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Tag: "mutated" at medical news

New Insights into Antimalarial Drug Resistance

...his study, they know that PfMDR1 is dependent on mutated PfCRT , and probably doesnt act independently. The contribution of PfMDR1 to anti-malarial drug resistance is important, but much smaller than what many researchers thought it would be, said Roepe. Before the discovery of PfCRT, many thought PfM...

A New Target for Cancer Therapy-Integrin Alpha7 Molecule

... School of Medicine, examined whether this gene is mutated in specimens of various human cancers as well as w...tegrin alpha7 protein or the protein was naturally mutated in cells, those cells lost their inhibitory signals for both cell migration and proliferation. Th...

New Bird Flu Case in Hong Kong

...nland China, where it is believed the strain first mutated into a form deadly to humans. Hong Kong was the scene of the world's first reported major bird flu outbreak among humans in 1997, when six people died. World Health Organisation experts say a bird flu pandemic among humans would kill millions wor...

Chinas Blue Ear Virus-no Hogwash

... worldwide, posing no threat to humans. But it has mutated in China, making it hard to identify and becoming more deadly to pigs, says Jia. "This variation of Blue Ear disease is a completely new variation," informs Jia. "It is the first time our country and the world has experienced this kind of the disea...

Altered Protein Structure was Found in Autism Patients

... of proteins that are encoded by genes known to be mutated in certain patients with autism. The neuroligins, and their partner proteins, the neurexins, are involved in the junctions, or synapses, through which cells of the nervous system signal to one another and to non-neuronal tissues such as muscle. These...

Gene Mutations Leave Caucasians Prone To Heart Diseases And Diabetes

... 25 percent of Caucasians they tested carrying two mutated copies of 9q21 and had a 30 to 40 percent higher risk of coronary heart disease than people without the mutation. Half the people had one copy and they had a 15 percent to 20 percent higher risk of heart disease. It was also observed that Africans...

New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs

...d that only tumors in which the EGFR gene has been mutated in a way that magnifies the cells' response to the growth factor, a process that fuels tumor growth, were sensitive to treatment with these drugs. Although tumors that respond to EGFR inhibitors do so rapidly and dramatically, eventually the tumors...

Head and Neck Cancer Vaccine Targets Proteins to Create Immune Response

...arget a tumor suppressor gene called p53, which is mutated in most cancers and associated with poor clinical outcomes. Previous research has determined that mutated p53 also expresses unaltered, or "wild-type," p53 peptides in tumors. When presented on dendritic ce...

Drug Used to Prevent HIV Transmission from Mother to Child Damages DNA

...s in the K-ras and p53 cancer genes that are often mutated in human lung tumors. The development of lung cancer in these mice suggests that the incorporation of AZT or its metabolites into DNA, oxidative stress, and genomic instability may be the contributing factors to the pattern of mutations observed in t...

More Mutations Of Gene That Cause Skin Disorders And Asthma Discovered

...e." Last year the team had discovered that the mutated gene, which is carried by five million people in B... the skin, provides a preventative barrier. In the mutated genes filaggrin is missing which causes inflammation. The researchers searched through filaggrin ...

Drug Used to Prevent HIV Transmission from Mother to Child Damages DNA

...s in the K-ras and p53 cancer genes that are often mutated in human lung tumors. The development of lung cancer in these mice suggests that the incorporation of AZT or its metabolites into DNA, oxidative stress, and genomic instability may be the contributing factors to the pattern of mutations observed in t...

Brain Tissue Reveals Possible Genetic Trigger for Schizophrenia

...ophrenia, many cancers, and diabetes – we find not mutated proteins, but correctly formed proteins in incorrect amounts,” said study lead author and UNC professor of psychiatry Dr. Diana Perkins. The research appears this week in the online edition of the journal Genome Biology. “To our knowledge this stud...

Severe Mental Retardation Gene Mutation Identified

...ne found in those with severe retardation as being mutated to the point of entirely losing function. "ZDHH...slational modification enzyme has been found to be mutated in X-linked mental retardation, the researchers expect to find similar genes related to other mental...

A Novel Treatment for KSHV-infected Lymphomas

...twork referred to as the p53 pathway. TP53 gene is mutated or deleted in 50% of all malignant tumors. A recently discovered strategy for p53 activation targets the interaction of p53 with its negative regulator MDM2. This is based on a potent and selective small-molecule inhibitor of the p53–MDM2 interact...

Gene Study Offers Hope of Potent Anti-cancer Drugs

...r Stratton. "We have found a much larger number of mutated driver genes produced by a wider range of forces than we expected. It's important because the more cancer genes we find, the more targets we'll have in terms of potential new drugs." The study, published in the journal Nature, compared the genetic ...

MSU Research Strengthens Link Between Smoking, Pancreatic Cancer

...by triggering the stem cell that’s been previously mutated to proliferate,” said Trosko, a professor of pedia...ght that specific PAHs produced by burning tobacco mutated genes which, in turn, triggered the cancer mechanism. “We take issue with this interpretation,” Tr...

Scientists Identify 120 New Cancer Genes

... Stratton. "We have found a much larger number of mutated driver genes produced by a wider range of forces than we expected. It's important because the more cancer genes we find, the more targets we'll have in terms of potential new drugs," Stratton was quoted as saying. The researchers in the study compar...

Biologists Trace Cause Of Early Blindness To Tissue Defect

...n trait, we select for the trait, then go find the mutated gene that caused it. We let nature and the organism tell us what’s important and what’s not.” Perkins says the next steps for his laboratory involve continuing investigation into protein transport processes and trying to find additional zebrafish m...

Weed Killer Plays a Pivotal Role in Those With Genetic Vulnerability to Parkinson’

...hesis. It was found that some flies, which had a mutated gene that resulted in the production of very littl...tible to the effects of paraquat, while those with mutated genes that resulted in the production of too much dopamine were in fact resistant. Another interes...

Leukemia Drug Turns Mini-Molecules Up, Cancer Genes Down

...ausing gene. (Oncogenes are normal genes that when mutated lead to cancer.) Researchers at the Ohio State University Comprehensive Cancer Center led the study, which was published in a recent issue of the journal Oncogene. “The findings are important because they tell us that some miRNAs switch off gen...

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