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Tag: "mutated" at medical news

Prions Prevent Alzheimers Disease

...ctive role of normal prion proteins is provided by mutated versions that are linked to genetic forms of prion disease because beta-amyloid fragments are able to form when the normal prion protein is corrupted by genetic mutation. Professor Hooper concludes: Until now, the normal function of prion proteins ...

First Genetically Engineered Maize Resistant to Maize Streak Virus Produced in S. Africa

...ocess. The group at the University of Cape Town mutated a viral gene that encodes a protein that the virus... infects one of these transgenic maize plants, the mutated protein, which is expressed at a high level, prevents the virus from replicating and killing the pla...

Mutated Gene Zaps Pancreas Cancer in Mice

A mutated gene named Bik can shrink or kill tumors in the pancreas of mice, US researchers said in a study published Monday, offering hope for one of the deadliest human cancers The mutant gene named Bik expresses a protein that forces cancer cells to kill t...

Scientists Identify New Genetic Mutation Behind Common Dementia

...mily did not have any cases with two copies of the mutated gene. "We would have expected to see cases with two copies of the mutated gene, especially since this family shares much of the same genetic material, as there have been at l...

Key Mechanism to Emergence of Strep Bacteria

...rep clone, discovering that the bacteria routinely mutated to the invasive form, then spread throughout the body to produce a fatal infection. When the researchers eliminated the single bacteriophage gene encoding the neutrophil resistance factor, the M1T1 strep strain lost its ability to undergo the dange...

Researchers Find New Target for Anti-cancer Drugs

... integral in normal cell growth. When this gene is mutated and becomes overactive, it can lead to the unregul... ras gene, known as an oncogene when it is in this mutated state, has been implicated in several different cancers, including those of the pancreas and lungs. ...

Scientists Establish Link Between Foie Gras and Disease

...ase process that involves the deposit of normal or mutated proteins that have become misfolded. It further says that in unstable state, such proteins from fibrils that are deposited into vital organs like the heart, kidneys, liver, pancreas and brain, which may lead to organ failure and eventually death. A...

Researchers Reverse Mental Retardation Symptoms in Mice

...enetic cause of autism. The condition, tied to a mutated X chromosome gene called fragile X mental retardation 1 (FMR1) gene, causes mild learning disabilities to severe autism. Researchers identified a key enzyme, a chemical reaction-inducing protein as a possible target for an FXS drug. The enzyme, cal...

Research Shows Way for Drug Therapy for Autism

...netic cause of autism. "The condition, tied to a mutated gene in the X chromosome, causes mild learning disabilities to severe autism," researcher Sumantra Chatterji at NCBS told IANS. Presently, there is no effective treatment for FXS and other types of autism affecting all races and ethnic groups, he sai...

Highly Effective Method for Screening Drug-resistant Forms of HIV Developed

...f the tests, Dr. Bushman examined seven samples of mutated strains of HIV, including three HIV samples from patients who had experienced antiretroviral multi-drug resistance. The DNA bar coding, wherein different DNA molecules are indexed using DNA sequence tags, helped the researcher map multiple sequence...

Loss of Antenna Leads to Cancer in Insects

...t year showed that important gene, PKHD1, commonly mutated in PKD has also been found as a target of mutation in colorectal cancer....

Gene Mutations Leave Caucasians Prone To Heart Diseases And Diabetes

... 25 percent of Caucasians they tested carrying two mutated copies of 9q21 and had a 30 to 40 percent higher risk of coronary heart disease than people without the mutation. Half the people had one copy and they had a 15 percent to 20 percent higher risk of heart disease. It was also observed that Africans...

Protein Interactions Targets for Huntington Disease Therapy

... more than 200 new proteins that interact with the mutated protein that causes Huntingtons disease opens the door to developing treatments for the fatal neurodegenerative disorder, said a Baylor College of Medicine researcher who took part in the work that appears online today in the journal Public Library ...

Gene Thought to Help Kill Cancer Cells may Actually Help Them Thrive

...ed sword. Chemotherapy patients whose tumors had a mutated p53 gene that didn't work had a much better survival rate than those who had normal p53. In the study, researchers took malignant and benign ovarian tumors straight from the operating room and compared their gene expression profiles. Some of the ca...

Scientists Identify New Breast Cancer Gene

...ses sites of DNA damage that breast-cancer-causing mutated forms of BRCA1 cannot recognise," says co-senior author Dr. Roger Greenberg, Assistant Professor of Cancer Biology at Penn. "Now we have gained a partial understanding of the molecular basis between cancer-causing BRCA1 failures to fix DNA damage v...

New Mouse Model to Aid in Cancer-causing Genes Hunt

...o genes, FBXW7 and PTEN, to be commonly deleted or mutated in this type of human cancer. "We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passenger' even...

Scientists Identify Four Genes That Raise the Risk of Breast Cancer

...y patient. One of the new genes, when found in a mutated form, increases the risk of developing the cancer ...ded risk of cancer developing in any woman who has mutated versions of them, they are much more common, and higher the chances of a woman developing breast can...

Mutant Parasites, Unable to Infect Hosts, Highlight Virulence Genes

... researchers identified nearly 40 genes that, when mutated in the common parasite Toxoplasma gondii, prevented the parasite from forming an infection in the brains of mice. These potential "virulence factors" offer a smorgasbord of promising targets for developing drugs that could block or treat human parasi...

Genetic Code That Helps Kill Colon Cancer Cells Identified

...n cancer cells. "P53 is one of the most commonly mutated genes in human cancers. And there is now a great deal of evidence that microRNAs themselves can act to either promote cancer or to stop cancer spread," says Mendell. During the study, the researchers chemically damaged the DNA of two sets of colon ...

Genetic Testing Helping Cancer Survivors Fight For Their Loved Ones

... risk of developing cancer because of an inherited mutated gene. With a combination of increased surveillance...mber, the testing may find that they do not have a mutated gene, and can give peace of mind....

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