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Tag: "mutated" at medical news

A New Way to Treat Colon Cancer?

...by marking it for destruction. In tumor cells with mutated APC, CTPB is not destroyed; instead it accumulates in the cell. One function of CTBP is to turn off the process that converts vitamin A into retinoic acid in the cell. Retinoic acid is essential in cell differentiation – the function that determine...

Novel Techniques to Tackle Colon Cancer

...by marking it for destruction. In tumor cells with mutated APC, CTPB is not destroyed; instead it accumulates in the cell. One function of CTBP is to turn off the process that converts vitamin A into retinoic acid in the cell. Retinoic acid is essential in cell differentiation – the function that determine...

Stem cell trial to beat Batten Disease

...e age at which the symptoms develop. The inherited mutated gene determines the age of onset and rate of progression. Around 200-600 kids are affected by this disease in the U.S. "NCL patients lack an enzyme responsible for breaking down complex fat and protein compounds in the brain," lead researcher Dr. R...

Genetic Link To High Blood Pressure

...he said. The transcription factor that binds the mutated gene more easily is part of a cell signalling pathway. This pathway is activated by a protein called Ras, and mutations in Ras have been previously implicated in numerous human cancers. "When we blocked Ras signalling in the hypertensive rats, we w...

Virus Can Mutate lethally With Help Of Carbohydrates

...ple of years back these normally mild MVMp viruses mutated quite suddenly and became harmful to the defenseless mice. Agbandje-McKenna, who is associated with both UF's McKnight Brain Institute and the UF Genetic Institute explained “One or two changes in amino acids made the difference between a virus tha...

Genome Code Cracked for Breast and Colon Cancers

...ssue of Science Express,// identifies close to 200 mutated genes, now linked to these cancers, most of which ...s.' Some 200 genes were significantly mutated; the mutated genes in breast and colon cancers were almost completely distinct, suggesting very different pathway...

Cure for food allergies is less than a decade away

...Van Ree. Research is being done in the U.S. on the mutated version of the allergens on peanuts. GYT...

Netherlands to lift livestock restrictions over avian influenza

...o animals fell sick, the fear of the virus getting mutated was there. So, around 25,000 chickens were culled and livestock markets in the region and sales of animals from nearby farms were banned. These restrictions are to be lifted today. The ministry has made an announcement this week that from September...

Long-life genes - A new way to combat cancer…

...ory neurons in the brain. In the study, the team mutated a tumor suppressor gene called gld-1 in the worms, causing cells in the animals' gonads to divide rapidly and form germ-line tumors. These tumor cells, when left undisturbed, break out of the gonad and fill the body, killing the worm at around 9 days...

Researchers Find 'Secret Weapon' Used by SARS Virus

...akes a protein that breaks down RNA, and whether a mutated non-RNA-degrading SARS coronavirus could constitute a workable SARS vaccine are all issues that Makino's group intends to pursue. 'The main concern for everybody is whether SARS will come back,' Makino said. 'We want to be ready for it if it does.' ...

Research Leads to First Treatment for Drug-Resistant HIV

...of the virus that did not change as the rest of it mutated - the backbone of protease. "We designed this molecule top to bottom to interact with the protease backbone and deactivate the virus," he said. "This allows it to continue to be effective as the virus mutates, when other treatments would fail." M...

The Dengue Virus Unplugged

...minor changes that would alter its structures. The mutated RNAs were then inserted into mosquito cells or hamster cells to see if the viral RNA would be copied. To their surprise, the scientists found that the stem-loop or SLA sequence is essential for viral replication. Changes in even one or two buildin...

Finally, The First Ever Treatment for Drug-Resistant HIV

...of the virus that did not change as the rest of it mutated - the backbone of protease. "We designed this molecule top to bottom to interact with the protease backbone and deactivate the virus," he said. "This allows it to continue to be effective as the virus mutates, when other treatments would fail." ...

Emerging Therapies for Skin Cancer Treatment

...s genes and proteins in a cell. “Genes that become mutated activate pathways which tell cells to proliferate,” described Dr. Tsao. “In other words, the traffic lights are always green and the brakes are frequently dysfunctional, so the cancer cell keeps multiplying.” Based on this information, research effor...

Scientist Move A Step Closer To Treating Genetic Obesity

...ree years collecting data from cells, studying how mutated receptor cells reacted to the molecules that normally stimulate the body to eat or stop eating, said Zhimin Xiang, M.D., a UF biological scientist who led the experiment. Now, researchers are preparing to study mice that have been injected with the s...

Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias

...sts that drugs used to inhibit the activity of its mutated form might be used in leukemia patients with few serious side effects, the researchers said. A report on this finding appears in the July 19 online posting of the August 6 issue of Molecular and Cellular Biology (MCB). The researchers made their disc...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

... that p53 is an important tumor suppressor that is mutated in the majority of human cancers, this will undoub...ming a dimer tracks to a part of the protein often mutated in cancers. This suggests that the interface between the two proteins of the dimer is likely as impo...

New Sleep Gene Discovery Wakes Up Scientists

...cell cultures and observed that for those with the mutated gene, the protein only took a couple hours to degrade. For the normal gene, it took 8-10 hours. Next, Virshup said, his team will begin testing ways to regulate the circadian rhythm in mice, a necessary step before new drugs can be developed. (So...

Breakthrough In Parkinson's research

...of Missouri, Kansas City, they demonstrated that a mutated form of alpha-synuclein destroyed a key protein in this process, resulting in cell death. The next step was to find a gene that could produce this key transport protein, in order to save the cells. "We were surprised that when we tested this gene...

New Drugs Could Save Lung Cancer Patients

...by restricting tumour growth in people who carry a mutated gene. It is believed that around 30 percent of people with cancer could have this gene and the mutation is thought to be connected to smoking. Of this group, 80 per cent of people tested benefited from the drugs, Dr Jeffrey Settleman, a US scienti...

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