Biocon To Shift Focus On Innovation To Accelerate Growth
...ara thyroid hormone (PTH) and Apaza, an oral small molecule for inflammatory bowel diseases," Shaw pointed out. As part of its long-term strategy, the company plans to build bio-similar therapeutic protein franchise through in-house development and strategic collaborations. With the commissioning of the m...A new medicine source: wallaby milk
...the milk of the female tammar wallabies contains a molecule //that is 100 times more effective against bacteri...they just rely on milk". He further added that the molecule in the wallaby milk, called AGG01, is effective against a range of bacteria and one type of fungus. ...Cholesterol Plays An Important Role In Finger and Toe Development
...g concentration of the protein. That a cholesterol molecule had to be attached to the protein, for it to work ...edgehog protein. This ensured that the cholesterol molecule would remain free, as it cannot attach itself to the modified protein. As expected, mice with the ...A Detail Analysis of Head and Neck Cancer
...luronan (HA), and LARG. CD44 is a surface receptor molecule that plays an important role in a variety of cellular functions. Hyaluronan (HA) is a complex carbohydrate found in the connective tissues between cells. LARG is a signal activator found in tumor cells. The triple interaction results in the initiatio...Immunization at Birth Envisaged
...mmune response in newborns, with a certain type of molecule present at birth. The discovery of this molecule has been made lately. This study has been published in the Journal Blood, which is optimistic of b......n detected in SOD1. The normal form of SOD1 is a molecule composed of two identical parts, each with an amin...lecular disulfide linkage -- a bond within an SOD1 molecule that stabilizes the structure. Intermolecular disulfide bonds, or cross-links, are incorrect bonds t...A protein in the brain paves way for Alzheimer's treatment
...ay. The crucial point is now to discover a small molecule that resembles and functions in the same way as this protein. Abeta-blocking compound would likely be used in conjunction with other therapies, such as a promising new Alzheimer's vaccine. Alzheimer's drug therapy would also require ongoing doses ove...Cancer Research UK Offers New Hope To Cancer Patients
..., the company will be given the option to take the molecule back and develop it themselves, or to leave it in the hands of the CRT scientists. Harpal Kumar CRT chief executive hopes that the scheme that would cost up to £2 million a year, will help to identify at least five more drug molecules annually, to...Insulin Crystals Holds Promise In Diabetes research
...is the reason for these crystals. After an insulin molecule is produced from proinsulin, it attaches to an insulin crystal only in special locations where other insulin molecules have formed right angles, called kinks. Using atomic-force microscopy, they discovered a new mechanism by which insulin molecules a...Nanotechnology Could Revolutionize Cardiac Treatment
...a structure known as a micelle. Uhrich synthesized molecule chains with several different characteristics, such as attracting or repelling water or having a positive or negative charge. When the chains assembled into micelles, Mogue tested them for how well they blocked LDL uptake. ‘We're employing the tool...Link Between Immune System And Nervous System
...e RANTES, to increase the calcium flow. The RANTES molecule is important because it binds to another cell receptor, CCR5, which is crucial in allowing common strains of HIV (R5 strains) to infect immune cells. Significantly, when the investigators added the drug aprepitant, which binds to NK-1R, to their ce...Discovery Of New Molecule Could Solve Cancer Spread Mystery
...er Cell says that scientists have identified a new molecule that could resolve the mystery of how cancer progresses.// This molecule was found to inhibit the progression of lethal malignant glioma cells both in vivo as well as in vit...Researchers Develop Potent Cancer Killer From Vitamin E Derivative
...xL protein, disabling it. However, the vitamin E molecule has a long, coiled, protruding tail that keeps the molecule from fitting tightly, and more effectively, into the groove. ‘Once we identified how the agent and...New Research May Be Useful for Developing Drugs for HIV and Cancer
...n interacts with platinum, the zinc portion of the molecule is ejected from the protein chain. This causes the protein to lose its tertiary structure or overall shape. For these molecules, shape is an important property that enables the protein to carry out certain biological functions. The process, active ...Study Highlights How Bacteria Respond To Changes In Environment
...a lot of different things. But assume it's a sugar molecule that a bacterium needs as a nutrient -- even a 0.1...eceptor array amplifies the signal that a specific molecule has been sensed outside the cell. This structural shift then activates kinases, or enzymes, within t......desirable side effects. ‘If you could find a small molecule that would flip 10 percent of the existing NFATc into the active form,’ Crabtree said, ‘you could favor the formation of osteoblasts and make stronger bones.’ (Surce: Eurekalert)...Cancer-Causing Virus Synthesizes Protein To Help Sustain Itself In Host Cells
... in only a few retroviruses, including HIV. A DNA molecule is somewhat like a railroad track that is twisted into a double helix. The two rails correspond to the complementary strands of the DNA backbone, while the ties correspond to the chemical base pairs that hold the two strands together and encode genet...Restriction of Carbohydrates to Prevent Alzheimer's Disease
... caloric restriction through promotion of SIRT1 (a molecule associated with brain longevity) may initiate a cascade of events like the activation of alpha-secretase which can prevent AD amyloid neuropathology. Since alpha-secretase is known also to inhibit the generation of beta-amyloid peptides in the AD aff...Growth Factor Aids in Regeneration of Heart Blood Vessel
...e in St. Louis have investigated a third signaling molecule -- called Sonic hedgehog -- that could overcome problems associated with FGF2 and VEGF therapy. In a report appearing in the June 15 issue of Genes and Development, the team showed that activating hedgehog signals in adult mouse hearts led to an in...Growth Factors Help Neurons to Reach Their Correct Destination
...hat we finally nailed the growth factor FGF as the molecule that guides a specific subgroup of motor neurons to connect to the muscles that line our spine and neck,’ says senior author Samuel Pfaff, Ph.D., a professor in the Gene Expression Laboratory, ‘but that piece by piece, we are uncovering general princ...