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Tag: "monoclonal" at medical news

Herceptin Use May Enhance Cardiac Toxicity, Study

...h makes the cancer more aggressive. Herceptin is a monoclonal antibody that latches on to these proteins and inhibits tumor growth. Other clinical trials testing Herceptin in combination with chemotherapy have found that between 10-26 percent of patients experienced cardiac toxicity, depending on the treatment ...

Bowel cancer drug plan may not be good for patients

...milar to the breast cancer drug’Herceptin’ and are monoclonal antibodies. Bowel cancer, being the second biggest killer, requires better evaluation of treatment procedures, according to widely held opinion. ...

Catastrophic Elephant Man Drug Trial Victims Injected Recklessly

...g injections at a 'reckless' rate.// The drug, a monoclonal antibody was TGN 1412 that is supposed to fight le... Terry Hamblin, a Southampton University expert on monoclonal antibodies, said: 'When you give an antibody, the quicker you put it in, the more likely you are to ...

Monoclonal Antibody Reduces Exacerbations in Asthmatics

...-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced significantly// fewer diseas... associates infused 14 patients with infliximab, a monoclonal antibody that binds and neutralizes tumor necrosis factor alpha (TNF?). Eighteen patients received p...

Clues to the Mystery of Lou Gehrig's Disease

...k them biochemically." The researchers developed monoclonal antibodies to TDP-43, and tested them in 72 post-mortem tissue samples patients with either ALS or frontotemporal lobar degeneration and found that all 72 cases contained misfolded TDP-43. Dr Lee said, "Since many cases were studied, the data became ...

International Collaboration Takes Aim at Rabies

...ons will collaborate to test and manufacture a new monoclonal antibody (MAB) created by scientists at the MBL, i...from developing the fatal disease. Furthermore, monoclonal antibodies can be produced in large quantities, at much lower costs than blood products and can be s...

Lenalidomide Gives New Hope To Chronic Lymphocytic Leukemia Patients

...sponse to chemotherapy alone, or combined with the monoclonal antibody rituximab, relapse is inevitable and treatment options at that point are limited. Lenalidomide is a novel immune modulating, non-chemotherapy, cancer drug that is chemically similar to thalidomide, but is more potent in the laboratory and...

Researchers Develop Basis For Experimental Melanoma Treatment

...created an infection-fighting antibody, known as a monoclonal antibody that binds to melanin based on scientific...lanomas might contain melanin that would allow the monoclonal antibody to deliver radiation to tumor cells. Dr. Casadevall then teamed with his colleague Ekaterin...

Survival of Mice With Human Breast Cancer Extended by Monoclonal Antibodies

...a study done by Kate Rittenhouse-Olson, Ph.D., the monoclonal antibody developed by researchers at the University at Buffalo has been shown to extend// significantly the survival of mice with human breast-cancer tumors. The study also finds that the antibody inhibits the cancer's spread to the lungs in the an...

'Hen Factories' To Synthesize Cancer Drugs

...ed eggs whose whites contained proteins like the monoclonal antibody, m1r24, used in the treatment of melanoma...duced in bacteria. Many therapeutic proteins, like monoclonal antibodies, are produced commercially in industrial bioreactors. This method is time-consuming, besi...

New Treatment For Psoriasis Is Highly Effective

...i-IL-12 Study Group) showed that a different human monoclonal antibody to p40 was effective in the treatment of ...p determine the most effective dosage of these new monoclonal antibody therapies.' Source-Newswise...

PET Imaging Identifies Aggressive Kidney Cancers That Require Surgery

...n the study, the researchers used the radiolabeled monoclonal antibody G250, which was originally developed as a potential therapeutic agent by study co-author Lloyd J. Old, MD, Director of the New York Branch of the Ludwig Institute for Cancer Research (LICR), and an investigator at MSKCC. G250 has since been ...

Doctors Hopeful for Elizabeth Edwards

...hormone, or chemotherapy. Looking to the future, a monoclonal antibody called denosumab is currently in clinical trials for use against both bone metastasis and osteoporosis, say scientists. While the treatments now available can only delay the progression of the cancer and alleviate symptoms, the tumor may ...

Tumors Targeted Naturally

...r approach employs a cell-binding agent, such as a monoclonal antibody, that is powerfully attracted to the target receptor and holds fast to any cell displaying it. Although this strategy has benefits, it's not natural, says Kiessling. Cell recognition in living systems instead involves binding agents that a...

Crucell's Rabies MAb Enters Phase I Trial in India

Dutch biotechnology company, Crucell N V’s Rabies monoclonal antibody (mAb) product has entered a phase I clini... study in the US. Crucell has developed a human monoclonal antibody product for the post-exposure prophylaxis of rabies, using Crucell’s MAbstract and Crucell’...

A New Erbitux Combo Shows Promise in treatment

...spread to other parts of the body. Erbitux is a monoclonal antibody that targets a protein called the epidermal growth factor receptor (EGFR). EGFR is found at abnormally high levels on the surface of many types of cancer cells. Antibodies are the body’s natural defence mechanism against infection. They a...

Researchers Have Identified Subgroup Sensitive to the Drug Cisplatin

...those tumors are candidates for treatment with the monoclonal antibody Herceptin. The third major subtype is the 15 to 20 percent of breast tumors that have neither estrogen nor progesterone receptors and also do not overexpress HER2. Since these so-called "triple-negative" tumors are treatable with neither H...

Denosumab Reduces Bone Erosion

...ion of bone erosion . Denosumab is a fully human monoclonal antibody which binds to and inhibits the RANK Ligand. The RANK Ligand is the essential mediator of osteoclast formation, function, and survival and thereby plays a key role in rheumatoid arthritis (RA) associated bone erosions (osteoclasts are the ce...

Study Finds Lymphoma Drug Effective Over Long Term

...otherapy, or a combination of chemotherapy and the monoclonal antibody rituximab. These treatments are usually given every three weeks over a span of up to six months and can cause many unpleasant side effects, including nausea, hair loss and infections. Bexxar, whose chemical name is tositumomab and iodine I...

Combination Improves Survival of Metastatic Melanoma Patients: Phase II Study

...ients with metastatic melanoma. Bevacizumab is a monoclonal antibody that binds VEGF and blocks its interaction with cellular receptors. This action prevents new blood vessels from forming and allows the chemotherapy to work. Fifty-three patients were treated with carboplatin, weekly treatments of paclitaxe...

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