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Tag: "molecules" at medical news

A new century of Alzheimer's disease research

...oratory analysis of AB42 showed that the extra two molecules seemed to form a hook on the amyloid protein, maki...olved. As Alzheimer’s develops, the shape of tau molecules inside neurons changes; they begin to come off the microtubules they had once supported, and bind to...

Pure Pomegranate Juice Helps Reverse Erectile Dysfunction Function

... pomegranate juice, which can prevent free radical molecules from disrupting proper circulatory function. 'These findings are very encouraging as they suggest there is a non-invasive, non-drug way to potentially alleviate this quality of life issue that affects so many men. For men with ED, it is important ...

Translating Structure into Function

...ure of an enzyme and then screen many thousands of molecules for one that fits into the empty active site of th...rks well for one kind of drug discovery -- finding molecules to fit in the active site and physically block enzyme action. But the research team sought to divine...

Alternative Splicing in Neuronal Development

...rocessing of an RNA transcript into different mRNA molecules by including some exons and excluding others. Specific cell types often have signature patterns of alternative splicing. Polypyrimidine-tract binding protein (PTB) is a well-known inhibitor of alternative splicing in various cell types. A neuronal ...

Therapeutic Cancer Vaccine Trials

...or, is used to introduce cancer proteins and other molecules to stimulate the immune system. Both approaches are designed to rile the patients immune system into attacking tumor cells. In their review Schlom and his colleagues looked at two cell-based vaccines, Sipuleucel-T (Provenge) and GVAX, as well as th...

Gene Variation Increases the Risk of Lung Cancer

...r interleukin 1A and interleukin 1B, two signaling molecules that immune system cells secrete in response to infection or tissue damage. Our findings help explain how heavy smoking, for example, combines with a genetic predisposition to create a besieged environment within the lungs, said lead author Eric En...

New Antidotes may Harbour Treatments for Deadliest Poisons

...esearchers led by Jose Saenz screened 14,400 small molecules for compounds that could halt this journey without...researchers' work led to the identification of two molecules that may offer treatments for these toxins....

Skin Cancer can Be Triggered by P53 Mutation

...emokine receptor D6 acts to sequester inflammatory molecules known as chemokines and as such is essential to suppressing the development of skin cancer. They show that D6-deficient mice are acutely sensitive to SCC formation and that D6 expression is induced in cells in close proximity to invasive SCC cells ...

Stem Cells Research in Parkinsons Disease

...e brains own self-repair mechanisms by pumping out molecules that boost nerve survival and blood vessel development and decrease neural degeneration. We at the Center for Aging and Brain Repair at USF Health have been arguing, for some time now, that stem cells are important for brain repair because they pro...

Cell Toxin Inhibits Survival Protein in Cancer Cells

...lleagues set up screening assays to look for small molecules or compounds that are selectively toxic to cells that over express Bcl-2 proteins. Higher expression of the target protein made cells more sensitive to the 2-Methoxy antimycin inhibitor. This is called a gain of function mechanism and is counterint...

Protein Interaction is a Drug Target for Blood Clot Prevention

... Platelet aggregation involves the binding of many molecules to platelet integrin alpha-IIb beta 3, and blockade of this binding is effective in the prevention of blood clots. However, chronic use of oral drugs that block alpha-IIb beta 3 activation have not proved beneficial in preventing recurrent blood cl...

Genes Play Major Role in Determining Individual's Sour Taste Perception

...aste system is able to detect and translate acidic molecules on the tongue into a neural signal that the brain perceives as 'sour.' "Demonstrating a genetic component to individual differences in sour taste is the first step in pinpointing the genes that determine sensitivity. The products of those genes, in...

Protein Structure of Pathogens Associated With CF and TB Solved

...ron from the host. To do this, they make complex molecules that bind tightly to the iron. We have determined ... to produce normal amounts of one of these complex molecules in Pseudomonas. What is interesting is that other bacteria use a very similar protein and we assume ...

This is Why DNA Has Its Famous Helix Shape

...s precise measurements of forces within individual molecules down to one pico-Newton--a trillionth of a Newton. For a sense of scale, the force of gravity on a two-liter bottle of soda is about 20 Newtons. "They captured the range of stacking forces by measuring two types of synthetic DNA strands: some made...

Human Membranes Crystal Structure may Help Tailor Asthma Drugs

... of the active sites, where activating or blocking molecules can attach, have been identified. With this knowledge it is now achievable to shape new molecules that can block the LTC4 synthase. The new results are also very important as they can lead the wa...

Nano Propellers may Be Tomorrows Drug Deliverers

...water-attracting -- they become clogged with water molecules and pump poorly, the study showed. "Pumping rates and efficiencies in the hydrophilic and hydrophobic forms can differ by an order of magnitude, which was not expected," said Prof. Kral....

Simple Chemical Reaction may Help Early Disease Diagnosis

...mple chemical reaction might help detect important molecules in blood and urine. The technique is effective ...etabolites, amino acids, by chemically tagging the molecules of interest so that they were more easily visible. "We added a chemical that reacts with the amino...

Alzheimers Disease Enzyme may Interfere With Brain Function

...crease production of the alpha subunits, but those molecules are not incorporated into new sodium channels on the cell surface. The resulting deficit of membrane sodium channels inhibits the passage of neuronal signals into and through the cells. Neuronal sodium-channel dysfunction is known to cause seizures...

Alzheimer's-associated Enzyme Linked to Seizures

...ase the formation of the alpha subunits, but those molecules were not integrated into new sodium channels on the cell surface. The resulting scarcity of membrane sodium channels inhibited the path of neuronal signals into and through the cells. "We have found a molecular pathway by which BACE can modulate th...

Genetic Variations Leads to Fever After Smallpox Vaccination

...gly, studies in mice have shown that immune system molecules produced by the IL-1 and IL-18 genes are linked to tissue damage in viral myocarditis, raising the question of whether a more severe complication of smallpox vaccination might be associated with variations in these genes. Stanley hopes further stud...

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