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Tag: "proteasome" at medical news

Successful Islet Cell Transplant in Mice With Type 1 Diabetes

...atients to see if they are suitable candidates for proteasome inhibitors, a promising class of anti-cancer drugs...n cancer patients whose tumors do not produce p53, proteasome inhibitors might be ineffective. This patient group could be spared unnecessary treatment with possi...

Philadelphia Researchers Found A Novel Way To Fight Several Kind of Cancers

... both surprised and lucky," he says. "Velcade is a proteasome inhibitor, but it also induces the lytic cycle thereby activating the TK in the Epstein-Barr virus. Once the TK is activated, we can image the tumors." To test their findings, the researchers used mice carrying human Burkitt's lymphoma, a cancer o...

Tailor-made Cancer Treatment for Multiple Myeloma Patients Offered by Mayo Clinic

...e first approved in a new class of agents known as proteasome inhibitors. Proteasomes are large protein groups i...break down other proteins. Agents that inhibit the proteasome cause a buildup of proteins that affect many signaling cascades (various necessary biological proces...

'Mix and match' of proteins may have a significant role in immunity

...ieces, leads to the formation of peptides. "The proteasome can splice peptides together," says Warren. “Every once in a while, new peptide bonds will be created, not just destroyed. It isn't clear why this happens, or what the newly spliced peptides do. But as the molecules end up on the cell's surface, they...

Cellular System Causing Destruction Of Faulty Proteins In Cystic Fibrosis Identified

...asome. This trash system is known as the ubiquitin proteasome pathway. "We've identified the trash collectors that recognize misfolded proteins, decide if they might be toxic to the cell and mark them with ubiquitin. The ubiquitinated proteins, including faulty CFTR, are then degraded or shredded by the prot...

Study Would Pave Way for the Development of New Drugs That Targets TB Proteasome

...the structure and biochemistry of the TB bacterial proteasome from those found in human cells. This would greatl... human cell survival. So any drug targeting the TB proteasome would have to be extremely specific. Hence studies should be very specific in identifying the unique...

Latest drug shows promise in multiple myeloma

...r later. Bortezomib is a new kind of drug called a proteasome inhibitor. It acts on tiny structures called proteasomes within cells and so stops myeloma cells from multiplying....

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