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Tag: "promoter" at medical news

Reducing Number Of Cigarettes Not Enough

...ight that tobacco’s role as a cancer initiator and promoter is not only complex, but also remains one of the greatest global public health challenges. Given the strong evidence, NCI researchers say the most dramatic health benefits in the next half-century will happen when the number of smokers who quit signi...

Gene linked to colorectal cancer identified

...The researchers found that methylation in the MGMT promoter region was found in 50% to 94% of colorectal cance...T is often methylated, which means that the gene's promoter region has methyl chemical groups added to it, resulting in an unhealthy inactivation of the gene. ...

Synthetic protein found to relieve arthritis symptoms in animal model

...the symptoms of TNF-alpha-induced arthritis (a key promoter of inflammation is a chemical called tumor necrosis factor alpha- TNF-alpha). Moreover, it also appeared to inhibit disease symptoms in mice with established as well as acute arthritis. The scientists did not detect any obvious toxicity in the PLAD-t...

Malaria’s Invisibility Code Identifie

...hinery, according to the HHMI research. The gene's promoter which is a DNA sequence initiates the production o... nucleus, wherein the chromosome ends surround the promoter which contain the silenced var genes. The art of cloning big DNA sequences had to be mastered by the...

Anemia from Malaria Linked to a Protein MIF

...s in response to infection. One version of the MIF promoter leads to less MIF protein made, while cells containing another version of the MIF promoter make much more MIF protein. Differences in the MIF promoter also have been linked to the severity of...

Call Center Workers At An Increased Risk Of Breast Cancer

...aries to kick out extra estrogen, a known hormonal promoter of breast cancer," he said. Colina added that the study had showed that the risk of developing the cancer increased by as much as 60 percent. Nighttime work may also play havoc with the menstrual cycle. "Painful menstruation (dysmenorrhea), absence...

The Dengue Virus Unplugged

...ecognize that it serves a role in bringing the SLA promoter near the initiation site.' Paul Ahlquist, an HHMI investigator at the University of Wisconsin-Madison and an expert on RNA viruses, said that the Gamarnik team's findings explain prior observations from her lab and others that binding between the 5...

Apollo's Global Arm Acquires US-based Firm

...conference here in the presence of William Colgan, promoter and managing director, AFS. The acquisition deal, through internal accruals, equity and debt will be completed in three years and AFS will remain a 100 percent subsidiary of AHS in United States. "With this acquisition, the combined Apollo-AFS en...

Raloxifene Reduces The Risk Of Breast Cancer

... concentration of estrogen, which acts as a tumour promoter in the majority of breast cancers,' said Dr. Lippman. The research team conducted a new analysis of the first large study of raloxifene, which tested the ability of the drug to prevent vertebral fractures in 7,705 postmenopausal women diagnosed wit...

India's First Stem Cell Transplant Center Launched in Chennai

... investing Rs.500-600 million in expansion through promoter funding but we are also open to private equity funding," Mangipudi added. "We plan to open collection centers soon in Dubai, Kuala Lumpur, Singapore. Our Dubai center will also have its own collection bank and the Malaysian center is going to be o...

A Novel Technique That Detects "Cancer Genes" From The Breath Of Smokers

...ene is chemically silenced. The assay examines the promoter region of a gene, where certain cytosine nucleotide bases may be methylated, preventing the gene from being expressed. The seven participants tested so far breathe for ten minutes into a commercially available handheld device, which cools the air, ...

Scientists Map Key Landmarks in Human Genome

... regulates target genes, and specifically where in promoter regions of those genes does MITF bind," Fisher said. "In the process of this work, we asked whether MITF is binding between nucleosomes or on top of nucleosomes, and that led us to devise a method to ask where the nucleosomes are located." The rese...

Probing the Effect of Endurance Exercise on Athletes' Hearts

... for our findings is that exercise also acted as a promoter of the RV changes, maybe in synergy with other environmental or genetic factors, and hence led to arrhythmias. Our study does not provide definitive proof for either of these explanations, but our data contribute to the accumulating, indirect evidenc...

Scientists Identify Gene That May Indicate Predisposition To Schizophrenia

...etween schizophrenia and genetic variations in the promoter region of the chitinase 3-like 1 (CHI3L1) gene, an association that was significant in both population-based and family-based investigations. The CHI3L1 gene acts as a survival factor in response to adverse environments, countering various types o...

Hostile Behavior in Women may Be Gene Based

...hose who had one or both of two alterations in the promoter region of the serotonin receptor 2C gene were more likely to score lower on two common tests for anger, hostility and aggression. These findings may aid in establishing a potential marker for certain conditions associated with aggression and anger....

Inflammation May Play Role in Metastasis of Prostate Cancer

...lso support the view that RANK ligand is a general promoter of prostate, and possibly breast, cancer metastasis. 'Maspin is a very potent inhibitor of metastasis; in a patient with metastasis, cells have found a way to turn off Maspin, which may depend on invasion of the tumor with RANK ligand-producing ce...

Inflammation Promotes Metastasis of Prostate Cancer

...lso support the view that RANK ligand is a general promoter of prostate, and possibly breast, cancer metastasis. "Maspin is a very potent inhibitor of metastasis; in a patient with metastasis, cells have found a way to turn off Maspin, which may depend on invasion of the tumor with RANK ligand-producing cells...

Fat Screen Delivers Plant-derived Chemical With Antidiabetic Effects

...estore insulin sensitivity by activating a central promoter of fat tissue production called peroxisome proliferator-activated receptor (PPAR). "The current explanation for this paradoxical mode of action is the idea that the body needs a place to store lipids," Tontonoz said. "If the body becomes less able...

Scientists Use Gene Therapy to Reverse Heart Failure in Animals

... humans, Dr. Koch says. "The use of the novel gene promoter to ensure the therapeutic gene is only expressed in heart cells increases the safety of the gene therapy for human use." Congestive heart failure affects nearly five million Americans, many of whom have poor long-term prognoses, despite recent ther...

Researchers Have Identified Cancer Promoter Genes

...er promoters when exposed to a process called DNA promoter hypermethylation. Hypermethylation is a process ...lear grade," said Tao. "Our data suggested that promoter hypermethylation is common in breast cancer," Tao added. "Because promoter hypermethylation is poten...

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