Deciphering the protection agent 0f viruses to help penetrate them
... enters a human cell through the membrane, the RNA molecule that carries its genes is transported into the cen... of the virus that go on to infect more cells. One molecule that is crucial in this process is a viral protein called nucleoprotein. The protein ensures that on...Bioinformatics Made a Boon In Immune Response Study - LIAI Finds
...understanding, which epitopes will bind to the MHC molecule and cause an immune attack, scientists can use those epitopes to develop a vaccine to ward off illness – in this case to smallpox. The scientists were able to find 95 percent of the MHC binding epitopes through the computer modeling. ‘This is the f...A New Marker For Type-2 Diabetes ?
Elevated levels of a molecule called RBP4 (retinol binding protein 4) is an indication of an early stage of the development of insulin resistance //, the main cause of type 2 diabetes, as also cardiovascular disease and metabolic syndrome, according to a recent study. Resear...Advance in Program for Development of Non-Intravenous Therapy for Hemophilia
... of poor distribution or rapid inactivation of the molecule in the body. Therefore, potential non-intravenous therapy must be able to reach its target site quickly and effectively without being inactivated in the process. "We are very pleased by the progress to date in this collaboration with Jerini," said ...Rheumatoid Arthritis Can Manifest In Various Unknown Risks
...king the action of TNF (tumour necrosis factor), a molecule responsible for increasing levels of inflammation in people with rheumatoid arthritis. "The reason why the TNF inhibitors have shown to reduce the risk of MI and CVA could be that the events are caused by inflammatory factors, which is reduced by the...Anti-Glycolytic Therapy Proved to be Effective Against Tumors
...rapies with anti-angiogenic ones. ‘If you have a molecule that is very stable you could think about delivering it first, obliterating the glycolytic pathway,’ said Fantin. Angiogenesis inhibitors would wipe out blood vessels and the oxygen supply with it, leaving the cells with no way to cope. ‘There is def...New discovery may help treat stroke-affected humans
...when their brains were infused for one week with a molecule that stimulates Notch. The rats also sprouted new cells in the brain. The researchers, Nature says, do not yet know whether this could be used to treat humans after a stroke, because stimulating Notch could have many other, perhaps unwanted, effect...Scientist Optimistic In Breakthrough For Causes Of Neurodegenerative Diseases
...yrosine, is in the presence of an oxidative-stress molecule called peroxynitrate. The biomarker was found on 31 sites along 29 different proteins, half of which had been previously implicated in several of the neurodegenerative diseases. "Our study certainly suggests that the sensitivity of certain proteins...Suitable Culturing Medium, essential for Stem Cell Development
...ments, scientists confirmed a cell culture surface molecule called laminin activates a common developmental pa...tive function. ‘This is significant because this molecule is frequently used to secure cells onto culture dishes in stem cell labs all over the world,’ said B...Autoimmune disorders studied in detail by U-M researchers.
... referred to as the cell’s energy currency, is the molecule that captures chemical energy from food and transfers it to energy-demanding processes, such as muscle contraction and the transmission of nerve signals. 'People had proposed in the past that if you could inhibit this enzyme, there might be therape...Bone Marrow Cells Aid In Heart Repair
...ls, plays a central role in this mobilization. The molecule c-kit is the 'switch' that needs to be turned on b...' sent by the damaged heart. By binding to another molecule called the stem cell factor – much like a lock and key -- the "turned on" c-kit activates the bone m......ctivate various other cellular signals including a molecule called STAT3--but the role of STAT3 in mediating leptin's multiple physiological effects was still unknown,’ says Dr. Luciano Rossetti, the study's senior author and the director of the Diabetes Research and Training Center at Einstein. To learn whet...Natural Approach to Immune Regulation May Help Transplant Patients
A molecule expressed during pregnancy seems to turn down the ...the earliest stages of embryo implantation and the molecule goes away toward the end of pregnancy. Growth factors and cytokines – signaling compounds involved i...Aurobindo Gets USFDA Approval for Didanosine Chewable Tablets
...e ARV regimens in various parts of the world. This molecule enjoys approximately USD 100 mio of market share, it said. The drug helps prevent AIDS virus from reproducing. It is used in combination with other antiretroviral agents for the treatment of HIV-1 infection. It is the version of VIDEX an anti-HIV me...New Technique Identifies Unknown Genetic Mutations That Can Cause Cancer
...activation carries a calling card in the form of a molecule called a phosphate. "The phosphates signal activated tyrosine kinases," said Druker. "So we decided to use the phosphates as markers." To find these markers, the team took myeloid leukemia cells and chemically digested them into a mixture of prot...Research Finds That Nicotine Hastens The Growth Of Lung Cancer
...lls closely it was revealed that nicotine caused a molecule called Raf-1 to bind to a key protein called Rb, which normally suppresses tumors. Chellappan explained that this interference with the Rb protein's function could make the cancer spread faster. He further explained that 8 out of 10 tumors that wer...MRIs Show Drug Treatment Slows Brain Deterioration on Road to Alzheimer's Disease
...s who received placebo (no treatment). APOE 4 is a molecule involved in cholesterol metabolism and is a common genetic predisposition to Alzheimer’s disease. All humans have a form of APOE, but APOE 4, which is present in 25 percent of the population, raises the likelihood of amyloid plaques forming in the br...Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
...interferon secretion has been described as the key molecule T cells use to rid the body of Chlamydia." The findings show how T cell responses can be studied in reproductive tissues, which is likely to reveal avenues to the development of vaccines against Chlamydia, and possibly other STDs. "In this report...Lupin Gets DCGI Nod For Phase II Clinical Trials On Desoside-P
...(DCGI) to conduct Phase II clinical trials for the molecule LL-42 18 (Desoside-P).// The company received pe... after DCGI found the clinical Phase I data of the molecule to be satisfactory. Lupin informed the Bombay Stock Exchange that it intends to begin clinical tria...... that treatment with an 'iron chelater' which is a molecule that can attach to metal ions and neutralize their harmful effects on the body can reduce cell proliferation in the lesions. Research leader Jacques Donnez, head of the department of gynecology at the Catholic University of Louvain 'Our findings re...