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Tag: "hematopoietic" at medical news

New Platform for Regulating Expression of Therapeutic Genes Unveiled

...in the mouse model and for improving the safety of hematopoietic stem cell gene therapy. The American Society of Gene Therapy is a professional non-profit medical and scientific organization dedicated to the understanding, development and application of gene and related cell and nucleic acid therapies and the p...

New Hope for Regenerative Medicine

... were able to functionally reconstitute the entire hematopoietic system of adult mice. Furthermore, the scientists ...ls contribute, long-term, to the function of their hematopoietic system. One issue in using uniparental ES cells for tissue transplants is their durability and saf...

'single–parent' stem cells to replace adult mice organ

...o McLaughlin, that uniparental cells could produce hematopoietic stem cells. In addition, McLaughlin's group found no evidence of disease linked to the transplanted cells. In another finding critical for any clinical approach using embryonic stem cells, the researchers were able to reproduce much of their findi...

Stem Cell Banking Evokes Mixed Response

...bilical cord. This blood is an excellent source of hematopoietic stem cells which can be further stored and used for transplantation needs. Currently there are private and public cord blood banks. While the public banks are generally used for everyone, private ones are meant for the families of the donors. ...

Graft-versus-Host Diseases can Be Predicted

...ersus-host disease is a complication of allogeneic hematopoietic cell transplantation, which results from recogniti...graft versus host disease might be predicted after hematopoietic cell transplantation. In the first paper “Prediction of Graft-Versus-Host Disease by Gene-Express...

Researchers Explore the Effect of Engineered Immune Cells on HIV

...ells. Collaborators on his project are targeting hematopoietic stem cells -- the bone marrow cells that form bloo...s to be making sure lentiviral vectors target only hematopoietic stem cells, and not other types of cells, to achieve the desired targeted delivery. With a group of...

Molecular ‘Marker’ on Stem Cells Aids Research, Perhaps Therapis

...ow; the vast majority of bone marrow is made up of hematopoietic stem cells, which give rise to blood and immune cells. Dr. Rita Perlingeiro, assistant professor in the Center for Developmental Biology and of molecular biology, said detecting SSEA-4 will aid in singling out the mesenchymal stem cells, or MSCs, f...

Stem cell transplant recipients face significant risk of second cancer

... study has highlighted that patients who receive a hematopoietic stem cell transplant (HSCT), face a considerable risk of developing a second cancer, especially// if they are older during the time of the transplant or have received stem cells from a female donor. A peer-reviewed journal of the American Cancer S...

"Tribbles" Protein Implicated in Leukemia

...specific and overwhelming effect when expressed in hematopoietic stem cells, the cell type that gives rise to all e... mice engineered to express Tribbles-2 (Trib-2) in hematopoietic stem cells developed AML. They also found that Trib-2 inhibited C/EBP?, another protein that is freq...

Partial-match cell transplants for kids with resistant leukemia

... irradiation and ATG was the use of haploidentical hematopoietic stem cell transplantation (HaploHSCT) for children, which was previously pioneered by St. Jude investigators. Before this technique, only matched transplants from a genetic twin or from a matched, unrelated donor could be used, since unmatched donati...

Gene May Regulate Cellular Aging

...Dr. David Scadden, studied the role of p16INK4a in hematopoietic stem cells, which proliferate continuously during the adult lifespan and produce massive amounts of new blood cells on an hourly basis. Their results suggest that p16INK4a is the molecular basis for an old-age 'signal' previously observed in blood st...

Princess Kiko Offers To Donate Cord Blood For Leukemia Transplantation

...n a better manner. Umbilical cord blood contains hematopoietic stem cells that produce red and white blood cells. These cells are valuable to leukemia patients. To date, there have been 3,161 cases of cord blood transplantation in Japan. RAS...

In-Vivo Gene Therapy Technique to Cure XSCID in Basset Pups

...lant from a normal donor designed to replenish the hematopoietic stem cells that are capable of constantly renewing...CID dogs with the hope of correcting the defective hematopoietic stem cells within the patient. The therapy completely restored immune function in three of the four...

Nervous System Plays Role In Stem Cell Regulation

...odstream. The blood and immune cells come from the hematopoietic stem cells. The immune systems are being restored by hematopoietic stem cell transplants for patients who undergo intensive cancer therapy as at present. Donor cells a...

Combination growth factors for Stem cell proliferation

...at the new combination increased the production of hematopoietic cell in the lab by more than 30 times. The researchers feel that increased production of stem cells would increase the transplantation rate and would also help in gene targeted therapy in which the gene of interest could be injected into the vector v...

Novel Technique Can Enhance Stem Cell Multiplication By 30 Fold

... in the stem cell population was observed when the hematopoietic cells were mixed with purified IGF-2. Abundant expression of two other factors called Angiopoietin-like 2 (angpt12) and Angiopoietin-like –3 (angpt13) were also found. When these components were mixed with IGF-2, a 30-fold increase in the stem cell...

Calcium Receptor Vital For Stem Cell Migration to Bone Marrow

... such as sickle cell anemia and thalassemia. The hematopoietic stem cells that have a remarkable regenerative capacity play a very critical role in the production of blood cell components such as the red blood cell, white blood cell and platelets. It also governs the production of various cellular components of ...

Stem Cell Treatment For Children With Brain Injury To Be Initiated

...ating into bone, cartilage, fat cells, neurons and hematopoietic stem cells capable of differentiating into blood cells. This would be followed by processing of the mesenchymal stem cells at Baylor College of Medicine and introduction into the injured child by an intra-venous injection. The entire process would ...

Biopsies Of Human Skin And Bone Marrow Support T Cell Development

...t the development of functional human T cells from hematopoietic precursor cells in the absence of thymic tissue. The researchers from Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women’s Hospital, Harvard Institutes of Medicine, Boston, Massachusetts, USA, found that newly gen...

A Novel System For Clinical Banking Of Umbilical Cord Blood

...19 August 2005)Umbilical cord blood is a source of hematopoietic progenitor cells and is used as an alternative to ...diseases. Because of the limited number of CD34+ hematopoietic stem cells present in UCB units and of the elevated costs of cryopreservation, it is of paramount im...

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