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Tag: "preclinical" at medical news

Maxygen Initiates Phase IIa Clinical Trial of MAXY-G34 in Breast Cancer Patients

...cyte colony stimulating factor (PEG-GCSF) shown in preclinical and Phase I studies to have novel and potentially superior properties compared to the current PEG- GCSF therapy. "Patients and physicians have limited options for treatment of neutropenia," said Russell Howard, chief executive officer of Maxygen. "...

Stem Cells Research in Parkinsons Disease

...osing and brain sites to target. Pending further preclinical studies, he writes in the commentary, the results so far from the current study are supportive for developing a safe and effective stem cell treatment for Parkinsons disease. Dr. Sanbergs commentary and the study it highlights will also be publishe...

Milk Thistle Extract Effective in Cancer Treatment

...ancer patients. "This special issue presents both preclinical and clinical studies demonstrating the potential role of milk thistle as an anticancer agent. No other medications or supplements are currently available that preserve liver function and provide clinical benefits," write the guest editors in their op...

Lobster Shells Have Great Healing and Antiseptic Properties

... both healing and antimicrobial properties. After preclinical and clinical trials were approved, both surgical thread types were introduced and successfully used in several Cuban hospitals. The study, however, was not limited to biomedicine and proved useful for agriculture as well. In cooperation with the Cu...

Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers

...re able to successfully fight tumor formation in a preclinical model by suppressing IL6 activity. While further research is needed to determine the effectiveness of IL6 targeted cancer therapies, these initial results are encouraging. "Targeting secreted proteins that Ras activates has opened the door to inhib...

Breast Cancer Risk is not Reduced by a Diet Rich in Fruit and Vegetables

...(the '5-A-Day' diet). 'Considerable evidence from preclinical studies indicates that plant-derived foods contain anticarcinogens.A comprehensive review of the literature found that a diet high in vegetables and fruit probably decreases breast cancer risk and that a diet high in total fat possibly increases risk...

Phase II Data Show Efficacy and Tolerability of Tapentadol in Chronic Pain Treatment

...road analgesic efficacy of tapentadol derived from preclinical models has previously been confirmed for acute pain conditions in a number of clinical studies(2). In line with the acute pain data the current findings confirm tapentadol's improved tolerability compared to other strong centrally acting analgesic...

Alteon Initiates Phase 2 Trial of ALT-2074 in Diabetes and Haptoglobin 2-2

...he potential that ALT-2074 has demonstrated in our preclinical models and we are aggressively pursuing clinical development in this indication.' Diabetes and Metabolic Syndrome, diseases linked to obesity and increased oxidative stress, are growing in epidemic proportions in the United States and many other dev...

Avicena to Advance Huntington's Disease Clinical Program into Phase III

...ence supporting its potential to slow HD. Earlier preclinical studies performed by Dr. Flint Beal of Cornell Medical Center and Dr. Robert Ferante of Boston University, HD-02 have shown significant neuroprotective effects such as improved motor movement and increased survival rate. Avicena intends to collabora...

Surface Logix Commences Phase 2a Clinical Trial of SLx-2101 in Raynaud's Disease

...ics and pharmacodynamic activity. Additionally, in preclinical animal models, the candidate was highly potent and selective, induced rapid cellular and tissue response and provided an extended duration of action....

Risk of Dementia Increased With Secondhand Smoke

...carotid arterial walls, and serve as indicators of preclinical cardiovascular disease and are risk factors for stroke. People with these underlying conditions and high lifetime exposure to secondhand smoke were nearly two-and-a-half times as likely to develop dementia as those with no secondhand smoke exposure a...

Novel Delivery Method of Insulin Gene to Combat Juvenile Diabetes Developed

...than more commonly used virus-based agents. In the preclinical testing reported in this conference, a single administration of the nanoparticles induced the production of insulin in the recipients for over 130 days. Moreover, the insulin production was responsive to meals. Work is currently underway to support...

Cell Genesys Reports Additional Data From Phase 2 Clinical Trial of GVAX Immunotherapy for Pancreatic Cancer

...rogress, results and timing of clinical trials and preclinical programs and the nature of product pipelines are forward-looking statements and are subject to a number of uncertainties that could cause actual results to differ materially from the statements made, including risks associated with the success of cli...

Risk of Dementia Increased With Secondhand Smoke

...carotid arterial walls, and serve as indicators of preclinical cardiovascular disease and are risk factors for stroke. People with these underlying conditions and high lifetime exposure to secondhand smoke were nearly two-and-a-half times as likely to develop dementia as those with no secondhand smoke exposure a...

Correlation Between Bile Duct Obstruction and Ductal Cancer Found

...r drug therapy. Second, they establish a unique preclinical model of how bile duct cancer in liver progresses that can be used to rapidly test and evaluate novel molecular treatment strategies. Such strategies are badly needed for this understudied cancer, adds Dr. Sirica. The incidence and mortality of cho...

Deficiency in Vitamin D Increases the Risk of Cancer

... primarily focused on the use of calcitriol. While preclinical data and limited clinical data strongly suggest that calcitriol and other vitamin D analogues have a role in the suppression of established cancer, questions remain about optimal dose, schedule and formulation of calcitriol compound. Further investig...

Anticancer Effects of Curcumin Revealed

...e the molecular anticancer effect of curcumin in a preclinical prostate cancer model. Using PC-3 human prostate cancer cell lines grown in vitro, curcumin was found to decrease the mRNA and protein expression of the oncoprotein MDM2 and to enhance the expression of tumor modulator p21. This translated into an ...

MRI Robotic Biopsies Simplified by PneuStep

... prostate gland. The robot currently is undergoing preclinical testing. "Prostate cancer is tricky because it only can be seen under MRI, and in early stages it can be quite small and easy to miss," says Stoianovici. The new Johns Hopkins motor, dubbed PneuStep, consists of three pistons connected to a serie...

MRI-safe Motor Makes Robotic Biopsies Possible

... prostate gland. The robot currently is undergoing preclinical testing. "Prostate cancer is tricky because it only can be seen under MRI, and in early stages it can be quite small and easy to miss," says Stoianovici. The new Johns Hopkins motor, dubbed PneuStep, consists of three pistons connected to a ser...

Rice Bran Reduces Risk of Intestinal Cancer

... The results of a controlled laboratory study in a preclinical model of gastrointestinal adenoma demonstrated that consumption of a high daily dose of stabilized rice bran caused an average 51% reduction in the number of precancerous adenomas in the intestinal tract. Professor Andreas Gescher of the Universit...

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