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Tag: "microenvironment" at medical news

Gene Variation Increases the Risk of Lung Cancer

...cs. Essentially, sustained inflammation alters the microenvironment of the lung tissue, damaging cells and altering DNA. Inflammation is part of the immune systems arsenal to combat the effects of infection and cell damage. However, prolonged or intense inflammation could lead to conditions within the lung environm...

New Technique Dissects Stem Cells' Picky Likes, Dislikes

... stem cells nestle within the "stem cell niche," a microenvironment in which they bump against the surfaces of other cells, as well as adhere to a substrate called the extracellular matrix (ECM). These interactions with surfaces play a key role in stem cell growth and differentiation. And that got Kiessling thinking....

Developing Antimetastasis Therapy- An Early Stage of Tumor Control.

...ered a tissue culture model of the tumor-lymphatic microenvironment and developed computational models to calculate the gradients of the signaling molecule. The study provides the first evidence that tumor cells can both produce and use the same signaling molecule, and it highlights the significance of the biophys...

Neural Stem Cells Reduce Parkinsons Symptoms in Monkeys

... progeny containing these markers suggest that the microenvironment within and around the brain lesions still permits development of a dopamine phenotype by responsive progenitor cells. The stem cells also made a growth factor that has been shown to improve dopamine function. The neural stem cells are derived from ...

A New Strategy to Control Breast Cancer

...re. Tumor cells, says Bissell, exist in the same microenvironment as healthy cells and must therefore appropriate normal physiological processes to facilitate their growth and spread. This idea can open up potential new avenues and targets for diagnostic and therapeutic applications. “Because of this, we turned ...

MIT Creates 3-D Scaffold for Growing Stem Cells

...w synthetic structure can provide a more conducive microenvironment for tissue cell cultures and tissues used in regenerative medicine, such as skin grafts or neurons to replace brain cells lost to injury or disease. The scaffold itself can be transplanted directly into the body with no ill effects. "The time has...

Innovative Movies Show Real-Time Immune-Cell Activity within Tumors

...ation and engagement directly within the intricate microenvironment of tumors.” The scientists used a leading-edge i...of the individual cellular components of the tumor microenvironment in real-time. Second, we have demonstrated that T cells physically interact with tumor cells, which ...

Adult stem cells are sensitive to responses from the environment

...the Penn researchers have proven that the physical microenvironment is also crucial for guiding the cells through diff... their chemical environment." But, the physical microenvironment can change due to injury and also in disease, which would make it difficult to use these stem cells ...

New Model for understanding Tumor Metastasis

...e surrounding normal skin cells in the presence of microenvironment of tumor cells. // The process of metastasis sprea... new insights into the influence of the tumor cell microenvironment on the transformation of normal skin cells, as well as on genetic triggering mechanisms and signalin...

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