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Tag: "mutant" at medical news

South-East Asia Flooded With Spurious Drugs

...tality rate are responsible for the development of mutant strains of virus. According to experts in the field, China is the headquarters for this trade. The distribution network of spurious drugs trade is similar to heroin network from China to Hong Kong via Thailand. JYT...

Mutation In PALB2 Elevates Risk of Cancer

...ee families. It was later showed that the relevant mutant protein is deficient in its ability to support the kinds of DNA damage responses in which PALB2 normally participates. The mutation was further also investigated in 1,918 specimens from an unselected series of Finnish breast cancer individuals. Thi...

Early Treatment May Thwart Mad Cow-Type Disease

A number of brain diseases caused by mutant prion proteins, such as mad cow disease or scrapie... prion protein to follow suit. The accumulation of mutant prions is toxic to brain cells, eventually turning the brain to mush. Now UK researchers report t...

Growth Factors Given With Chemotherapy may Increase Risk of Blood Diseases

...t the cell to die, but growth factors may save the mutant cell, allowing it to develop into a cancer called acute myelocytic leukemia (AML). There's also concern about the risk of a disease called myelodysplastic syndrome (MDS), in which the bone marrow—which produces blood cells—does not function normally....

Salk Scientists - Links Between Cancer and Aging

...either a functional copy of the WRN gene, which is mutant or nonfunctional in Werner Syndrome, or a gene encoding the protein telomerase, which elongates short or missing telomeres. After cells divided several times, their DNA was reexamined for the type of damage associated with both aging and cancer. Ce...

Food Odors Linked With Lifespan in Fruit Flies

...They found that in all cases, the longevity of the mutant flies was considerably greater than their wild-typ...They found that in all cases, the longevity of the mutant flies was considerably greater than their wild-type controls. The paper will be published by Scie...

UCLA Find Yields Further Insight into Causes of Parkinson’s Diseas

...r dysfunction in the fly. Thus, the interaction of mutant parkin with dopamine may be key to understanding t... implicated in Parkinson's disease. "We put the mutant parkin in all different kinds of tissues and in different kinds of neurons, and it was toxic only to...

Gene Behind Lincoln’s Diseas

...-millimeter-long nematode worms were bred with the mutant gene, they lacked beta spectrin, resulting in brea...e axons between nerve cells." Jorgensen says the mutant gene also may be involved in other neurodegenerative diseases and in brain damage that results from ...

Scientists Find Potential Weakness In Plague Germ

...to limit the spread of an infection. They made a mutant version of Yersinia without that protein. When mice were exposed to it, the bacterium managed to begin infection normally but the disease never progressed into the second phase and the mice were not dying from pneumonia. The mice did eventually die...

New Antibody for EGFR Causes Lung Cancer Regression

...e. However, not all individuals// express the same mutant EGFR, for example, some have a mutation that affec...e treatment of patients with lung cancer driven by mutant forms of EGFR, in particular the EGFRvIII mutant. Source-Eurekalert...

New Strategy for the Treatment of CML

...with CML. It works by inhibiting the activity of a mutant protein, known as Bcr/ABl, which is responsible for this disease. However, despite initial success, patients eventually become resistant to imatinib mesylate. According to Steven Grant, M.D., Massey's associate director for translational research a...

A New Test to Detect Drug-resistant HIV Strains

... virus. The test is designed to pick up a common mutant strain, which offers resistance to one of the first-line treatments for HIV. It would then enable doctors to recommend other medicines if patients test positive for drug-resistant strain. PRI...

Researchers Discovered the Gene Responsible for Brittle Bone Disease

...m dominant mutations, requiring only one copy of a mutant gene to cause bone disease. The NIH researchers di...lable for genetic testing, each parent carried one mutant CRTAP gene and one normal CRTAP gene, the classical pattern of recessive inheritance. Dr. Marini add...

Regrowth of Zebrafish's Tail Fin may Offer Clues for Treating Human Injuries

...n, and inhibits fin regeneration. Fish that have a mutant Wnt5b protein regenerate missing tails very quickly. Too much of another related protein, Wnt8, also increases cell proliferation in the regenerating fin. “We can actually increase the rate of regeneration by turning on these genes,” Moon said. T...

Protein Essential for Kidney-to-Bladder Urine Transfer

...ls form rings around the tube of the ureter. "In mutant mice, the longitudinal muscle is fine, but the circular muscle is either missing or has become longitudinal," Miner says. Swat and Miner are planning to collaborate with geneticists to see if functional obstruction in humans can be linked to altera...

Clues to Allay Aging

...when mutation of XPF gene happens in the body. The mutant mice showed physically retardation to some extent after birth. Later on there was stunted growth after a couple of weeks. All the transgenic mice died when they were four weeks old. The XPF gene is not the only gene that plays a role in aging or i...

Researchers Create Genetically-Matched Embryonic Stem Cells for Transplantation

... of their genome that contain duplicated copies of mutant genes that have been linked with malignancies or abnormal tissue growth. “Right now this technique is useful for basic research, but we are hopeful that parthenogenetic cells might prove useful for therapies,” Daley says. “Our cells produce normal ...

From a Lowly Yeast, Researchers Divine a Clue to Human Disease

... Sen1 that does not see the stop signal. "The Sen1 mutant reads right through the stop sign and keeps going," Brow says. Without a properly functional Sen1, RNA polymerase II "reads through" the end of the gene and builds longer and longer RNA messages. "In some cases it doesn't have a big effect," Brow s...

Link Between Huntington’s and Abnormal Cholesterol Levels in Brain Establishe

...Cynthia McMurrary, Ph.D. “Our discovery that the mutant Huntington’s disease protein derails the cholester...ional disturbances and mental deterioration. The mutant protein of Huntington’s attacks the railroad system of brain cells and impairs transport of essentia...

NMNAT Protein Protects Against Nerve Cell Degeneration

... whether NMNAT was actually protective by studying mutant forms of it in fruit flies or Drosophila melanogaster, a commonly used model organism. NMNAT exists in a single state in the fruit fly, and there is only one form of it. When Zhai, Bellen and colleagues bred flies that lack the protein in their vis...

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