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Tag: "metabolite" at medical news

Tamoxifen does not adversely affect the brain

...e spectroscopy to determine levels of the cerebral metabolite myo-inositol, which has been found at elevated lev...ongest period of time had the lowest levels of the metabolite present in their brains. The researchers concluded that both tamoxifen and oestrogen may have neuro...

Bioengineering production strains - Microbia develops new methods

...to engineer the microbial circuitry that regulates metabolite production. He added that the scientists had illus...gh cholesterol. By integrating transcriptional and metabolite data, the authors elucidated the key genetic components and critical regulatory nodes affecting lova...

Teenagers Using Hormones And Dietary Supplements To Good Physique

...ys, included creatine, amino acids, the amino-acid metabolite HMB, the hormone dehydroepiandrosterone (DHEA), growth hormone, and anabolic steroids. Anabolic steroids have the most serious health effects, including testicular atrophy, impotence, liver and kidney damage, an increased risk for heart disease, an...

The 'bitter' proteins

...), said the team. They also found that Abeta – a metabolite of the Alzheimer’s protein hAPP – increased the build-up of hSYN in brain cells. This, said the researchers, shows a possible mechanism for the synergistic effects of one of the proteins on the other.The scientists suggest the interaction between the...

Mushrooms can help fight chronic disease

...veloping chronic diseases. Ergothioneine, a unique metabolite produced by fungi, has been shown to have strong antioxidant properties and to provide cellular protection within the human body. Joy Dubost, doctoral candidate in food science and other Pennsylvania state food scientists have found that among the m...

Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway

The Mycotoxin citrinin (CTN) is a secondary metabolite produced by several fungal species that belong mainly to the genus Penicillium and Monascus. It is widely considered as a hazard contaminant of foods// and feeds, including corn, wheat, rice, barley and nuts, and is known to be cytotoxic and genotoxi...

Prostate Cancer Preventable By Vitamin D Analogs

...ds its being preventable . Calcitriol, an active metabolite of vitamin D and other vitamin D analogs, may help prevent prostate cancer, according to a study presented Nov. 1,// at the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore. The stud...

Tamoxifen Ineffective In Presence Of Genetic Variation in Breast Cancer

...YP2D6 is responsible for activating tamoxifen to a metabolite called endoxifen that is nearly 100 times more potent as an anti-estrogen than tamoxifen itself,” said lead researcher Dr Rae. 'Our study suggests that women who inherit a genetic variant in the CYP2D6 gene appear to be at higher risk of relapse when...

Cancer Causing Chemicals Found In Urine Of Babies Whose Parents Smoke

...udy demonstrated substantial uptake of NNK and its metabolite NNAL in infants exposed to environmental tobacco smoke. "These findings support the concept that persistent exposure to environmental tobacco smoke in childhood could be related to cancer later in life," he said. SOURCE: Eurekalert.com...

Bladder Pain Suppressed By Marijuana-Derived Drug

...imal models//. The synthetic drug is a analog of a metabolite of THC, the principal component of marijuana. The results of the new study presented at the annual meeting of the American Urological Association highlights that the drug can be used in the treatment of hypersensitive bladder disorders and similar ur...

Alzheimer's Drug can be Used to Treat Nerve Agent and Pesticide Poisoning

...repeated the experiments with paraoxon, the active metabolite of the insecticide parathion, and again, all of the animals survived with no signs of toxicity. Because it is difficult to predict when a person might be exposed to toxic levels of nerve agents on the battlefield or in a terrorist attack, or to tox...

New Approach to Early Detection of Ovarian Cancer

...l use the same approach to hone in on the specific metabolite (or metabolites) responsible for differences between healthy women and cancer patients, and make early diagnosis of ovarian cancer possible. These metabolites also could be targets for therapy. Scientists believe that this NMR-based metabonomics ap...

An abused child may grow up to be an abusive parent

...amples of their cerebrospinal fluid to measure the metabolite concentrations of brain neurotransmitters such as serotonin every six months. They followed the infants until they became mothers themselves and studied their maternal behavior to note any abusive behaviors toward their infants. The team found that...

Ramifications of Widespread Use of Tamiflu

...ting the flu. However, Tamiflu’s active agent, the metabolite oseltamivir carboxylate (OC) would be excreted into sewers for several weeks during a pandemic and is expected to withstand biodegradation. According to the researchers in the current study, once birds drink OC-laced water from catchments receiving t...

The Latest Gen About the Human Genome

...e in our DNA can lead to a 100,000-times change in metabolite levels." Basically metabolites are molecules which play a role in the processes that constitute the metabolism in a living being. When all the metabolic reactions form a network it is called a metabolome. "Most medical tests today are based on me...

Drink, Binge and the Genetic Link

...s attributed to an elevated level of aldehyde , a metabolite of alcohol. Aldehyde imparted an unusual color and warmth to the skin, besides causing palpitations and general weakness. The enzyme responsible for alcohol metabolism was Aldehyde Dehydrogenase and ALDH1 was discovered to be the underlying gen...

Now Fingerprints can Be Used to Detect Drugs and Diseases Instead of Blood Samples

..., they designed their system to detect cotinine, a metabolite formed by the body after consumption of nicotine. The researchers wet the fingerprints with a solution containing gold nanoparticles to which cotinine-specific antibodies were attached. These bind to the cotinine. Subsequently, a second antibody, ...

Intake of Polyphenol Speeds Up Fatty Acid Catabolism

...le also did this, but an important human quercetin metabolite had the opposite effect. Therefore in intestinal c...nts with fat cells, both quercetin and a quercetin metabolite were found to change the glucose use in the fat cell. Boer concluded that a change in the energy r...

Anti-doping Rules Must Avoid Unsatisfactory Decisions: WADA

...f were found positive of taking Norandrosterone, a metabolite of nandralone....

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