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Tag: "mutation" at medical news

A new century of Alzheimer's disease research

...first to genetically engineer a mouse to express a mutation of the gene that controls tau production, and in 2000 they reported in Nature Genetics that the “tau” mouse develops the same kind of neurofibrillary tangles seen in human dementia. In 2001, the Mayo Clinic team produced another new engineered mouse,...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

...arch Institute (TGen) have identified the genetic mutation that may alter tumour cell proliferation, and make... The researchers say that they found a recurring mutation of the gene AKT1 in breast, colorectal, and ovarian cancers. The AKT pathway is among the most co...

France Steps Up Vigilance After Bird Flu Outbreak

..., the entire health system is ready to deal with a mutation of the virus" that could attack humans, said Bachelot on French television. Tests on the three swans found dead last week in northeast France confirmed the presence of the H5N1 strain of bird flu, the agriculture ministry said in a statement. Agr...

New "second-line" AIDS Drug Shows Promise in Trials

..., HIV can sidestep existing drugs with just a tiny mutation in a single amino acid. The treatment options narrow further if a patient is found to suffer bad side effects from these powerful molecules. The hope for etravirine is that it will open up a new front against resistant virus and raise the genetic...

Experts Propose New Criteria for Alzheimer's Diagnosis

...pecific pattern on PET of the brain, and a genetic mutation for AD within the immediate family. "These new criteria are centred on a clinical core of early and significant episodic memory impairment...the timeliness of these criteria is highlighted by the many drugs in development that are directed at chang...

Boffins Identify Gene That can Protect Humans from Nephronopthisis

...idney degeneration in NPHP. The genetic cause is a mutation in a gene called GLIS2," Nature Genetics quoted Mathias Treier, group leader at EMBL, as saying. GLIS2 protects adult kidney against cell death by turning off genes that trigger cell death, and that are necessary for the organ development. A chan...

New Therapies for Kidney Diseases

...idney degeneration in NPHP. The genetic cause is a mutation in a gene called GLIS2. GLIS2 normally prevents ... required during the development of the organ. A mutation interfering with GLIS2 function reactivates these harmful genes the result being that large numbers ...

Scientists Find New Way to Kill Antibiotic-resistant Bacteria

...n takes an antibiotic, any bug having a protective mutation against the drug survives. These drug-resistant microbes quickly accumulate useful mutations, and share them with other bacteria through conjugation. The researchers analysed the enzyme relaxase that plays a crucial role in conjugation. It starts ...

Scientists Identify New Genetic Mutation Behind Common Dementia

Scientists have identified a new gene mutation that is associated with frontotemporal dementia-a ...erme, Italy. The researchers discovered the new mutation in the gene named progranulin in an extended family in southern Italy. The genealogy of this family,...

Gallstone Gene Discovered by Research Team

... per cent. Cholesterol pump at full speed "The mutation concerns what is known as the ABCG8-gene," Dr. Gruenhage explains. "It contains the instructions for building a pump responsible for transporting the blood lipid cholesterol from the liver into the bile ducts." Most of the gallstones consist to a hig...

Natural Selection in Butterflies

... whether the suppressor gene emerged from a chance mutation from within the local population, or if it was int...migratory Southeast Asian butterflies in which the mutation had already been established. "We'll likely know more in three years' time when the exact location...

Key Mechanism to Emergence of Strep Bacteria

.... The researchers found that a specific genetic mutation in the M1T1 strep clone controls the shift to this...defense by pathogenic microbes. The same genetic mutation that allows the strep bacteria to acquire plasminogen and activate it throughout the body also incre...

Gene Variants for Crohn's Disease Identified

...nisms are not fully understood, said Baldassano, a mutation in the gene may weaken a cells ability to degrade cellular waste products, including bacteria. When unprocessed waste products pile up within the cell, they may stimulate the inflammatory response that characterizes Crohns disease. Although much...

Genetic Tests Could Help Decide the Right Anti-depressants

...rnal Science, Dr. Francis Lee identified a genetic mutation that could potentially predict patients responses ...rom person to person. If patients have a genetic mutation that results in either deficient enzyme activity or none, they would be likely to have serious side ...

Women With Few Older Female Relatives Face Cancer Threat

...els for breast cancer underestimated a deadly gene mutation in women with fewer than two female relatives who ...percent to 85 percent. Identifying women with this mutation who have already had breast cancer is important because their risk of recurrence is as high as 40 pe...

Neurological Disorder Gene Identified

...red pale tremor mice . The discovery of the gene mutation means a genetic test will be possible for people w...ntify the gene involved, called FIG4, and find the mutation responsible for the symptoms in less than three years. Thats a third of the time it might have taken...

Maths Theory Shows Genetic Pattern of Tumour Growth

...rmation, and then stay that way by turning off the mutation rate. Mathematical theory can help us understand...ur with set characteristics, then changed the cell mutation variable to see under which circumstances the tumour grew best. The mutation rate serves as the co...

Recall of the AIDS Drug Causes Panic in Zambia

...contaminant can cause cancerous tumors and genetic mutation that could harm unborn children if used during pregnancy. Purity Mwamba, an HIV-positive housewife in the capital, Lusaka, said: "I may not be on Viracept, but I am deeply concerned as a person living with HIV and on ARVs [antiretroviral drugs]. If ...

Ancient Ancestors Might Have Had a Clue to HIV

...th the protein, the scientists found that a single mutation made it better at recognizing HIV but worse at attaching to the ancient virus. This antiviral protein appears to be able to fight one virus or the other. Early humans evolved a defense against PtERV1, but left themselves wide open to the HIV pan...

Gene Therapy Awakens the Brain Despite Blindness from Birth

...o measure brain activity in blind dogs born with a mutation in gene RPE65, an essential molecule in the retinoid-visual cycle. The same mutation causes a blindness causing eye-retinal disorder in humans called Leber congenital amaurosis (LCA). ...

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Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2A first direct glimpse of photosynthesis in action 2
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