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Tag: "knockout" at medical news

Liver Cancer More Prevalent in Males

... IL-6 than the males. Comparing the normal mice to knockout mice missing the IL-6 cytokine, the scientists found that when knockout mice were given DEN, both males and females developed liver cancer at the same, lower, rates. By ...

Sensible Diet, Exercise and Weight Control Increases Longevity

...e blood, said White. However, both sets of Irs2 knockout mice exhibited other characteristics that marked them as healthier. They were more active as they aged, and their glucose metabolism resembled that of younger mice. The researchers also found that after eating, their brains showed higher levels of...

Genome Annotation by Mutation

... genes more easily and inexpensively than existing knockout techniques, Wu says....

Enriching Environment Stimulates Neurons: Hope For Fragile X Syndrome

...ther researchers had shown that exposing Fragile X knockout mice to a stimulating environment ameliorated beha...lder and colleagues tested whether exposure of the knockout mice to an enriched environment caused higher stimulation that would restore normal neuronal plastic...

Brain Cells Activity: New Treatment Target for Psychiatric Diseases

...to study disease processes in a neuregulin-1/ErbB4 knockout mouse and learn more about how neuregulin-1 mediates GABA release. Another key unknown is what regulates neuregulin-1....

Menthol Receptor-A Thermosensitivity Determinant in Cold Temperature

...ponsible for detecting cold, Jordt said. The TRPM8 knockout mice sensed temperatures below 15 C degrees, which indicates the possible existence of another pathway for detecting extreme cold....

Mouse Study Suggests Anxiety Disorders Take Root in Infancy

...mbia University, first created a line of so-called knockout mice that lacked the gene encoding the receptor pr...critical in that regard, the team then crossed the knockout mice with a line engineered to activate receptor expression in particular brain regions. The resulti...

A Protein in Brain Cells Controls Obesity: Research

...n that mice that lack the gene for SH2B1 -- called knockout mice -- become obese, diabetic, and unable to stop...pletely corrected the metabolic disorders that the knockout mice had developed, but also improved the brain cells’ ability to respond to leptin signals and prod...

How Blood Flow Dictates Gene Expression

... loss of vessel tone as the primary defect in Klf2 knockout mice. Now that Klf2 has been established as an important regulator of blood flow in live animals and is required for the development of a healthy cardiovascular system, the next step is to elucidate the role of Klf2 in normal adult blood vessels and ...

Alternative Splicing - Molecular Cloning

...Nova RNA targets and the results were validated in knockout mice that were missing Nova. In the new study, Darnell, with co-first authors Jernej Ule and Giovanni Stefani, took these 50 RNA transcripts and searched them for clusters of sequences they had previously identified as Nova binding sites through b...

Protein Increase Decreases Risk of Heart Failure

...levels of the gene for and the protein S100A1, and knockout mice that lacked S100A1 altogether. S100A1, part of a larger family of proteins called S100, is primarily found at high levels in muscle, particularly the heart. Previous studies by other researchers showed that the protein was reduced by as much a...

Football Fans Warned

...otball matches. The game with Ecuador is the first knockout match and could end with penalties. Tony Urwin of BUPA said: "When people's emotions run high stress levels can shoot up affecting both their heart rate and blood pressure.We are hoping that history does not repeat itself”. "If England gets knoc...

Autoimmune Diseases – Newer Preventive Measure

... cells in a mouse missing the Aire gene. That Aire knockout is a good model for humans with APS1. They found significantly fewer iNKT cells in the thymus, spleen, liver and bone marrow and severely impaired maturation of those cells in mice missing the Aire gene. And the mice given alpha-GalCer had signific...

Research Throws Light On Regeneration of Hearing Cells

...rth – the researchers found more hair cells in the knockout mice than in the ears of normal mice at the same stage of development. The additional cells looked and functioned like normal hair cells and appeared to be actively regenerating. For this follow-up study, the researchers developed a new strain of i...

Little Known DNA Repair Enzyme May Be A Tumor Suppressor Gene

...-signaling molecule. After matings between the p53 knockout mice and Rev3L knockout mice, the investigators isolated and cultured MEFs from all the offspring of the matings to see if a...

More Lizards, Including Pets, Found Venomous

...d author of the research, the venom is the perfect knockout punch by monitor lizards to their prey like small mammals and lizards. It stops blood clotting, rapidly drops blood pressure and heightens the feeling of bite pain. They assume that lizard venom may have gone unnoticed for so long because it is not...

A Novel Method For Measuring Interstitial Fluid Pressure In Cancer Tissues

...uthors compared IFP in skin melanoma grafts in NG2 knockout and wild-type mice. Knocking out NG2 proteoglycan on vasculogenic and angiogenic pericytes was found to reduce interstitial fluid pressure in melanoma. This study also demonstrates that IFP is elevated in skin melanoma. The simplified IFP measureme...

Breakthrough in Type II Diabetes

...ool, who devised the "Akt2 knock out mice". In the knockout mice, they discovered a partial defect in insulin-... Further studies showed that the liver of the Akt2 knockout mice did not respond to insulin by lowering glucose production, and their tissues were consuming les...

Xenotransplantation “breakthrough”

...h Transplantation Society, said, “Alpha galactosyl knockout pigs have been made before, what's new is that [PPL have] cloned them, which makes [production] easier.” He said, “Of concern is the potential risk of transmission of porcine viruses,” but added, “We would welcome any breakthrough that supports the s...

Limiting sperm motility for contraception

... Nature article, who found that the sperm from the knockout mice were less motile and showed less directed movement than normal sperm.To find out whether the sperm from the CatSper-knockout mice could still fertilize eggs, the researchers mixed the sperm with eggs whose outer covering, called the zona pelluci...

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