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Tag: "selectively" at medical news

A new century of Alzheimer's disease research

...rking to prevent the development of Alzheimer’s by selectively inhibiting production of AB42. Still, Drs. Golde and Koo realized that, regardless of how NSAIDs might be working to decrease the risk of developing Alzheimer’s, conducting clinical trials of NSAIDs in populations at risk for Alzheimer’s or in thos...

Chemical Injections for Fat Removal

...s and fat cells themselves. In order to add fat selectively to the mice they tested, researchers injected NPY into a specific area. The researchers found that both NPY and Y2R are activated during stress, leading to apple-shape obesity and metabolic syndrome. Both the weight gain and metabolic syndrome, howev...

EpiCept Accelerates Development of Phase I Clinical Study for Cancer

... has been shown to induce tumor cell apoptosis and selectively inhibit growth of proliferating cell lines, including multi-drug resistant cell lines. Murine models of human tumor xenografts demonstrated EPC2407 inhibits growth of established tumors of a number of different cancer types more effectively than the ...

Scientists Discover Key to Manipulating Fat

...sels and fat cells themselves. In order to add fat selectively to the mice they tested, researchers injected NPY into a specific area. They found that both players are activated during stress and lead to obesity and metabolic syndrome. Administration of Y2R blocker into the abdominal fat prevented both condition...

Kids With Crohn's Disease are at Ease Now

...tem suppressors and antibiotics. Biologic agents selectively target key inflammatory processes involved in the development of a disease in this case infliximab blocks the bodys inflammation response. Its side-effects can include upper respiratory infections and other potentially serious reactions. The Al and...

New Cancer Fighting Virus

...a type of herpes simplex virus modified so that it selectively replicates in virus cells, killing them in the process. It doesnt replicate in normal, healthy cells, so our hope is that it will help fight cancers without causing side-effects in the rest of the body, said Dr. Axel Mescheder, VP Clinical Research...

Gene Therapy Eradicates Pancreatic Cancer in Mice

...ical trials that a molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumours, inhibits metastasis, and prolongs survival virtually without toxicity. "This vehicle, or vector, is so targeted and robust in its cancer-specific expression that it can be used...

Scientists Find New Way to Kill Antibiotic-resistant Bacteria

...ay. "Our discoveries may lead to the ability to selectively kill antibiotic-resistant bacteria in patients, and to halt the spread of resistance in clinical settings," said senior study author Dr. Matt Redinbo, Professor of Chemistry, Biochemistry and Biophysics at UNC-Chapel Hill. Almost every type of bact...

Researchers Develop First Mouse Model of Lung Transplantation

...are easier to manipulate. With the mice, we can selectively delete genes to study their function in the transplanted lung or in the recipient, which weve not been able to do effectively in other animal models, said Andrew Gelman, Ph.D., an assistant professor of surgery, who is a lead investigator of this res...

Cell Toxin Inhibits Survival Protein in Cancer Cells

...ecies of invasive fish in lakes has been found to selectively inhibit two "survival proteins in cancer cells. ... to look for small molecules or compounds that are selectively toxic to cells that over express Bcl-2 proteins. Higher expression of the target protein made cell...

Eap1 in the Brain Regulates the Female Reproductive Cycle

...ction. The authors found that EPA1 expression was selectively increased at puberty in the hypothalamus in monkeys, rats, and mice. They also showed that the protein product of EPA1 was expressed in neurons involved in the control of reproduction, and that EAP1 activated GnRH. The authors went on to show that ...

Natural Selection in Butterflies

...bacteria, which is passed down from the mother and selectively kills males before they have a chance to hatch. ...serve." The researchers noted that bacteria that selectively kill male offspring are found among a range of arthropods, so what was seen in this study may not be...

Alien Hand Syndrome Causes Random Hand Movement

...esearchers found that the primary motor cortex was selectively activated, with more activity as AHM increased. Voluntary movements also activated the primary motor cortex, but other regions of the brain were activated as well. Voluntary movements with either hand showed significant activation in the contralat...

Weizmann Researchers Developed Control Switch for Protein Activity

...n. This segment is capable of binding strongly and selectively to a particular chemical drug, which affects the activity level of the engineered protein by increasing or reducing it. When the drug is no longer applied, or when it is removed from the system, the protein returns to its natural activity level. As...

FDA Approves INTUNIV (guanfacine) for the Treatment of ADHD

...rst medication indicated to treat ADHD symptoms by selectively targeting alpha-2A-receptors in the prefrontal cor...uanfacine, the active ingredient in INTUNIV, binds selectively to alpha 2A adrenergic cell receptors located in the part of the brain called the prefrontal cortex....

The Bottleneck in Neuroblastoma

...ve isotopes that zero in on neuroblastoma cells to selectively kill those cells with radiation. Other tools include retinoids--biological molecules that hone in on cancer cells, angiogenesis inhibitors that cut off a tumor's blood supply, and tyrosine kinase inhibitors that interrupt a critical step in the tum...

Untreatable Eye Disease Improves With Avastin

...nhibits the formation of abnormal blood vessels by selectively blocking a substance known as vascular endothelial growth factor (VEGF). Avasitin (also called bevaciaumab) is used systemically (throughout the body) for some cancers and has been linked to the risk of stroke; but, in this new study, it was administ...

Two MSU Professors Spearhead International Water Project

...based technologies. Membrane-based technologies selectively remove things such as chemicals and particles from water, said Voice, professor of civil and environmental engineering. They are analogous to filters except they remove things that are smaller and separate on the basis of chemistry and size. Our proj...

Tree Bark Substance may Hold New Lung-cancer Treatment

...ing a drug like beta-lapachone, they are hoping to selectively target cancer tumors and kill them more powerfully. Future therapies based on beta-lapachone and NQO1 interaction have the potential to play a major role in treating devastating drug-resistant cancers such as non-small cell lung cancer, said Dr. Er...

Loss of Antenna Leads to Cancer in Insects

...at small-molecule inhibitors of Aurora A and HDAC6 selectively stabilize cilia, the authors concluded, suggesting a novel mode of action for these clinical agents. Clinical trials of such inhibitors have already begun, so learning more about the mechanisms of their targets is important in understanding how th...

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