forms, called V?-TOS and Valpha-TEA, can be delivere...

Nobel Prize for Gene ‘Silencing

...re thousands of genes in our genome, but they are selectively expressed to produce the mRNA through a process called ‘transcription’, which is regulated by several factors. The information coded in the DNA is carried via the messenger or mRNA to the cytoplasm to be transformed into proteins. This basic infor...

New Angiogenesis Finding May Help Fight Cancer Growth

...timulated angiogenesis," Bresnick says. In theory, selectively stimulating angiogenesis could help treat heart attacks by restoring blood flow to the heart, increasing the blood supply to threatened heart muscle. NK-B also plays a role in a mysterious but common syndrome called preeclampsia, in which soaring b...

Gene Transfer Using Mutant Form of Good Cholesterol Cuts Vascular Plaque and Inflammation

...he genes into the bone marrow. The signal molecule selectively goes into immune system cells called macrophages, which go into the arterial wall. “We examined the ability of both the wild type and the apo A-I Milano gene to move cholesterol out of the macrophages, a process called cholesterol efflux. This is o...

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