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Tag: "proliferative" at medical news

Insights into Acute Promyelocytic Leukemia

...developing white blood cells get stuck at a highly proliferative and immature stage. The abnormal cells accumulate and eventually crowd out the normal, healthy blood cells. Most cases of APL are caused by the expression of the PML/RARA (promyelocytic leukemia/retinoic acid receptor alpha) oncogene. This oncogene...

Mayo Clinic Study Finds Heart Transplant Patients Benefit from New Approach to Immunosuppression

...ients also greatly impaired the development of the proliferative changes found in transplant coronary artery disease. "Based on our findings, patients should still receive calcineurin inhibitors as the primary immunosuppressant immediately after transplant, and the conversion to sirolimus must be gradual in orde...

Missing Molecule Has Important Role in a Developmental Brain Abnormality

...and abnormally high levels of Filamin-A within the proliferative areas,” Rakic said. Using advanced molecular methods, the researchers showed that the loss of MEKK4 can result in an excess of Filamin-A, and inhibit neuronal migration.The grey matter of human cerebral cortex contains over two billion neurons, but n...

Limb Regeneration Exists Innately In All Vertebrates – Says Researc

...d in fruit flies) are known to play a role in cell proliferative processes, like fetal growth and cancer development, and Belmonte's lab has characterized the crucial role of Wnt signaling in limb growth. In 1995, the Salk researchers were first to demonstrate that they could induce the growth of extra limbs in em...

'Muscle' Protein Drives Prostate Cancer

...rade prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy. Finally, when they altered some cancerous cells by knocking down their myosin VI protein, the cancer cells not only were less able to spread around, but also showed 10 times the amount of a tumor suppressor called thioredoxin...

Anti Atherosclerosis Therapies Linked to Leukemia

...ls. The majority of mice were seen to have myeloid proliferative disease, a precursor to CML. And 15 percent of the...CML yet found. The subset of the mice with myeloid proliferative disease closely mimic the asymptomatic early stages of CML, while the 15 percent with clear CML mode...

Exercise Has An Anti-Cancer Effect

...sulin-like growth factor-1 (IGF-1), blocks IGF-1’s proliferative effect on cell growth, due to which the result appears. In the Melbourne Collaborative Cohort Study, Dr. Andrew M. M. Haydon and colleagues at Manash Medical School in Melbourne found out new cases of colorectal cancer in studying 41,528 adults dur...

Mouse Models To Determine The Cause Of Aggressive Leukemia

...sing the Bcr-Abl enzyme gives these cells a strong proliferative nature which might contribute to imatinib resistance. So the researchers used a virus-like piece of DNA to carry the Bcr-Abl oncogene into bone marrow-derived lymphocytes obtained from mice that either retained Arf or were previously engineered to la...

Protective regimen for acute Graft-versus-host disease

...stimulation increased by a factor of five, and the proliferative response to alloantigens in vitro was reduced, as compared with normal control subjects and control subjects who underwent conditioning with a single dose of total-body irradiation (200 cGy). The study concludes that a regimen of nonmyelo...

knowledge of proliferative sickle cell retinopathy can help Prevent eye trauma

... the incidence, prevalence, and natural history of proliferative sickle cell retinopathy (PSR) in a patient populat... dependent on the early detection and treatment of proliferative sickle cell retinopathy....

Third generation Small pox vaccine from Cell-culture

...ermined by neutralization, Antibody titers, T-cell proliferative response assays and interferon-? elispot. Only one vaccinated person developed pock lesions. The number of participants who became immune to the virus was high, with increased measures of cell mediated immunity in CCSV recipients. These results show ...

Understanding Chronic Infections May Help in Developing Therapeutic Vaccines

... load or enhance T cell function, particularly the proliferative capacity of T cells. Possible examples include anti-virals that could be given prior to therapeutic vaccination, or a cytokine that might boost the proliferation or survival of responding cells. While Wherry's primary interest is in chronic infection...

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