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Tag: "humanized" at medical news

Roches Arthritis Drug Successful in III Stage Trail

...s and symptoms. Biologic Actemra (tocilizumab), a humanized monoclonal antibody works by a different mechanism than today's rheumatoid arthritis treatments. Actema is the first biologic to inhibit the interleukin-6, or Il-6, receptor. IL-6 is considered an important mediator of the acute inflammatory response...

Genetic Tests Could Help Decide the Right Anti-depressants

... to the health of neurons. Then he subjected these humanized mice to stress and found that they did not respond to Prozac with decreased anxiety. The clear implication is that people with this variant will not be able to respond to any SSRI, which requires normal neurotrophic-factor function to work. A psych...

New Antibody for EGFR Causes Lung Cancer Regression

...acellular part of the protein. Importantly, the humanized form of mAb806 (ch806) caused regression of lung tumors in both models of lung cancer. The data presented in this study therefore indicate that ch806 might provide a new therapeutic for the treatment of patients with lung cancer driven by mutant form...

Rheumatoid Arthritis and Sex Bias

...ww.interscience.wiley.com/journal/arthritis), this humanized mouse model may be valuable for not only studying ... sex hormone effects of the human disease, the new humanized mouse may provide a better model with which to study the pathogenesis and treatment of arthritis." ...

Hybrid antibodies to protect from small pox infection

...ted smallpox strain in humans and collecting these humanized antibodies from volunteers which can offer immunit...so contains the antibodies isolated from small pox humanized individuals containing the two antibodies 8AH7AL and 8AH8AL which effectively neutralized the virus....

Herceptin for Early Stage Breast cancer

...(anti-estrogen therapies). The Drug Herceptin is a humanized monoclonal antibody prepared for treating Her-2 positive patients but the drug is very costly and the Herceptin treatment is to be given for 1 year. Herceptin is approved for late stage breast cancer treatment but a new study conducted by Breast Ca...

Novel Actemra monotherapy in treating patients with early aggressive rheumatoid arthritis

...damage and destruction. Actemra (tocilizumab) is a humanized anti-human interleukin-6 (IL-6) receptor monoclonal antibody. A monoclonal antibody is used to denote antibodies derived from genetically identical group of cells, a clone. The novel mechanism of action of the antibody can eventually pave way for a n...

Transplanted heart made more acceptable by daclizumab

...on top of standard immunosuppression. The drug, a humanized monoclonal antibody, is directed against the interleukin-2 receptor, thereby inhibiting T-cell proliferation. Patients who were taken into the Study were either given daclizumab or a placebo. The primary endpoint was a composite of moderate or seve...

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