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Tag: "inhibition" at medical news

Skin Rashes Signifies Longer Survival in Cancer Patients

...ue to an inflammatory response as a result of EGFR inhibition in skin tissue, Wacker said. The analysis looked at two placebo-controlled, double-blind, randomized, Phase III clinical trials testing Tarceva in advanced non-small cell lung cancer and pancreatic cancer - studies which led to approval of the age...

Insulin Sensitizer- Energy Conserving Signal to Brain

... central nervous system and suggest that selective inhibition of the chemical in the brain may represent a novel therapeutic strategy for obesity and obesity-linked diseases, he added. White adipose tissue (WAT) is a major site of energy storage and plays an important role in energy balance, the researchers s...

Src Inhibitors in Breast Cancer Therapy

... via proteolysis. In line with this finding, Src inhibition was shown to impair estrogen-stimulated ER-alpha proteolysis. The data raise the possibility that for at least a subset of ER-alphanegative breast cancers, Src may stimulate estrogen-dependent ER-alpha degradation, resulting in a lack of ER-alpha det...

Eap1 in the Brain Regulates the Female Reproductive Cycle

...activated GnRH. The authors went on to show that inhibition of EPA1 expression in the rat hypothalamus delayed the onset of puberty and disrupted estrous in these animals. The data suggest that EPA1 is an important regulator acting within the brain and contributes to the control of female reproductive functio...

Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers

... Unfortunately, though, attempts to target Ras for inhibition in a clinical setting have proved unsuccessful. "We knew Ras was really important for cancer, but time after time it defied attempts to be inhibited in the clinic. So we decided, why not go after something that you can make a drug against that Ras a...

Boffins Find Evidence for Novel Brain Cell Communication

...e another, on the other hand. The excitation and inhibition take place because the activity of nerve cells leads to the release of particular chemicals, called neurotransmitters, which act as a classic means of communication between nerve cells, and lies at the base of most of current understanding of how the...

Alzheimers Disease Enzyme may Interfere With Brain Function

...eural activity, Kovacs explains. However, complete inhibition of BACE activity could interfere with the enzymes normal regulation of sodium channels, so therapeutic strategies using those inhibitors will need to be carefully designed....

New Genetic Studies Carried Out in Cancer Therapy

...de accumulation and initiation of apoptosis, while inhibition of this arrest, characterized by polyploidy, may suppress ceramide generation and promote cell survival. These data suggest that the taxane class of drugs may lack efficacy in tumors with high levels of chromosomal instability characterized by chro...

Researchers Reverse Mental Retardation Symptoms in Mice

...activity of PAK, Tonegawa said. "Strikingly, PAK inhibition also restored electrical communication between neurons in the brains of the FXS mice, correcting their behavioural abnormalities in the process," he added. "Our study suggests that inhibiting a certain enzyme in the brain could be an effective ther...

Research Shows Way for Drug Therapy for Autism

... in normal individuals. "Our analysis shows that inhibition of PAK activity reverses the structural abnormalit...XS had already taken hold in the mice. "That PAK inhibition can reverse pre-existing symptoms of FXS is very good news for future design of drugs for treating f...

Surface Logix Commences Phase 2a Clinical Trial of SLx-2101 in Raynaud's Disease

...ead to the development of digital ulcers. "PDE-5 inhibition holds promise in several cardiovascular indications, though many disorders such as Raynaud's are currently not addressed by marketed PDE-5 inhibitors," commented Paul Sweetnam, Ph.D., Chief Scientific Officer of Surface Logix. "We used our novel chem...

Role of Protein in the Development of Prostate Cancer Identified

...d form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 may prove to be of therapeutic use in the treatment of prostate cancer, depending on the stage of the tumor....

Combining NSAIDs With Chemotherapy May Improve Cancer Therapy

...nticancer activity was mediated through cell cycle inhibition and induction of apoptosis (cell suicide) and was ...or S phase activities like DNA repair. Celecoxib's inhibition of E2F1 activity may be a reason for the drug's observed S phase-specific toxicity. Trask notes th...

Drink, Binge and the Genetic Link

...nism. It has been observed that there is a loss of inhibition in those with the variant genes, and this has lead to some of them externalizing their behavioral problem. Individuals with variants of this gene have demonstrated conduct problems and usually get into trouble with the law. Another neurotransmitt...

Brain Cells Activity: New Treatment Target for Psychiatric Diseases

...ent keep a healthy balance between excitation and inhibition of brain cells. Incidentally, these genes are also...that Neuregulin-1 and its receptor, ErbB4, promote inhibition at the site of inhibitory synapses in the brain by increasing release of GABA, a major inhibitory ne...

Calcium and Vitamin D Intake Lowers the Risk of Breast Cancer Before Menopause

...ro to interact with each other in promoting growth inhibition in breast cancer cells," they say. Since blood levels of these compounds decline with age, they would be more prevalent in younger, premenopausal women. "Further investigation is warranted to study the potential utility of calcium and vitamin D i...

FASgen Announces New Diagnostic Research Test for Steatohepatitis

...apeutic products to treat obesity by the selective inhibition of FAS and related targets. Identifying patients w...te new therapeutic products based on the selective inhibition of fatty acid biosynthesis. The Company has the exclusive license from Johns Hopkins to more than 15...

Astrazeneca's Investigational Cancer Therapies Revealed at ASCO

... at ASCO showed that treatment with AZD2281 led to inhibition of PARP functional activity in both surrogate and ...e study data presented today, biomarkers confirmed inhibition of Src in human cancers for the first time.Principal Investigator for the study(1) presented today a...

Taiwan Researchers Claim Cancer Therapy Alternative

...in 75 percent of the group, compared to 50 percent inhibition of tumor growths in mice treated with a-Galcer. Encouraged by the experiments, Dr. Chang Ya-jen, another researcher involved in the study, said the new compounds could be used to manufacture drugs that would "provide an alternative therapeutic appr...

Aspirin Therapy for Heart Disease Found More Effective for Men Than Women

...uses clotting. Aspirin works by causing platelet inhibition in the blood, which means that platelets cannot st...p together. Anything less than 40 percent platelet inhibition is considered aspirin resistant. "We really don't know the mechanism," Dorsch said. "It could be ...

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