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Tag: "molecule" at medical news

Targeting PARP1 Is Effective In Protecting HD Cells from Damage

... envision broad therapeutic applications for small molecule inhibitors of PARP1.’ Kazantsev is an assistant professor of Neurology at Harvard Medical School. Souce: Eurekalert...

Muscular Dystrophy Reversed In Lab Mice

...he abnormalities. This therapy targeted a specific molecule and silenced it during the course of the disease. Lead researcher Dr Mani Mahadevan and his team found that toxic mRNA causes the disease and they also found a way to turn it off in mice. "The fact that the course of the disease can be reversed bot...

Role Of MicroRNAs In Angiogenesis Researched

...t" associated with messenger RNA, the intermediary molecule that "instructs" the cell's protein-building machinery. In particular, MicroRNAs help determine the life span of messenger RNA and, therefore, how many copies of a protein can be made from a single messenger RNA molecule. The Penn researchers disco...

Scientist Move A Step Closer To Treating Genetic Obesity

...s lead author. UF researchers have already found a molecule that seems to correct one of the mutations, keepin...I like to focus on is seeing if we can design some molecule or drug that can fix this." Source: Eurekalert...

Marijuana Use Can Compromise Pregnancy

...ons the two receptors are activated by a signaling molecule called anandamide, which is synthesized by an enzyme known as NAPE-PLD and then is degraded by another enzyme called FAAH. This balance, or "tone," of the anandamide is crucial for the embryo to develop normally.When Dey and his team suppressed FAAH ...

Finally, The First Ever Treatment for Drug-Resistant HIV

...ch is possible only due to the creation// of a new molecule by a researcher from Purdue University. The molecu...rug and been approved by the FDA so quickly." The molecule Ghosh created is expected to be available to physicians this year, he said. "I think that this dr...

A Major Break Through in Treatment for Metabolic Syndrome

... interact. They found a flexible tail on the SREBP molecule that fits into a specific groove on a region of AR...tween SREBP and ARC105 might be a target for small molecule drugs, according to Dr. Wagner. "While RNAi completely knocks out a protein including its other fu...

Research Leads to First Treatment for Drug-Resistant HIV

...d tool to treat drug-resistant HIV thanks to a new molecule created by a Purdue University researcher.// "The...ug and been approved by the FDA so quickly." The molecule Ghosh created is expected to be available to physicians this year, he said. "I think that this dru...

Single Sugar Enables Antibody to Treat Inflammation

...terminal sialic acid on the Fc portions of the IgG molecule were the root of the anti-inflammatory activity. When the researchers removed the sialic acid, the molecule retained its structure and its half-life, but it lost its protective abilities. "This is a very inte...

Fat Metabolism Of Heart Muscles Affected By High Blood Pressure

...ohydrates. "Carbohydrates produce less energy per molecule than fatty acids," she says. "With hypertrophy, the heart has a higher energy demand because there's more muscle to feed. With less fat metabolism, a greater reliance on carbohydrates may represent a shift to a less-efficient fuel." The metabolic ab...

Improving Treatment Options for Multiple Sclerosis

...kB. They investigated the effects of blocking this molecule in mice that portrayed MS like symptoms. Pasparakis, a former Group Leader at EMBL's Mouse Biology Unit said, “ We have known for a long time that NF-kB is crucially involved in MS, but until now it was not clear if it was friend or foe.” The fi...

Scientist Discovers Crucial Part of Blood-Clotting Process

...nds that prevents unwanted blood clotting. It is a molecule with many places where enzymes and other substance...ing with antithrombin, a small naturally occurring molecule that inactivates several enzymes involved in the coagulation process. They hope to gain understandin...

Activated T-Cells Could Help In The Battle Against HIV

...iciently control HIV, the researchers focused on a molecule called interleuken-12 (IL-12). When dendritic cells recognize and capture viral antigens, they work together with CD4 T cells to release IL-12, which in turn triggers stimulation of killer CD8 cells that are specific to the virus. Reporting at AIDS...

Treating Depression may Raise Anxiety Levels

...s they claim to have identified a "chameleon" like molecule in the brain that plays contrasting roles dependin...ain located inside the temporal lobe. But the same molecule increased the anxiety levels when present in another region called "amygdala", an almond-shaped stru...

Anthrax may be detected in minutes

... anthrax surface molecule. They then attached this molecule to a special carrier protein and injected it into mice, reported the online edition of BBC News. The mice mounted an immune response to the injection. The scientists were then able to obtain antibodies from the mice that were specific for the anthr...

Monoclonal Antibody based system for Anthrax detection

... These antibodies bound exclusively to the surface molecule of Bacillus anthracis. They did not bind to other bacteria closely related to B. anthracis. Seeberger hoped that a highly sensitive anthrax diagnostic system and new vaccines would be based on this new antibody. "I think it would be very useful and...

Sour Taste Sensors Identified

...ers' attention was drawn immediately to a receptor molecule known as PKD2L1, which is related to a large family of proteins that shuttle ions into and out of cells. As predicted for a candidate sour receptor, PKD2L1 was not found in the cells that express the receptors for sweet, bitter, and umami, but instea...

Elusive Step In DNA Mutation Uncovered By Researchers

... in a series that brings about a change in the DNA molecule – one that evades the body's proof reading mechani...ilable because, formally, it requires that a water molecule (H2O) split apart into a proton (H+) and a hydroxyl anion (OH-). This large energy requirement has p...

Fresh Water Algae Filtered Out With Water Filtration Technique

...oxin used in this study was microcystin-lr, a tiny molecule made up of only seven amino acids. The study will appear in the journal Environmental Science & Technology, and has been published in advance on the journal's Web site. Rather than invent a new technology for filtering microcystin-lr, Walker and ...

A Synthetic Molecule Instigates Cancer Cells To Self-Harm

..., to go on unimpeded, which is to have a synthetic molecule that actually triggers apoptosis. For this, the te...o change procaspase-3 into caspase-3. This potent molecule was termed as PAC -1 PAC-1 was found to be able to obliterate many types of cancer cells, but its...

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