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Tag: "peptides" at medical news

New Technique Dissects Stem Cells' Picky Likes, Dislikes

...rfaces of specially treated microscope slides. The peptides were arranged in a regular pattern of squares, eac...ent conditions within a single square inch. The peptides her team chose to test first come from a major protein component of the ECM called laminin. Laminin ...

Researchers Identifies Molecules That is Effective in Fighting Against Breast Cancer

... researchers had shown that 8-mer and cyclic 9-mer peptides inhibit breast cancer in mouse and rat models, interacting with an unsolved receptor, while peptides smaller than eight amino acids did not. The Hamilton researchers used advanced computational meth...

US Professors Develop Fusion Protein to Fight Cancer

...he product of joining two genes or two proteins or peptides together. Fusion proteins can happen naturally or it can be created artificially in a laboratory for research purposes. The newly developed protein by Thomas Pento and Roger Harrison can keep some types of cancer cells from ingesting a vital protei...

Appetite-regulating Peptides Influence Alcohol Cravings

A new study has confirmed that appetite-regulating peptides leptin and ghrelin influence alcohol cravings for ...e chose to examine leptin and ghrelin because both peptides are of high importance in appetite regulation and both have already been subject to former investiga...

Specific Imbalance Between Two Peptides may Cause Alzheimer's

..., suggesting that a specific imbalance between two peptides may be responsible for preventing this form of dem... in Taiji, an ancient Chinese philosophy. When the peptides are produced in the correct proportions, the brain is healthy; but when that delicate balance is cha...

Super Fruit Fly may Harbor Hope for Human Longevity

...Roberts and his group literally threw trillions of peptides at the receptor and saved the ones that stuck. W...er multiple cycles, the researchers had a group of peptides that fixed to the receptor and not to any other protein. Fruit flies genetically transformed to pr...

Head and Neck Cancer Vaccine Targets Proteins to Create Immune Response

...egy for head and neck cancer that targets multiple peptides (parts of proteins) to activate the immune system/... p53 also expresses unaltered, or "wild-type," p53 peptides in tumors. When presented on dendritic cells, these wild-type p53 peptides may induce an immune resp...

Breast Cancer Vaccine Stimulates Potent Immune Response to Cancer Cells

...s long as 39 weeks. Because the use of synthetic peptides alone generally does not trigger a strong immune r...ain the immune system to recognize these synthetic peptides as dangerous foreign agents of the HER-2/neu gene by mimicking what the bacteria would do in your bo...

Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane

...y of Pennsylvania School of Medicine have designed peptides that are able to bind to specific regions of trans...cience, looks at how the binding of these designed peptides affects the crucial first steps in blood clotting. "We can now actually interrogate parts of prote...

Scientists Explore Ways to Reduce Insulin Resistance by ‘handcuffing’ Gens

... This was discovered after ucocortin 2. Both are peptides produced in the insulin secreting cells of the pancreas and both are responsible for the increased production of insulin, when a diet high in sugar and fat is taken. The scientists led by Wylie Vale, discovered that when mice bred without the gene...

Natural Antibiotics Yield Secrets to Atom-level Imaging Technique

...erties of natural antibiotics called antimicrobial peptides (AMPs), which are produced by virtually all animal...years, they're still puzzling over exactly how the peptides wipe out bacteria and other microbes. Unlike conventional antibiotics, which typically inhibit speci...

Common Ingredient in Big Macs and Sodas Can Stabilize Gold Nanoparticles for Medical Use

...aid. The new generation of trimeric amino acids peptides discovered by Katti in 1999 (referred to by Amijii as 'Katti Peptides') have provided a solid chemical platform and have become sources of a number of other discoveries. Their applications in the development of drugs for Wilscons' disease; their util...

Bacteria Fighter Goes Where Antibiotics Can't

...t bacteria. Unlike most antibiotics, antimicrobial peptides can sidestep such resistance mechanisms and destro...n a targeted cell. For this reason, “antimicrobial peptides present an obvious advantage over conventional antibiotics,” said Mor. Yet one of the features tha...

Man-Made Proteins Could Be More Useful Than Real Ones

...hepartz said. For example, when helices of natural peptides nestle against one another, often their “side chains” extend from the sides of each helix, fitting together like ridges in grooves. The a-peptide helices, however, are structured so that their side chains alternate like interlocking fingers. Schep...

New Test Predicts CLL’s Sensitivity to Experimental Drug

...lls; then they exposed them to protein fragments – peptides – that were known to interact with survival molecules like Bcl-2. "If they interact, then the cell is primed to die, and the test will identify which of the survival molecules is keeping the cells alive," he added. "Then you know that to kill the cel...

Buckyballs Used as 'Passkey' into Cancer Cells

... with pheylalanine as a link in their chain, these peptides did not pass through the cell walls. Barron's gr...dren's Cancer Center, and found the Baa-containing peptides could mimick viral proteins and pass through the walls of cancer cells. The peptides were found effe...

Scientists Come Up With A Powerful Weapon To Fight Drug Resistant Bacteria

...uced by all organisms. Because these antimicrobial peptides (AMPs) are positively charged, they are attracted ...enough, they managed to design these new synthetic peptides (protein fragments) to contain only four amino acids, as opposed to the 12 - 50 found in their natur...

MIT Creates 3-D Scaffold for Growing Stem Cells

...ny fragments of amino acids called self-assembling peptides to organize themselves into useful structures. Working with visiting graduate student Fabrizio Gelain from Milan, Zhang created a designer scaffold from a network of protein nanofibers, each 5,000 times thinner than a human hair and containing pores ...

Genes determine the capacity to fight HIV in early stages

...wn to bind to those HLA types to see if particular peptides were more powerful in activating the HIV-specific CD8 response. The researchers found that, for many varieties of HLA, only a few HIV protein fragments were responsible for the activation of CD8 T cells early in infection. In addition, the same HLA ...

New Drug Blocks Influenza, Including Bird Flu Virus

...alities of the peptide were observed after similar peptides were found by Brandt and his colleagues to stop herpes simplex virus infection. The Wisconsin work was supported by grants from the UW-Madison School of Medicine and Public Health Education and Research Committee, the National Institutes of Health ...

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