Tag: "leukemic" at medical news
Therapy Boosts Chemotherapy Effects
...me. The investigators conclude, "Sensitization of leukemic
cells with growth factors is a clinically applicable means of enhancing the efficacy of chemotherapy in patients with AML."...
Chronic Myelogenous Leukemia (CML) Has An Answer Now!
...e US. In the study, Perrotti and his team treated leukemic
mice with forskolin and then discontinued the treatment for a couple of weeks. After resuming the treatment, they observed that forskolin blocked Bcr-Abl activity and reinstated normal cell functioning in the mice that received forskolin, while other...
Blood camp held in Alaska to save leukemic patients
...ope and love which is what is very important for a leukemic
patient to keep going. She says that one should not lose hope. The sponsors for this Iditarod are the Blood Bank of Alaska and General Communication Inc. which is an Anchorage-based company. They are helping both Butcher (51 years old white) and Mi...
Acute Lymphoblastic Leukemia May Attain a 90% Cure Rate
...and elsewhere in identifying specific mutations in leukemic
cells that strongly suggest the likelihood that tr...al disease (MRD), that is the small populations of leukemic
cells that survive initial treatment (induction therapy). These cells can replenish the population o...
Inexpensive ALL Follow-Up Test Developed By St. Jude Researchers
...al disease (MRD), the relatively low percentage of leukemic
cells, which survive following remission induction...ction therapy. The test determined the presence of leukemic
cells, in more than half of the patients (211, 55.5%) even if the cancer cells made up 0.01% or more...
Mouse Models To Determine The Cause Of Aggressive Leukemia
...f both Arf genes resulted in the multiplication of leukemic
cells. These cells later did not respond to the dr...h-promoting factors produced in the mice. When the leukemic
cells from mice that had failed imatinib therapy were removed JAK kinases, which inhibits enzymes re...
New Molecular Treatment Identified To Treat Blood Cell Cancers
...e high affinity, stability and specificity towards leukemic
and lymphoma cells. Hence researchers say that this discovery can be used to image tumors and deliver anti-cancer drugs. The study results were published in the journal Nature Chemical Biology. ‘We believe that this peptide has great potential for ...
A New Anti-Cancer Drug Keeps Resistance Out
...e intolerance and complications of chronic myeloid leukemic
patients - studies published in NEJM finds. In the phase I clinical trials dasatinib overcome Gleevec resistance in about 68 of 84 patients studied - study leader, HHMI investigator Charles L. Sawyers, and colleagues at UCLA's Jonsson Comprehensive...
Discovery In "Bubble Boy" Disease Gene Therapy
...ukemia, the researchers reported. The team removed leukemic
cells from mice that developed cancer and found that gamma C genes had inserted themselves into a variety of oncogenes. In another experiment, the St. Jude investigators used mouse models that lacked Arf but had normal gamma C genes and therefore ...
Mouse Gene With Gene Stutter Will Help Leukemia Research
...the partial tandem duplication occurs early in the leukemic
process and that additional mutations are needed for the disease to occur,” Dorrance says. “That’s what we’re now focused on.” “Ultimately,” Caligiuri says, “we believe that this mouse will further our understanding of how leukemia develops and ope...
Three Molecular Triggers Threaten Leukemia Patients
...of three components, one from each pathway, in the leukemic
blasts found in newly diagnosed patients. Activation of each component - PKCa, pERK2 and pAKT - had an adverse effect on the patient's prospects that was independent of other traditional prognostic factors. Their cumulative impact was greater than si...
Partial-match cell transplants for kids with resistant leukemia
...s that donor immune cells are likely to attack the leukemic
cells remaining in the recipient, a reaction called a graft-versus-tumor response, according to the researchers. During a 12-month follow-up after transplantation, the St. Jude team compared the results of its modified transplantation technique wit...
Cancer Stem Cells Alone spread Cancer
...lls in brain tumors are resistant to radiation and leukemic
stem cells seem to be resistant to chemotherapy.” To understand the molecular program of colon cancer stem cells seems to be their next step and also to find out if the cells have properties that make them resistant to chemotherapy. They hope to ...
New Strategy for the Treatment of CML
...tentiates the activity of dasatinib may reduce the leukemic
burden further, and thereby reduce, or possibly even prevent the emergence of drug resistance. If validated, this concept could have significant implications for the treatment of CML and possibly other hematologic malignancies,” said Grant. This wo...
Leukemia Drug Turns Mini-Molecules Up, Cancer Genes Down
...small molecules called microRNAs (miRNAs) in the// leukemic
cells. The study also shows that three of these miRNAs inhibit the action of two genes important for cancer development, helping to explain how the drug works. The drug is called all-trans-retinoic acid (ATRA) and it is considered the gold stan...
Major Gene Study Uncovers Secrets of Leukemia
...ese mutations reduced the level of PAX5 protein in leukemic
cells or resulted in the formation of PAX5 protein...s to differentiate into B lymphocytes. In ALL, the leukemic
cells fail to differentiate normally and instead remain blocked at an immature stage of development....