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Tag: "kinase" at medical news

Structure of TB Enzyme Points the Way to New Drugs: Study

...he Swiss team first identified the enzyme, protein kinase G (PknG), as a promising drug target back in 2004. At the time, they said that the protein is the secret weapon that enables the TB bug, Mycobacterium tuberculosis, to avoid being hunted down and destroyed by the body's immune system sentinels as m...

Combination of Tratuzumab and Chemotherapy Yields Better Results for Breast Cancer

...dy that directly targets part of the HER2 tyrosine kinase receptor. The results showed that combining trastuzumab with chemotherapy results in a -34% reduction in mortality and a 38% increase in disease-free survival, Dahabreh said. Those survival benefits were accompanied by decreases in the risk of both...

Study Confirms Benefits of Chemo, Trastuzumab Combo to Battle Breast Cancer

...dy that directly targets part of the HER2 tyrosine kinase receptor. The results showed that combining trastuzumab with chemotherapy results in a 34 percent reduction in mortality and a 38 percent increase in disease-free survival, Dahabreh said. Those survival benefits were accompanied by decreases in ...

Insulin Sensitizer- Energy Conserving Signal to Brain

...of a metabolic enzyme called AMP-activated protein kinase (AMPK) to stimulate greater food consumption. Moreover, the researchers found that adiponectin decreased energy expenditure. They also showed that blood and spinal fluid adiponectin levels in the brain normally increase during fasting and decrease ...

A New Monoclonal Antibody Kills Cancer Cells

...ment, particularly the class III receptor tyrosine kinase (RTK) family pathway, became highly active again in the liver of HCC patients, Satdarshan P. Singh Monga, M.D., associate professor, division of cellular and molecular pathology and colleagues at the University of Pittsburgh School of Medicine, obtai...

Monoclonal Antibody Induces Death in Liver Cancer Cells

...r the levels of expression of an receptor tyrosine kinase (RTK) protein, shown to be highly active in the liver of HCC patients in some previous studies, known as platelet-derived growth factor receptor-alpha (PDGFRa). The researchers also analysed the cells for their level of activation of the PDGFRa ge...

First Drug for Post-traumatic Stress Disorder

...ve Sciences, and colleagues show that inhibiting a kinase (kinases are enzymes that change proteins) called ...nents of a molecular pathway involving the protein kinase Cdk5," said Tsai, a Howard Hughes Medical Institute investigator. "We found that Cdk5 activity pr...

The Bottleneck in Neuroblastoma

... that cut off a tumor's blood supply, and tyrosine kinase inhibitors that interrupt a critical step in the tumors growth process. These approaches are targeted therapies--aimed in highly selective ways at cancer cells, but sparing healthy cells, said Maris. But in order to best guide us to the most approp...

Research Shows Way for Drug Therapy for Autism

...specific enzyme in the brain, called p21-activated kinase (PAK), as a potential target for drugs that may reverse many of the debilitating symptoms of FXS, and possibly autism, in children. "The enzyme PAK affects the number, size and shape of connections between neurons in the brain," he said. In the b...

Scientists Identify New Possible 'biomarker' for Pancreatic Cancer

...tz, the study found that the RON receptor tyrosine kinase was "over-expressed" in pancreatic cancer cells, suggesting that the receptor may also contribute to the disease's development. The researchers say that their findings, published in the journal Cancer Research, may help scientists better understan...

Insulin Therapy Shown to Treat Early Experimental Diabetic Retinopathy

... on the retina were analyzed using immunoblotting, kinase assays and immunohistochemical analysis. Additionally, insulin-loaded hydrogels were designed for subconjunctival implantation to provide low levels of insulin to the retina for prolonged periods. The hydrogels were engineered to be thermoresponsive ...

Study Implicates Protein as a Trigger of Advanced Prostate Cancer Recurrence

...e protein, named Ack1, is a member of the tyrosine kinase gene family. Ack1 exerts its effect on the reemerg...pharmacology, and other Lineberger scientists. The kinase activates the receptor via phosphorylation by adding a phosphate group to this protein molecule. ...

Americans Optimistic About the War on Cancer

...eness of common cancer therapies, a multi-targeted kinase inhibitor (ABT-869) being investigated to suppress tumor growth by cutting off its blood supply and an antimitotic agent (ABT-751) that has shown early promise in the treatment of pediatric neuroblastoma. In addition, an Abbott scientist will lead ...

Clinical Outcomes of Nonsmall Cell Lung Cancer Patients can Be Classified by New Algorithms

...th the drugs gefitinib and erlotinib, two tyrosine kinase inhibitors. The algorithm places patients into categories indicating good or poor survival before treatment with one of the drugs and is based on the pattern of a group of proteins in the patients blood serum. The authors developed the algorithm on...

"Pre-treatment Blood Test" A New Guide to Lung Cancer Therapy

... drugs known collectively as EGF receptor tyrosine kinase inhibitors, a step forward in the era of personali...herapy. In the case of the EGF receptor tyrosine kinase inhibitors (TKIs) gefitinib (Iressa) and erlotinib (Tarceva), studies have demonstrated a survival b...

Cytokine Resistance Contributes to Pathology of Type 2 Diabetes

...ulin receptor substrate 2 / phosphatidylinositol-3 kinase (IRS-2/PI3K), which was more of a mystery. One of the actions of diabetes is to create intracellular insulin resistance. Some of the cytokines that work on cells share the same pathways as the insulin receptor, Freund said. The study showed that ...

Researchers Identify New Genetic Risk Factors for Type 2 Diabetes

...in may affect the activity of the cyclin dependent kinase 5 (CDK5) protein, which stimulates insulin production and may influence other processes in the pancreas's insulin-producing cells, known as beta cells. In addition, excessive activity of CDK5 in the pancreas may lead to the degeneration of beta cells...

Researchers Make Headway in Treatment of Diabetic Retinopathy

...by inhibiting an enzyme in the body called protein kinase C beta (PKC beta), which is believed to contribute to the blood vessel damage that leads to the disease. This is the first time a drug has been shown to protect against the complication in a human clinical trial. According to Dr. Richard Insel, Exe...

ChemGenex Treats First Patient With Ceflatonin

...erant to treatment with two or more prior tyrosine kinase inhibitors (TKIs). The new study is designed to complement the ongoing registration-directed clinical trial in CML patients with the T315I point mutation and will recruit CML patients from chronic, accelerated and blast-phase disease states. Th...

High Dose Inhaled Corticosteroid Use for COPD Could Cut Risk of Lung Cancer

...hemoprevention, including micronutrients, tyrosine kinase inhibitors, and blockers or agonists of signaling pathways as reviewed. It is hoped, within the next decade, that chemoprevention of lung cancer in high-risk individuals (beyond smoking cessation) will be standard in pulmonary and primary care settin...

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