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Tag: "protein" at medical news

New Understanding on Growth of Human Stem Cells

...actor 2 (IGF-II), which they now show could be the protein to sustain hESCs. Researchers are interested in the relationship between stem cells and their niche, because the niche represents a route for modifying stem cell behaviour if human ES cells can be reliably guided down a particular pathway, then the...

Protein Interaction is a Drug Target for Blood Clot Prevention

... California San Diego show that the binding of the protein talin to alpha-IIb beta 3 is critical for integrin activation in mice, and that selective disruption of the talinalpha-IIb beta 3 interaction protects mice from pulmonary thromboembolism the formation of blood clots in the vessel that carries blood ...

Tumor Blood Flow can Improve Chemotherapy

...ent by using the drug bevacizumab to block VEGF, a protein that stimulates blood vessel growth in tumors and then following with the chemotherapy drug topotecan, which depends on blood vessels to penetrate the tumor and kill the cancer cells. A report on this work appears in the current issue of Clinical Can...

A New Monoclonal Antibody Kills Cancer Cells

...nd analyzed them for level of expression of an RTK protein known as platelet-derived growth factor receptor-alpha.The investigators also analyzed the cells for their level of activation of the PDGFR gene. At an early fetal stage of liver development in the mouse, the investigators found that the level of e...

Src Inhibitors in Breast Cancer Therapy

...This lack of correlation between ER-alpha mRNA and protein levels pointed to the existence of important post-...nes showed increased levels and/or activity of the protein Src, which cooperates with estrogen to activate ER-alpha breakdown via proteolysis. In line with t...

Eap1 in the Brain Regulates the Female Reproductive Cycle

...monkeys, rats, and mice. They also showed that the protein product of EPA1 was expressed in neurons involved in the control of reproduction, and that EAP1 activated GnRH. The authors went on to show that inhibition of EPA1 expression in the rat hypothalamus delayed the onset of puberty and disrupted estrou...

Autoimmune Response in Multiple Sclerosis

...pulses and, ultimately, axon loss . Myelin basic protein (MBP) is a major component of the myelin sheath and when used as an antigen will induce experimental autoimmune encephalitis (EAE) in mice, which is used as an animal model of human MS. Interestingly, myelin-specific T cells are found in both healt...

Understanding HIV Interference With Infected Cell Division

...e center of this process is the HIV protein, viral protein R (Vpr), which stops infected CD4+T cells from div...ohen and his team have identified a novel cellular protein complex targeted by HIV-1 Vpr to stop infected cell division. This protein complex, designated DDB1-...

Bak Protein Sets Stressed Cells on Suicide Path

...ressed, say by a heart attack, stroke or cancer, a protein called Bak just may set it up for suicide, resear...hondrion, into vulnerable little spheres. Another protein Bax then pokes countless holes in those spheres, spilling their pro-death contents into the cell. ...

The Importance of Junk DNA

...ns, only about 4 percent of the genome encodes for protein function; the remainder, or junk DNA, represents repetitive and non-coding sequences. The research team studied a repeated genomic sequence called SINE B2, which is located on the growth hormone gene locus, the gene related to the aging process and l...

Genetic Variation in Some Smokers Increases Chances of Developing COPD

...ene is responsible for the production of the IL-13 protein that is involved in pulmonary inflammation and sus...standing more about the role of IL-13 in COPD, the protein may eventually be a target for new drugs for the disease. The variant has been shown to be associa...

Circassia Announces Acquisition of Organ Transplant Anti-Rejection Technology

...n the recipient's immune system reacts strongly to protein molecules, termed antigens, present on the cells of the donated organ. The ToleroTrans technology employs specific small portions of antigen molecules, called T-cell epitopes. Scientists then test these epitopes, utilising blood samples from patients...

Courtney Love Cracks a Joke on Her anorexic Appearance

...singer stopped between songs and took a sip from a protein shake, then apologized to the crowd, saying that she "had to take care of my eating disorder." "I requested Ensure shakes for my anorexia. You're going to have to wait for my eating disorder. Its getting kinda spooky but the free clothes are great, ...

Protein Structure of Pathogens Associated With CF and TB Solved

The structure of a novel protein in the bacterium that is the most persistent patho...he first structural characterization of this novel protein that is present in many bacteria including the pathogen that causes tuberculosis.It's well-known tha...

New Target for Muscular Dystrophy Drug Therapy Discovered

... found how the gene for utrophin-which codes for a protein very similar to dystrophin, the defective protein in Duchenne muscular dystrophy (DMD)-puts the brakes on its own expression in muscle cells. The p...

Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers

...d cancers . Ras is a key intracellular messenger protein that directs, among other things, cell growth and proliferation. Over-expression of the Ras oncogene, or of its growth-promoting pathway, is an integral step in the development of a number of human cancers, particularly pancreatic and lung cancer. ...

Key Mechanism to Emergence of Strep Bacteria

...small subpopulation of the strep bacteria hijack a protein called plasminogen from the human bloodstream. The bacteria attach the protein to their own surface, and then activate it into a protease an enzyme that digests proteins and is c...

First Drug for Post-traumatic Stress Disorder

...nter for storing memories. Cdk5, paired with the protein p35, helps new brain cells, or neurons, form and m...ng components of a molecular pathway involving the protein kinase Cdk5," said Tsai, a Howard Hughes Medical Institute investigator. "We found that Cdk5 acti...

Researchers Find New Target for Anti-cancer Drugs

...w target for anti-cancer drugs, by focusing on the protein activated by the gene instead of concentrating on well-known gene implicated in almost one-third of all cancers. In experiments with human cells and animal models, the researchers studied the gene known as Ras, which is integral in normal cell gro...

Human Membranes Crystal Structure may Help Tailor Asthma Drugs

...ion information has been available on two membrane protein structures from human. Now, researchers at Karo...olution. It is clear from the structure that the protein has three identical subunits, each of them consisting of four spiral structures that cover the nucle...

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