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Tag: "pathway" at medical news

Enzyme may be target for obesity drugs

...t of obese people, it is very likely that the same pathway is involved in many cases of human obesity. Blocking the enzyme may be an important new tool for treating obesity and its complications....

Focused Treatment For Childhood Cancer

...n those tumors that have that particular molecular pathway active," says Pomeroy. Recently developed compounds that can block the uncontrolled SHH signaling found in the tumors could potentially be used as a therapy in children with medulloblastoma. Researchers also found that the clinical outcome of an in...

Chemical in Gila monster's saliva yields Alzheimer drug

...emical which acts on a previously unknown receptor pathway in the brain that affects memory. New York-based biotechnology company Axonyx Inc., which is developing the drug, Gilatide, plans to start human trials with it as a treatment for Alzheimer’s disease later this year. A growing number of compan...

New breast cancer genes discovered

... and BRCA2. In other words, they have discovered a pathway on which just one mistake can prevent normal DNA repair processes. This discovery could lead to new tests for breast cancer susceptibility and even advances in treatments, which could target the damaged genes....

Protein in diabetic neuropathy treatment

... diabetic neuropathy. Researchers say the hedgehog pathway may play a role in the maturing of the nervous system. They found treating diabetic rats with sonic hedgehog protein fully restored their motor and sensory nerves. A researcher from the University of Michigan, in an accompanying commentary said that...

Enzyme help destroy cancer cell

...lls, this research shows another radiation-induced pathway initiated when radiation strikes endothelial cells....

Childhood Sunburn Can Lead to Skin Cancer Later

...it may all come down to the recently discovered Rb pathway -- a series of biochemical signals that can sense when damage occurs in a skin cell and immediately shut down its ability to duplicate itself. Indeed, the American Academy of Dermatology confirms that nearly two-thirds of all melanoma skin cancers a...

New Weapon Against Germs

...und that Trif is the topmost protein shared by the pathway that detects gram-negative bacteria and the pathway that detects most viruses.// This is the first time scientists have identified a protein that direc...

Defending against Tuberculosis

...e. The researchers say they have identified a new pathway (LRG-47) triggered by a host protein called interferon-gamma that disarms TB. Thus far, all of the research has been done in animals, but the researchers believe they have found a human equivalent of this pathway. They say LRG-47 is the correct pathw...

Drug to Prevent the Onset of Arthritis

...of arthritis. The research pinpoints the molecular pathway and an enzyme that play a pivotal role in the onse...ducted research to better understand the molecular pathway involved in the onset of arthritis. Early research has shown activity levels of two enzymes, MMP-2...

Brain Enzyme Found To Regulate Weight

...n appetite signaling at the end of the biochemical pathway in the brain. However researchers say clinical trials on human patients will take years to complete....

How Good Are Vitamins For You ?

...vented the activation of the lipoprotein-breakdown pathway in rat and mouse liver cells. Thus, the liver destroyed fewer of the bad lipoproteins. Though direct tests on people to explore liver function are difficult, observational studies show a diet rich in polyunsaturated fats increases blood levels of li...

Regeneration of muscle

...is only triggered into the muscle cell development pathway by injury. In previous studies, researchers have demonstrated that Pax7 is required to turn adult stem cells into muscle cells during regeneration. Here, the researchers worked with mouse models and in vitro experiments to investigate whether Pax7 i...

Controlling Allergies Before They Start

...Researchers say the new drug works by blocking the pathway within the mast cell, so the histamine is never released. However ,currently, the drug does not have a name and is referred to as R112 and specialists say the effects of the drug will be similar to nasal steroids, but rather than the normal three to...

The Drug Tetrathiomolybdate Found To Be Useful For Various Diseases

...too much fibrosis, and it occurred to us that that pathway might be inhibited by lowering copper. Researchers say they are now working on some of the diseases that may be benefited by lowering copper levels that are of an inflammatory nature such as psoriasis and a disease of the intestinal tract called Cr...

Drug to Delay the Onset of Arthritis

...of arthritis. The research pinpoints the molecular pathway and an enzyme that play a pivotal role in the onse...ducted research to better understand the molecular pathway involved in the onset of arthritis. Early research has shown activity levels of two enzymes, MMP-2 ...

Green Tea Might Help Patients With Prostate Cancer

...enols alter the insulin-like, growth-factor-driven pathway present in prostate tumors and cause reduced expression of proteins known to cause the cancer to spread to other parts of the body. The green tea polyphenols also cut down on the amount of vascular endothelial growth factor in the tumors, a substance...

Gene to identify risk of stroke in sickle cell anemia

...troke. The others thus identified are genes in the pathway TGF-beta, as well as hemoglobin levels of the patients. The current study shows that stroke is complex phenomena will strong genetical influence....

New medicine for ovarian cancer

...and how the cell will respond to chemotherapy. AKT pathway remains highly active for a lot of different types of cancer, and yet does some functions healthy for the body as well. That was one of the reasons that the scientists did not target the enzyme AKT but a new enzyme. The researchers of the Fox Chase ...

High expression of interferon induces lupus disease

...found out that activation of the type I interferon pathway is more common among SLE patients who are most affected. The activation of the protein pathway is indicated by high levels of expression of interferon-inducible genes in the blood cells. When com...

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