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Tag: "molecular" at medical news

A new century of Alzheimer's disease research

...e microtubules, which in turn cannot transport the molecular cargo needed to keep the neuron alive. “Either t...dn’t remember any of its tasks -- when we hit this molecular switch, the mouse recovered a lot of its memory.” To the research team, this demonstrated that Alzh...

Translating Structure into Function

...teams success came by modifying a technique called molecular docking, a computer-aided modeling strategy used to search for potential drugs. Docking works by allowing researchers to first determine the atom-by-atom structure of an enzyme and then screen many thousands of molecules for one that fits into the em...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

...arian tumours had the AKT1 mutation. "Recently, molecular features such as the AKT1 mutation are beginning t...is discovery adds to the short but growing list of molecular features that may help guide both current and future cancer drug development," said Dr. John Carpten...

New Oncogene for Brain Cancer

...med, suggesting that the two genes lie in the same molecular pathway and have a similar effect. For oligodendroglioma, the researchers found that IGFBP2 combined with platelet-derived growth factor beta (PDGFB) results in a higher-grade form of the cancer than that caused by PDGFB alone. The high-grade tumor...

Insight Into Neural Stem Cells Has Implications For Designing Therapies

...ays Merkle, is a key step toward understanding the molecular mechanisms of neural stem cell potential. "Now you could compare adult stem cells in different regions at the genetic level. Since different neural stem cells make different types of neurons, maybe you could determine which genes are important for ma...

New Asthma Gene Identified

...erapies because it points to a specific biological molecular pathway. Once we understand the biology and we know the players, it's possible to target with specific drugs." Childhood asthma treatments are heavily focused on allergic responses, since most children with asthma also have many allergies. The disco...

Fibrinogen may Inhibit Spinal Cord Regeneration

... repair themselves. The findings, which show the molecular link between vascular and neuronal damage during injury to the central nervous system, was published in the online issue of the Proceedings of the National Academy of Sciences on July 2. The research team studied three types of spinal cord injuries ...

NanoSensors Provides Update on Its Biosensor to Detect E.coli and Salmonella

...ng and selling systems for testing in the clinical molecular diagnostics, industrial and bio-threat markets. "We have decided to explore these alternatives due to our limited personnel and financial resources," stated Dr. Ted Wong, the Company's Chief Executive Officer. "While we will continue to explore mea...

Nanospectrometer Aids in Identifying Nutrient Cycle

...n-cancerous cells. Gunther Dennert, professor of molecular microbiology at the USC Keck School of Medicine, said he could see many interesting questions, which could perhaps be attacked experimentally by this technique. For example, how do tissues react upon implantation of a metastasizing tumor cell, and ...

Experts Propose New Criteria for Alzheimer's Diagnosis

...rs of AD are now available through structural MRI, molecular neuroimaging with PET, and cerebrospinal fluid analyses," says Dr. Bruno Dubois, Salpetriere Hosptial, Paris, France. According to experts, the new criteria for probable AD requires that patients show progressive memory loss over more than six mon...

Afro- American Women Have More Aggressive Breast Cancer

...ferson Medical College. They compared clinical, molecular and demographic data from 2,230 African American a...casian women to try to sort out differences at the molecular level. The study is published online in July 9, 2007 issue of the journal Cancer....

New Therapies for Kidney Diseases

...r and his group at EMBL have shed new light on the molecular mechanisms underlying NPHP opening up novel ways to treat the disease. Our mice show striking similarities with NPHP patients, says Mathias Treier, group leader at EMBL. Very early on in their lives their kidney cells start to die and the mice deve...

Insights into Acute Promyelocytic Leukemia

... provide key mechanistic insights into the complex molecular events that cause a deadly type of leukemia.APL is a cancer of the bone marrow that occurs when certain developing white blood cells get stuck at a highly proliferative and immature stage. The abnormal cells accumulate and eventually crowd out the no...

Gallstone Gene Discovered by Research Team

...ticular gene has the directions for constructing a molecular pump which carries cholesterol from the liver into the bile ducts. It is from this cholesterol that gallstones are produced. This modification of the gene results in the pump working enduringly at high speed. The occurrence of gallstone is quite comm...

Milk Thistle Extract Effective in Cancer Treatment

...ting the safety and efficacy of milk thistle. The molecular makeup of silymarin. Benefits of silymarin use before and during toxic insults to the liver, including damage from alcohol; cancer chemotherapy and other drugs; solvents; and mushroom poisoning. Direction for future research on milk thistle for ca...

Researchers Develop First Mouse Model of Lung Transplantation

...is so critical. It will allow us to understand the molecular mechanisms that control lung transplant rejection, he added. Lung transplants are the only treatment option for end-stage lung disease, including chronic obstructive pulmonary disease (COPD), cystic fibrosis, pulmonary fibrosis and certain congenit...

Kaposi Sarcoma Arise from Multiple Cells

...rom 98 Kaposi sarcoma patients were analyzed using molecular diagnostic techniques to compare the viral DNA of the tumors, which often contain human herpesvirus 8. The researchers found evidence that nearly 80% of the tumors arose independently from multiple cells. They concluded that few Kaposi sarcoma tumor...

Cell Toxin Inhibits Survival Protein in Cancer Cells

...on with other agents, and could lead to a targeted molecular therapy to enhance the effectiveness of cancer treatments. Hockenbery said his groups approach illustrated the need to look at how the proteins interact with everything else in the cell. By over expressing this protein, the cell is changed in some in...

New Understanding on Growth of Human Stem Cells

...roote. The institute has a research focus on the molecular determinants of cancer and tissue repair and is building scientific momentum. This discovery of a new fundamental understanding about how human stem cells develop is the kind of scientific work which has already put this Institute on the map as the...

A New Monoclonal Antibody Kills Cancer Cells

....D., associate professor, division of cellular and molecular pathology and colleagues at the University of Pittsburgh School of Medicine, obtained rat and human liver cancer cell lines and analyzed them for level of expression of an RTK protein known as platelet-derived growth factor receptor-alpha.The investi...

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