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Tag: "inactivation" at medical news

Cancer Patients are at High Risk for Potential Drug Interactions

... Consequences of these interactions can range from inactivation of cancer-fighting medications to severely injuring or killing the patient. Rachel Riechelmann, M.D., of the Princess Margaret Hospital in Toronto, and colleagues gave 405 cancer patients a questionnaire about the medications they had taken in the ...

FDA Approves New Product to Treat Von Willebrand Disease

.... Alphanate undergoes two separate steps for viral inactivation to reduce the risk for transfusion-transmitted viruses. However, the potential risk for the transmission of blood-borne viruses, and theoretically variant CJD, while very low, cannot be totally eliminated. In clinical studies with Alphanate, 120 m...

New Strategy for the Treatment of CML

...sis, or programmed cell death, in association with inactivation of multiple survival signaling pathways. Notably, enhanced lethality occurred in CML cells displaying various forms of imatinib mesylate resistance, said Grant. “While the development of newer, more effective kinase inhibitors such as dasatinib for...

Targeting a Single Gene Could Inhibit Bone Decay and Stimulate Bone Growth

...eoblasts and osteoclasts. The study shows that the inactivation of gene Atp6v0d2 in mice results in dramatically increased bone mass due to defective osteoclasts as well as enhanced bone formation. These findings may provide some clarity into the regulation of bone metabolism and show that targeting the function ...

Key Gene Controlling Eye Lens Development Identified

...ene’s possible role in mouse eye formation because inactivation of Six3 significantly disrupted development of the area of the brain where the eye normally forms. The St. Jude team overcame this problem by taking advantage of Cre/loxP-technology, which allowed them to choose the time and place in which to remove ...

Computer Tool Predicts Effectiveness Of Microbicides

...redients into the tissues, as well as the chemical inactivation of virus by the microbicidal agent. The model is easily adapted to studying different active ingredients and delivery vehicles simply by changing the data entered, the researchers said. For example, researchers might specify the thickness of the ex...

Food Safety Extension Specialist Provides Spinach E. coli Advice

...d to kill pathogens," he said. "Secondly, chemical inactivation of the pathogens is difficult because of the product. Lastly, control over the animals that overfly, graze, slither, crawl, and are otherwise naturally present in a field is impossible. The outbreak in question could have come from something as simpl...

Human Embryonic Stem Cells Could Be Later Used In Therapeutic Cloning

...e of the critical epigenetic events leading to the inactivation of one X chromosome in female cells. Failure to establish a normal pattern of DNA methylation during embryogenesis can cause immunological deficiencies, mental retardation and other abnormalities such as Rett, Prader-Willi, Angelman and Beckwith-Wied...

Advance in Program for Development of Non-Intravenous Therapy for Hemophilia

...enous routes because of poor distribution or rapid inactivation of the molecule in the body. Therefore, potential non-intravenous therapy must be able to reach its target site quickly and effectively without being inactivated in the process. "We are very pleased by the progress to date in this collaboration wit...

Mouse Models To Determine The Cause Of Aggressive Leukemia

... cells triggers an aggressive form of ALL. Loss or inactivation of both Arf genes resulted in the multiplication o...and imatinib treatment is far less effective. This inactivation of Arf in ALL cells expressing the Bcr-Abl enzyme gives these cells a strong proliferative nature wh...

Internet Based Tool, BGEM To Help In Study Of Brain Development

...des adequate information about gene expression and inactivation at each of the four stages of brain development. These images are linked to the updated information about the genes, their location and function, in addition to the accurate DNA sequence. Scientific databases such as LocusLink, PubMed, Unigene and ...

Australian Snake Venom Can Arrest Bleeding During Surgery And Trauma

...n livers. The mass delivery of Factor X results in inactivation of specific human systems, resulting in death. QrxPharma, a pharmaceutical company is currently considering the initiation of clinical trials of the potential 'life-saving drug'. The study is the first extensive study conducted on genes responsible...

Gold Therapy- A Potential Treatment For Autoimmune Diseases

...peutic drug Cisplatin (contains platinum) produced inactivation of the Class II MHC molecules. Motivated by their finding, the researchers probed further into metal containing compounds and found that a special form of gold also possessed the remarkable property of Class II MHC molecule inactivation. The result...

Inactivation of Rad9 in Tumor Cells Would Be Advantageous In Cancer Therapy

...f Medicine and Barnes-Jewish Hospital said that // inactivation of mammalian Rad9 in Tumor Cells Would Be Advantageous In Cancer Therapy. Rad9 checks for DNA damage, and fixes dangerous breaks in the DNA double helix. It is active in telomeres which are the protective ends of chromosomes. Hence Rad9 has gaine...

Little Known DNA Repair Enzyme May Be A Tumor Suppressor Gene

...lymerases in their tracks. Research has shown that inactivation of this lesion-replicating enzyme in yeast leads to a dramatic decrease in the frequency of mutations induced by a wide range of DNA damaging agents. In this study, Dr. Wittschieben and his associates sought to determine pol zeta's key role in mic...

Researchers Develop Mouse Model Of Brain Tumor

...shown through the above-mentioned model that Ink4c inactivation collaborates with a mutation in a gene called Patched (Ptc1, a Shh receptor) to trigger the development of this tumor. "Preliminary data suggest that INK4c protein expression is diminished in a significant cohort of human medulloblastomas," says Dr. ...

Gene linked to colorectal cancer identified

...ical groups added to it, resulting in an unhealthy inactivation of the gene. "Given the high lifetime risk of colorectal tumor development in the U.S. population, it is reasonable to propose testing, to determine whether healthy persons with MGMT promoter methylation in normal colorectal [lining] are at higher r...

Nitric oxide involved in high blood pressure

High blood pressure causes inactivation of nitric oxide, a hormone involved in blood press...al called nitrotyrosine, a product of nitric oxide inactivation by reactive oxygen species....

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