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Tag: "regulates" at medical news

Fruit Flies May Pave Way to New Treatments for Age-related Heart Disease

... This membrane channel, found in flies and humans, regulates the heart’s ability to return to a relaxed state after beating. This ability is crucial to healthy cardiac functions, and the inability to return to a relaxed state results in arrhythmias, which can lead to more serious heart disease and sudden death...

Fetal Heart-Cell Enzyme and Onset of Heart Failure

...this fetal-gene reactivation happens, yet not what regulates it. Now, investigators at the University of Pennsy...n enzyme important in fetal heart-cell development regulates the enlargement of heart cells, known as cardiac hypertrophy, which is a precursor to many forms of ...

Researchers Identify Cell Pathway in Colon Cancer

...shows that receptor protein tyrosine phosphatase T regulates an important signaling pathway that is critical in cancer development. This identification will allow new approaches to pharmacological designs and facilitate alternative approaches for cancer treatment”, said Wang. With over 52,000 deaths each ye...

Cholesterol and Insulin Secretion -bound by a Gene

...y as it aids in cell membrane function, meaning it regulates the materials entering and leaving a cell. The presence of cholesterol in the pancreas and its high expression was brought to the lead author’s notice by one of his students, Dr. Liam Brunham .In response to that the researcher Dr. Michael Hayden,...

'Gateway' Gene Discovered for Brain Cancer

... Olig2 is a 'transcription factor'—a protein that regulates the activity of genes. Prior studies had indicated that it plays a central role in enabling neural stem cells to replicate during embryonic brain development. Also, studies have suggested that brain tumors might arise from aberrant neural stem cells ...

Scientists Discover New Gene

...rs. "CHD5 functions like a circuit breaker that regulates the tumor-preventing power in our cells—when it blows, cancer occurs," explains Mills. Modulation of CHD5 activity may provide novel strategies for better design of more effective cancer therapies. This gene has remained a mystery until the discovery...

Pregnant? Check Your Thyroid Secretion!

...o. Thyroxine, the hormone secreted by this gland regulates metabolism and plays a very vital role in the formation of various tissues. An over secretion of thyroid called Hyperthyroidism increases heart rate and blood pressure, causes weight loss, depression and vision problems. Whereas an under active thy...

Rett Syndrome Reversed in Genetic Mouse Model

...y Bird in 1990, is considered to be a protein that regulates the expression of other genes by turning them off at the appropriate time. In 1999 Huda Zoghbi, M.D., Professor, Departments of Molecular and Human Genetics, Pediatrics, Neurology, and Neuroscience at Baylor College of Medicine discovered that RTT ...

Mutation In PALB2 Elevates Risk of Cancer

...dentified a novel BRCA2 binding factor, PALB2 that regulates certain key functions of normal BRCA2 activity. The next step was to set out to evaluate the newly detected PALB2 gene as a potential heritable breast cancer susceptibility candidate by screening for disease-related alterations. The results of this i...

FDA Clears Breast Cancer Specific Molecular Prognostic Test

...oped and used by a single laboratory. Although FDA regulates diagnostic tests sold to laboratories, hospitals and physicians, it uses discretion when regulating tests developed and performed by single laboratories. On February 8, FDA will hold a public meeting to discuss its draft guidance document describin...

NIMH Studies Woman’s Hormonal Cycl

...he amygdala and a cortex area behind the eyes that regulates emotion and reward-related planning behavior more during the pre-ovulation phase (four to eight days after their period began) than in the post-ovulatory phase. When they hit the jackpot and actually won a reward, women in the pre-ovulatory phase a...

A Protein in Brain Cells Controls Obesity: Research

...s, they were able to show that the action of SH2B1 regulates body weight, the action of the metabolic signaling molecules leptin and insulin, and the use of energy from food. It even moderated the impact of a high-fat diet on body weight. The experiments were performed in mice, including two types of mice t...

High-fibre Diets can Bust Breast Cancer

... The researchers attributed this to the way fibre regulates and processes estrogen, which is present in higher amounts in younger women. Says Professor Janet Cade, "Our study found no protective effect in the older group, but significant evidence of a link in the pre-menopausal women. In addition, post-meno...

Scientists Map Key Landmarks in Human Genome

...f other genes. "We wanted to understand how MITF regulates target genes, and specifically where in promoter regions of those genes does MITF bind," Fisher said. "In the process of this work, we asked whether MITF is binding between nucleosomes or on top of nucleosomes, and that led us to devise a method to a...

Missing Molecule Has Important Role in a Developmental Brain Abnormality

...derstood. This study shows that the molecule MEKK4 regulates Filamin-A and its loss contributes to PVH. “We show that MEKK4 deficiency leads to both a breakdown in the lining of the fetal ventricles and abnormally high levels of Filamin-A within the proliferative areas,” Rakic said. Using advanced molecular me...

Estrogen Curbs Appetite In Same Way as the Hormone Leptin

Estrogen regulates the brain’s energy metabolism in the same way as the hormone leptin, leading the way to a viable approach to tackling obesity in people resistant to leptin//, researchers at Yale School of Medicine report in the online issue of Nature Medicine. “We...

Estrogen Curbs Appetite: Research

...le School of Medicine have found out that Estrogen regulates the brain's energy metabolism in the same way as the hormone leptin, leading the way to a viable// approach to tackling obesity in people resistant to leptin. Their findings were published in the December 31 online issue of Nature Medicine. "We fo...

Regrowth of Zebrafish's Tail Fin may Offer Clues for Treating Human Injuries

... communication, called Wnt/Beta-catenin signaling, regulates the fate of these as-yet undeveloped cells as an embryo forms. Through a cascade of signals, cells waiting for their calling learn which spot to take to help form the embryo, what kinds of cells to become there, and how many cells like themselves sho...

Molecular ‘On/Off Switch’ Controls Immune Defenses Against Viruss

...s of each protein. The domain is the key site that regulates the ability of RIG-I to bind to its signaling partners, including LGP2, acting as a switch for controlling immune response, Dr. Gale said. “Hepatitis C and others viruses hijack this signaling pathway to stop immune defenses,” he said. His resear...

High Doses of Lithium-Like Drugs May Impair Neuronal Function

...at tends to allow the processes inside the cell it regulates to function normally," Snider said. But when the researchers strongly inhibited GSK-3 beta in mouse neurons in cell culture, the growth of axons, which carry messages between nerve cells, was markedly reduced. The researchers inhibited GSK-3 beta...

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