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Tag: "mutants" at medical news

Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA

..., less expensive technique to hunt illness-causing mutants in large, non-gene stretches of DNA. The development of the new technique is important because diseases can result not only from mutant genes, but also from mutations of other DNA that controls genes. "Diseases are known to occur as a consequence ...

Another Sexual Attraction is Possible ...

...ic "language" is likely to decrease the fitness of mutants that might use slightly different signals. Such "atypical" individuals would either - and most probably - die without leaving any offspring, or - in the unlikely event that they find a mutant partner - they might found a new line that may eventually ...

Theory of How HIV Attacks is Wrong: Study

...n - in a Darwinian sense -- over time for 'fitter' mutants of the virus in an infected person," said lead author Andrew Yates of Emory University in Atlanta, Georgia. "There are several ways the virus could become fitter - for example by being able to infect new cells more readily, or by infected cells pro...

Highly Effective Method for Screening Drug-resistant Forms of HIV Developed

...elped the researcher map multiple sequences of HIV mutants simultaneously. He identified drug-resistant mutations by using a new DNA sequencing technique called pyrosequencing, which enables determination of millions of bases of a DNA sequence in a single one-day experiment. When the two methods were combi...

Malfunction of Gene Causes Schizophrenia, Depression

... theory, they screened a large population of mouse mutants to isolate two with different mutations in DISC1. They found that, indeed, one of the mutant mouse strains exhibited abnormal behavior and memory deficiencies resembling the symptoms of schizophrenia in humans. Additionally, these symptoms could be...

Genome of Botulism Bacterium Revealed

..."Even after decades of research, only a handful of mutants had been made in clostridia, and none in C. botulinum," Professor Minton explains. "We have developed a highly efficient system, the ClosTron, with which we have, in a few months, knocked out over 30 genes in four different clostridial species, inclu...

Malfunction of Gene Causes Schizophrenia, Depression

... theory, they screened a large population of mouse mutants to isolate two with different mutations in DISC1. They found that, indeed, one of the mutant mouse strains exhibited abnormal behavior and memory deficiencies resembling the symptoms of schizophrenia in humans. Additionally, these symptoms could be...

Scientists Explore Ways to Lure Viruses to Their Death

... Dr. Turner and his colleagues reasoned that these mutants might act as traps for phi-6 viruses, luring them into a dead end. Because Dr. Turner’s team study bacteria instead of mice, they can run many more experiments to discover the ecological rules of viral traps. Dr. Finberg’s team needed a year to des...

New Ribosome Finding Could Lead to Antiviral Therapies

...nt to certain antibiotics. Understanding how these mutants affect the interactions between ribosomes and factors that lead to drug resistance can provide the foundation for design of new antibacterials to counter resistance of pathogens to drugs,” said Dinman. “This study also provides a basis for deeper ins...

Yale Researchers Named Ellison Foundation Senior Scholars in Aging

...said Slack. Consistent with the lifespan analysis, mutants he studied were stress-sensitive and aged prematurely. Since some of these genes coded for small non-coding RNAs called microRNAs, his work provided some of the best evidence for a novel role for microRNAs in aging, and opened the potential of using ...

Fruit Flies May Pave Way to New Treatments for Age-related Heart Disease

...fly for a different purpose. We then studied these mutants with the new heart function assays that Ocorr was developing in my lab. Subsequently, we worked with Martin Fink and Wayne Giles at UCSD to develop a computer program that would allow the automated quantification of heart beat parameters and arrhythm...

The Story Behind the Shape of the Heart

...ac function influences cell shape. Using zebrafish mutants with functional defects, they found that both blood flow and cardiac contractility influence cardiac cell shape. The researchers propose that a balance of the cell’s internal forces (through contractility) with external forces (such as blood flow) is...

New Antibody for EGFR Causes Lung Cancer Regression

...duals with lung cancer caused by the distinct EGFR mutants can be examined using two mouse models of lung cancer, one driven by expression of EGFR with a mutation in the intracellular part of the protein and one driven by expression of the EGFRvIII mutant. In a study, Kwok-Kin Wong and colleagues from the ...

Study Uncovers Mutation Responsible for Noonan Syndrome

...1, the scientists made recombinant versions of the mutants and expressed them in mammalian cells, where it was discovered that they promoted excessive activation of RAS and its downstream target, MAP kinase, the same pathway activated by PTPN11 mutations. 'These results are the first example of activating ...

Parkinson's Mutation Stunts Neurons

...tant forms of the enzyme, they discovered that the mutants showed higher-than-normal enzymatic kinase activity compared to the normal version. When they introduced the mutant forms into cultures of neurons, they saw a reduction in the growth and branching of the neurons. Such growth is critical for the neuro...

Engineering Nutrient-Rich Plants Made For Feasible By New Findings

...metals in Arabidopsis seed. Examination of various mutants is shedding light on which transporters influence the distribution of important nutrients such as Iron in the seed. Such information should aid the development of nutrient-rich seed, beneficially affecting human nutrition and health. This research sh...

Growth Factors Help Neurons to Reach Their Correct Destination

...all and failed to reach their destination in mouse mutants lacking the sensor molecule. Finally, using mice engineered to express a fluorescent protein in MMCm neurons, the investigators demonstrated that only the glowing neurons extended axons in the direction of target cells expressing FGF. ‘After a lot of...

Molecular Basis Of ALS Found

... fundamental molecular mechanism by which the SOD1 mutants form aggregates is not clear. Six years ago Siddique and Han-Xiang Deng, M.D., associate professor of neurology at the Feinberg School, started to develop and analyze various SOD1 transgenic mouse models and found, as they report in the first of th...

New Screening Techniques to Lead Advances In Pain Therapy

... 14,000 mutants. The scientists have isolated five mutants that specifically affect menthol activity. The results were published in the journal Nature Neuroscience. This new understanding could lead to potential advances in pain therapy. This new methodology can be used to study the activation mechanism of...

Designer Strawberries

... are now in a position to generate a collection of mutants that will serve as an invaluable tool not only for discovering new genes in the Rosaceae family but also for establishing the functions of these genes through high-throughput screening methods." The electronic preprint of this article entitled "Hig...

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