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Tag: "mutant" at medical news

A new century of Alzheimer's disease research

... on-off “switch”¬ to control the expression of the mutant gene so that the disease could be studied at both early and late stages. During these experiments, the Mayo Clinic group and their collaborators were stunned to find that they could reverse tau pathology early on, and restore memory to mice that ha...

Mutated Gene Zaps Pancreas Cancer in Mice

... hope for one of the deadliest human cancers The mutant gene named Bik expresses a protein that forces can...least half those who received the aggressive BikDD mutant gene survived for 14 months with no signs of cancer. "This vehicle, or vector, is so targeted and ...

Gene Therapy Eradicates Pancreatic Cancer in Mice

...udy, the researchers loaded the VISA system with a mutant version of a gene named BiK, which expresses a pro...ent types of mice. Boffins created the more lethal mutant and named it BikDD. Untreated control mice in both experiments all died within 40 days, while mice...

Genome Annotation by Mutation

... blueprint , yet diseases can result not only from mutant genes, but from mutations of other DNA that contro...ting DNA, costing $200 to create each mouse with a mutant gene or other DNA sequence, although the savings are not proportionate because more mutant mice must...

Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA

...mportant because diseases can result not only from mutant genes, but also from mutations of other DNA that c...hat the savings are not proportionate because more mutant mice must be bred to obtain desired mutants....

Key Signaling Molecules in New Teeth Formation Identified

... the stem cell niche, using a combination of mouse mutant analyses , organ culture experiments, and gene expression studies, although mammals have a limited capacity to regenerate teeth, mouse incisors contain stem cells and grow continuously throughout life. The researchers show that signals from the adj...

Challenges in Entecavir Drug Treatment

...and HIV who was treated with entecavir developed a mutant strain of HIV that is resistant to the antiviral drugs lamivudine and emtricitabine. Entecavir is manufactured by Bristol-Myers Squibb and is marketed under the trade name Baraclude. The research team was led by Chloe Thio and Howard Hughes Medical...

Another Sexual Attraction is Possible ...

...pring, or - in the unlikely event that they find a mutant partner - they might found a new line that may eve...h, the offspring of such parents would inherit the mutant communication system of their parents, which could "spark" the divergence leading to the formation o...

Boffins a Step Closer to Solving Puzzle of Lou Gehrig's Disease

...es and learn what makes them toxic. "Some of the mutant proteins are very different from the normal protei...cular biology to redesign the protein and make new mutant forms of the protein that would have different inorganic properties," she said. "We were making mu...

Malfunction of Gene Causes Schizophrenia, Depression

...sion. The researchers' theory was that different mutant variations of DISC1 might have different pathologi...ns in DISC1. They found that, indeed, one of the mutant mouse strains exhibited abnormal behavior and memory deficiencies resembling the symptoms of schizop...

Scientists Discover Rare gene-for-gene Interaction That Helps Bacteria Kill Their Host

...To test their findings, the researchers produced a mutant Photorhabdus that is unable to make ST. Without ST, the bacteria were less virulent. The researchers then used a technique known RNA interference to prevent the insects from producing the phenoloxidase enzyme. These insects were more susceptible to r...

Master Regulatory Gene of Epithelial Stem Cells Identified

...ell-known tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells. The findings also have implications for cancers of the skin, breast and prostate, which are among the most common human malignancies. The role of p63 in epithelial stem cells has been controve...

Study Reveals Little-known Cell Networks Vital to Circadian Rhythm

...rhythm. In fact, the circadian defects observed in mutant oscillators were clearly more extreme when measured at the tissue and cell levels than demonstrated by behavioral observations. "Because single cells are ordinarily capable of functioning as autonomous oscillators," Kay noted, "our previous underst...

Clock Gene Plays Role in Weight Gain, Study Finds

...hought that over time, as we continued to feed the mutant mice the high fat diet, that they would eventually gain weight at some expected rate, but it never happened. These mice continued to stay slim while the normal mice nearly doubled in weight and developed fatty livers. Green said it is possible that...

DNA-damage Test Could Aid Drug Development

... existing test. Additionally, he experimented with mutant mice created by Samsons lab that are deficient in certain DNA-repair systems. The bone marrow cells derived from these mice, and the cells cultured from that bone marrow, proved more sensitive to the toxic agents than were the cultured cells from nor...

$5M Gift Will Attack Lou Gehrig's Disease

...nce, to keep the cells of ALS patients from making mutant proteins involved in the disease....

Nervous Systems of Insects may Offer Clues on Neurodegenerative Diseases

...a second research project, which involves studying mutant flies that lack the ability to add the terminal su...ing in seizures and paralysis. The nerves of the mutant flies are defective in electrical signaling, which impairs their ability to communicate with one ano...

Mutant Parasites, Unable to Infect Hosts, Highlight Virulence Genes

...in the parasites, then looking to see which of the mutant parasites could no longer infect host brains. "L... a trafficking breakdown that likely underlies the mutant parasite's inability to effectively sicken its host. This study is the first evidence that this ty...

Protein in Human Sperm may Hold Clues to Male Infertility

...art of the study, researchers examined sperms from mutant mice with defective versions of the protein. They found that the sperms of mutant mice had very low fertility as compared to those of normal mice. '(The protein) is involved in the...

Mouse Model Points to Strategy for Treating Rare Muscle Disease & Kidney Disorders

...n have gone on to develop muscle weakness, but the mutant mice remain smaller than their unaffected siblings...ly ongoing in Dr. Huizings laboratory to study the mutant mice until they reach an older age when researchers can assess any onset of muscle weakness. In addi...

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