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Tag: "mouse" at medical news

A new century of Alzheimer's disease research

...plaque, these scientists were already developing a mouse that spontaneously overproduces tau proteins. May...searchers were the first to genetically engineer a mouse to express a mutation of the gene that controls tau production, and in 2000 they reported in Nature ...

Researchers Discover How Cancer Evades the Immune System

...hers studied the expression of these genes in five mouse tumour models for breast cancer, leukaemia, colon cancer, lung cancer and renal cell carcinoma. When they compared two of these immune signatures with corresponding human tumours thereafter, they found that the immune signatures of each of the human ...

Scientists Identify Antibodies That Block Human and Animal SARS Viruses

...utes of Health conducted in vitro experiments on a mouse model to test the neutralizing activity of the antibodies. The researchers say that the new findings are important because animal strains of the virus may be capable of triggering a future human outbreak. "This study is important because the vira...

Stem Cell Treatment may Prolong Lives of Children With Brittle Bone Disease

...holas Fisk of the college, the researchers studied mouse models of human type III osteogenesis imperfecta. ...m cells through the wall of the uterus into 14-day mouse foetuses. It was found that at the age of 3 months, mice treated with stem cells had suffered just...

New Oncogene for Brain Cancer

...logy. Using a gene transfer delivery system in a mouse model, a team led by Zhang and Professor of Pathol... gene, or genes, of interest and injected into the mouse brain. The viral particles infect only glial cells, where the genes are expressed. This system all...

Watch 'Live Earth' Concerts Simultaneously on the Net

... lunt's ballads in London with just a click of the mouse . The website www.LiveEarth.MSN.com will provide netizens with the opportunity to watch the performances of the various stars in real-time simultaneously, a reason why it is being predicted that the event may be a record-breaker. "We expect it ...

Liver Cancer More Prevalent in Males

...Diego (UCSD) School of Medicine have determined in mouse studies. Their discovery that female mice produce far less of the protein called interleukin-6 (IL-6) in response to liver injury than males do, and that production of this protein is suppressed by estrogen, may point the way to therapies to redu...

Parkinsons Disease Mechanism Identified

...he researchers studied the mechanism of PD using a mouse model of the disease, in which a mitochondria-affecting toxin called MPTP is used to produce Parkinsons-like brain pathology. In earlier studies, they had found that MPTP activates protein-snipping enzymes called calpains in mitochondria. They also...

Protein Instrumental to Brain Development and Repair Identified

...s white matter. The groundbreaking discovery in mouse models may lead to inventions for the enhancement of healthy brain development, and improvement in treatments for brain disorders in both children and adults. "By understanding the fundamental mechanisms of brain development, we get closer to find...

Boffins Identify Gene That can Protect Humans from Nephronopthisis

...novative treatment for the disease by working on a mouse model. "Our mice show striking similarities with...stic disease symptoms. It is the first time that a mouse model reveals increased cell death as the mechanism underpinning kidney degeneration in NPHP. The ge...

Specific Protein is Instrumental in Myelination

... white matter. This groundbreaking discovery in mouse models points the way to developing treatments or ...ical Center. Dr. Gallo and colleagues study used mouse models to identify an essential protein and its signaling activity in the processes of myelination a...

New Therapies for Kidney Diseases

...y to save patients suffering from NPHP. With a new mouse model Mathias Treier and his group at EMBL have sh...c disease symptoms. It is the first time that a mouse model reveals increased cell death as the mechanism underpinning kidney degeneration in NPHP. The ge...

Now, 'virtual' Mouse Brains Available on the Net

...ion, three-dimentional microscopic images of tiny mouse brains, which unveil every layer of the organ. ...t http: www.civm.duhs.duke.edu/ show two different mouse brains-one from a normal animal and the other from a rodent missing a gene linked to mental abnormal...

New Cancer Therapy in Clinical Trial

...cer cells in culture and TRAIL-resistant tumors in mouse models. Sorafenib was recently approved by the FDA for treatment of renal cancer and is currently undergoing investigation in over 30 clinical trials for use against a wide range of human cancers, including melanoma, prostate, ovarian, pancreatic, ...

Scientists Identified Obesity Control Switch

...s and causes waistlines to bulge. In some of the mouse experiments, the Dana-Farber investigators inserted PRDM16 genes into precursors of white fat, and implanted the white fat precursors under the skin of the animals. The PRDM16 gene coaxed those cells to generate brown fat cells. "These results illu...

Scientists Identify "master Switch" for Brown Fat in Mice

...alories and causes waistlines to bulge. In some mouse experiments, the researcher inserted PRDM16 genes into precursors of white fat, and implanted the white fat precursors under the skin of the animals. The PRDM16 gene coaxed those cells to generate brown fat cells. "These results illustrate that th...

Researchers Develop First Mouse Model of Lung Transplantation

... of Medicine in St. Louis have developed the first mouse model of lung transplantation , and theyre hoping ...d other solid organ transplants. Ultimately, the mouse model could pave the way for developing new therapies to prevent lung transplant rejection a major ...

Mild Stress During Pregnancy may Worsen Offspring's Risk of Cerebral Palsy

... disability. Though the study was conducted on a mouse model, the researchers from Inserm, l'Institut national de la sante et de la recherche medicale, the French public biomedical research agency, believed that it can apply to humans also. As a part of the study, the boffins adjusted the normal cycle ...

Tumor Blood Flow can Improve Chemotherapy

...mor, Davidoff said. Davidoffs team first treated mouse models that carried transplanted human neuroblasto...h both drugs at the same time. We observed in the mouse model of neuroblastoma that the maximum amount of topotecan reached the tumor and had maximum tumor-...

A New Monoclonal Antibody Kills Cancer Cells

...tumor cell proliferation and survival in human and mouse hepatocellular cancer (HCC) cell lines. Accordin...mpared to later stages of development in the adult mouse liver. They also found significantly higher levels of PDGFR in rat and human liver cancer cell lin...

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