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Tag: "mutant" at medical news

Prestigious Wilson Award Goes To Yale Cell Biologist Joel Rosenbaum

... Medical School examined kidney tubules of the PKD mutant mouse with the scanning electron microscope, they ...or not functioning, situs inversus results. In the mutant mouse with defective or missing cilia, situs inversus occurs as well as PKD in many cases. Many of t...

Parkinson's Mutation Stunts Neurons

... pinpointed the malfunction of the protein made by mutant forms of the gene called LRRK2 and how it affects ... their experiments, when the researchers generated mutant forms of the enzyme, they discovered that the mutants showed higher-than-normal enzymatic kinase act...

Zinc – A New Key Player In Brain Circuitr

...g among the neurons. Significantly, they found the mutant mouse shows the same exaggerated response to noise...riments, the researchers produced mice harboring a mutant form of a gene for a receptor for zinc in neurons--thereby compromising the neurons' ability to resp...

Limb Regeneration Exists Innately In All Vertebrates – Says Researc

...l regeneration. And, conversely, when they treated mutant adult zebrafish that cannot regenerate with the excitatory agent, the ability to regenerate their fins was rescued, Belmonte says. Using an inhibitory agent on frogs before the regeneration-enabled developmental window closed resulted in loss of th...

Non-Steroidal Anti-Inflammatory Drugs Can Cause Liver Damages

...h alpha-1-AT deficiency. Greater expression of the mutant alpha-1-ATZ gene and increased amounts of alpha-1-ATZ protein in the liver accompanied the increase in liver injury in the experimental mice given the NSAID. "These data demonstrate that environmental factors such as drug administration can affect ...

Chronic Kidney Disease Related To Mutant Gene

...hospholipase C epsilon or PLCE1. Discovering the mutant gene is crucial to scientists because PLCE1 impacts the development of podocytes – that are unique cells that have an important role in the kidney's function in the body. To parents of infants with inherited PLCE1 mutations, the study is especiall...

Gene Transfer Using Mutant Form of Good Cholesterol Cuts Vascular Plaque and Inflammation

Transfer of a gene that produces a mutant form of good cholesterol provides significantly be...n the blood stream. Apolipoprotein A-I Milano is a mutant form, which was originally found in a small number of individuals in Italy who appear to be protecte...

Virus Can Mutate lethally With Help Of Carbohydrates

...Mi, harmless MVMp and three potentially dangerous, mutant strains of MVMp. They claimed to have found that t...me three glycans on the plate. However, one of the mutant MVMp viruses also bound to an additional glycan and that one was associated with the more dangerous ...

Genome Code Cracked for Breast and Colon Cancers

...Hopkins team also found that the average number of mutant genes in each cancer is about 100, and at least 20...rs types, charting the pathways through which each mutant gene acts, and looking for common mutations that can be targeted with cancer drugs or used to detect...

The Fruit Fly to Aid in Cancer Research

...an use it to silence the function of any normal or mutant gene at will. This new technology has the potential to change forever the way researchers and doctors fight cancer and other diseases. "By combining the benefits of Drosophila RNAi screens with the functional analysis in human cell culture models of...

Long-life genes - A new way to combat cancer…

...nd its activity is essential to extend life in the mutant daf-2 worms. This affects the aging process by switching other genes on and off. These genes encode proteins that may be responsible for the prevention or repair of damage to other proteins in the cell. These interactions trigger a cascade of cellula...

Cellular System Causing Destruction Of Faulty Proteins In Cystic Fibrosis Identified

... normally because their bodies quickly destroy the mutant protein. "Most cases of CF are caused by the inability of faulty CFTR to get in the correct shape, which leads cells to place it in the trash bin," said senior author Dr. Douglas Cyr, professor of cell and developmental biology at UNC School of Me...

Researchers Find 'Secret Weapon' Used by SARS Virus

...t of questions — among them, whether we can make a mutant form of SARS coronavirus that lacks the ability to degrade messenger RNA, which could ultimately lead to the creation of a live attenuated vaccine for SARS.' Although many viruses interfere with host cells making messenger RNA or translating it int...

p53, the Guardian of Our Genome

...d Li-Fraumeni syndrome, where people are born with mutant p53 in all their cells. Affected individuals are extremely vulnerable to cancer, tending to develop tumors. p53 is kept under tight control by another gene called mdm2 that switches it on and off. Mdm2 is what stops p53 killing all our cells. Hence ...

Molecular Therapy Holds Promise in the Treatment of Amyotrophic Lateral Sclerosis

... diagnosis. Neurotoxicity from an accumulation of mutant proteins is believed to be at the root of many neu... effectively silences the gene that codes for this mutant protein – found in the cells of patients with inherited forms of ALS. In this disease, selective ki...

Active Life Decelerates Alzheimer's

...ology of TgCRND8 mice. These mice, which express a mutant form of A? found in some Alzheimer's patients, develop Alzheimer-like features including A? plaques and cognitive deficits. To study the effects of enrichment, mice were housed in either standard cages or enriched cages, similar to the standard but w...

"Miracle" Cancer Drug Gleevec Can be Toxic to the Heart

...ited the normal enzyme but not the mutant, and the mutant ABL “rescued” the heart cells from the toxic effects of Gleevec, proving that ABL is the relevant target. As a result, second-generation Gleevec drugs might also have similar toxicities in the heart. “This finding is a big surprise and there may be...

Scientists Uncover The Secret Behind The Speed In Nerve cells Conduction

... University's James Rothman and colleagues created mutant cells with SNAREs on the outside rather than the inside, and they used the cells to show that complexin could inhibit fusion that would otherwise be expected to proceed. "Complexin is the brake," McNew said. "It says, 'Stop. Don't go any further un...

Researchers Have Linked Rett Syndrome to Mitochondrial Gene

...span of a mouse is 2 years). The team compared the mutant mice to normal mice in search of genes that were o...by about 10,000 different genes from the brains of mutant mice that were almost 10 weeks old. Compared to normal animals of the same age, the team found more ...

Animal Study Found Cure For Huntington Disease

... discovered that by preventing the cleavage of the mutant huntingtin protein responsible for Huntington dise... symptoms including the inevitable cleavage of the mutant huntingtin protein. In the study, researchers confirmed that the deadly cleavage is caused by a key ...

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