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Tag: "pathways" at medical news

FDA Nanotechnology Task Force takes positive step forward

...clear guidance so there can be reasonable and safe pathways to market for the many potential applications of nanotechnology under FDA’s jurisdiction. Equally important, the report signals FDA’s commitment to a transparent public process for developing its regulatory policies. Public participation will be key...

A new century of Alzheimer's disease research

...mal functioning of the nerve cells, destroying the pathways along which packets of chemical “information” move. Memories cannot be stored or retrieved, and, eventually, the brain cannot control the body. Each year about 4.6 million more people develop Alzheimer’s worldwide, and that number is escalating rapid...

Structure of TB Enzyme Points the Way to New Drugs: Study

...ers said that the new drugs by targeting different pathways than those used by existing antibiotics should side-step various problems with these drugs, specifically their inability to destroy the bacteria in its dormant form, which is one of the reasons that resistance has emerged. The study appears in the ...

Strange Sex Life of Mole-rats may Provide Clues About Human Infertility

...ctively active. Social stress acts through brain pathways that control reproductive hormones which are likely to be similar in both animals and humans, said Dr Faulkes. Social suppression of reproduction in marmoset monkeys is very similar to that in naked mole-rats, and as these are primates the applicat...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

...hway is among the most commonly activated cellular pathways in human cancers and members of this pathway are among the most frequently targeted for new cancer drug discovery efforts. The activation of this pathway results in cancer cell growth and cell survival, according to the background information in a...

Insight Into Neural Stem Cells Has Implications For Designing Therapies

...n us 10 years," he says, "to figure out that these pathways reflect the transport of young neurons of different types born in unique locations."...

Scientists Find Single Circuit Channeling Depression in Rats

...grail of psychiatry is to try to find final common pathways that can make sense of how genes and life experiences end up with the same result," he said. "And the same goes for medications. There are many treatments that act in fundamentally different ways -- how do we make sense of all that complexity?"...

Brain Pathway for Depression Revealed

...grail of psychiatry is to try to find final common pathways that can make sense of how genes and life experiences end up with the same result," said Deisseroth. "And the same goes for medications. There are many treatments that act in fundamentally different ways - how do we make sense of all that complexity"...

FDA Approve S Robotic Device to Help Stroke Patients

...the arm, rebuilding and strengthening neurological pathways in the process. The device is designed to help get patients over a functional hump so they can start moving the weakened arm again, said John McBean, a mechanical engineer who developed the technology with Kailas Narendran, an electrical engineer a...

Insights into Acute Promyelocytic Leukemia

...ential. Importantly, disruption of RXR-dependent pathways suppressed RARA fusion-mediated transformation. The authors also suggest that disruption of homotetramers into homodimers may be sufficient to abrogate the transformation ability of RARA fusion proteins. "These findings not only identify the key e...

New Cancer Therapy in Clinical Trial

...r understanding of TRAIL-associated cell signaling pathways in cancer cells and to look for ways to pharmacologically optimize TRAIL therapy. Dr. El-Deirys group had previously established that c-Myc is a key mediator of TRAIL-induced apoptosis and that cancer cells lacking c-Myc and a functional apoptotic ...

Understanding the Mechanism Underlying Embryo Development

...s along a pathway of signalling molecules. These pathways have been conserved across evolution, and therefor...ntral nervous system, and the genes and signalling pathways involved are conserved in both Drosophila and vertebrate species. Although biologists already had a...

Alternative Option for Type2 Diabetes Treatment

...n as incretin-based therapy, which act via certain pathways that affect glucose metabolism may provide modest effectiveness and favorable weight change outcomes for the treatment of type 2 diabetes and may represent an alternative to other hypoglycemic therapies. Current therapies for type 2 diabetes are o...

A New Monoclonal Antibody Kills Cancer Cells

...osis. Based on previous studies showing that some pathways that were previously thought to be active only during fetal liver development, particularly the class III receptor tyrosine kinase (RTK) family pathway, became highly active again in the liver of HCC patients, Satdarshan P. Singh Monga, M.D., associa...

Plants Respond to Changing Environment

... favourable. This involves many complex signalling pathways which are integrated by the plant growth hormone gibberellin. Publishing in the journal Current Biology, the researchers looked at how plants evolved this ability by looking at the genes involved in the gibberellin signalling pathway in a wide rang...

Boffins Find Evidence for Novel Brain Cell Communication

...of as short circuits linking or cutting across the pathways through which cells normally communicate. Gap junctions are found in many parts of the body, such as the heart and have been most studied in older vertebrates (such as fish) and in invertebrates (such as leeches and crabs). The current study pro...

Alien Hand Syndrome Causes Random Hand Movement

...ts in the left visual field even though the visual pathways are intact) as a result of the stroke. The researchers performed two functional MRI experiments in which the patient performed simple motor tasks that allowed them to compare similar left-hand movements executed both consciously and unconsciously. ...

Rare Womens Lung Disease May Yield Insights Into Common Diseases

...t research on common diseases because the cellular pathways that are activated in tuberous sclerosis and LAM are also activated in many forms of cancer, and in diabetes and obesity. What is learned about LAM may help us understand more common diseases in which hormones play an important role, such as breast c...

Buckyball Has the Ability to Fight Against Allergy: Research

...s harm, so we are always interested in finding new pathways to help manage the harmful effects," said Kepley. The new study findings were published online in the Journal of Immunology....

Researchers Have Found the Role of Protein in Accelerating Breast Cancer Progression

...cient to stimulate many of the critical signalling pathways that aggressively promote breast cancer progression." Using genetically modified mouse models, the study found that the inappropriate expression of PTN produced breast cancers of a more aggressive subtype. In those same mouse models, highly malignan...

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