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Tag: "genomic" at medical news

The Importance of Junk DNA

...ne, found that some of the remaining 96 percent of genomic material might be important in the formation of bo...ng sequences. The research team studied a repeated genomic sequence called SINE B2, which is located on the growth hormone gene locus, the gene related to the ...

New Genetic Studies Carried Out in Cancer Therapy

...tumor will respond to treatment,using a functional genomic screen. Resistance to chemotherapeutic drugs is the primary cause of treatment failure in patients with metastatic cancer. Dr. Julian Downward from the Cancer Research UK London Research Institute and colleagues used RNA interference to directly ex...

RNA Play a Vital Role in Gene Activity

...f evidence suggesting that RNA is more than a mere genomic servant. RNA is best known for ferrying protein-...elves were determined. "I like to think of it as genomic scuba diving," said Rinn of the new experiments. The tiling array allowed him to map the boundaries ...

Prof Samir K Brahmachari, Dr MRS Rao Jointly Win Bio-medical Research Award

... of colon cancer and is credited to have initiated genomic approaches towards understanding various biological processes in both normal and diseased conditions. The biennial Ambedkar Centenary Award was instituted in 1991-92 by the ICMR as part of the birth centenary celebrations of Dr B R Ambedkar....

Treatment of Premature Babies, Opossums Could Help

... part in an international study led by the leading genomic research centre, the Broad Institute in Boston. Dr Belov was involved in the painstaking task of comparing the genetic information revealed about the opossum's immune system with that of humans by using highly complex algorithms, or mathematical fo...

Researchers Find Estrogen Governs Genes That Affect Aggression

...mone decreases aggression in long-day mice through genomic pathways. The researchers say that their findings may have many implications for humans....

New Mouse Model to Aid in Cancer-causing Genes Hunt

...important characteristics of human tumors, such as genomic instability, pieces of chromosomes breaking apart and reattaching, which lead to defects like missing genes or extra copies of genes some of which are key to the tumors formation. As part of the study, researchers used gene knockouts to develop mic...

Global Heartbeat Control Suggests Therapy for Beating Heart Failure

...the researchers employed a powerful combination of genomic tools to identify the gene promoters to which ERR and bind in the adult mouse heart and to investigate changes in gene and protein expression when levels of ERR are manipulated. That investigation provided evidence that ERR and control most aspects...

Genome of Botulism Bacterium Revealed

...ility of this tool should revolutionise functional genomic studies in clostridia." This remarkable, stable genome demonstrates the wide range of strategies used by bacteria to enhance their chances of survival. For the Clostridia, these range from the approach used by C. difficile - long-term interaction w...

Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory

...rain. A protein complex called chromatin causes genomic DNA to compress much like a telephone cord shortens as it coils. When chromatin loosens, genes associated with memory can activate more easily. Previous studies have shown that the protein CBP causes chromatin to relax, thus facilitating gene activat...

Parkinsons Disease can Be Predicted by Metabolic Pathway

...a major paradigm shift from single gene studies to genomic pathway studies of complex diseases, says Demetriu... a constellation of variants within a well-defined genomic pathway, he says. When we looked at the axon guidance pathway in Parkinsons disease in this way, it ...

Scientists Identify Critical Gene Factor in Heart Development

...rol more than one gene. Dr. Srivastava's team used genomic studies to examine all of the genes that were turned on or off by the loss of miR-1-2. This information will help to determine the global picture of microRNA control. "Our results show that even small changes in microRNA dosage can have large effe...

Drug Used to Prevent HIV Transmission from Mother to Child Damages DNA

...or its metabolites into DNA, oxidative stress, and genomic instability may be the contributing factors to the pattern of mutations observed in the study, according to the authors. They conclude, "The cumulative mutagenesis data suggest that infants exposed transplacentally to AZT may be at increased risk for...

Drug Used to Prevent HIV Transmission from Mother to Child Damages DNA

...or its metabolites into DNA, oxidative stress, and genomic instability may be the contributing factors to the pattern of mutations observed in the study, according to the authors. They conclude, "The cumulative mutagenesis data suggest that infants exposed transplacentally to AZT may be at increased risk for...

New Genetic Biomarkers Could Predict Coronary Heart Disease

...ing to each other, which would otherwise result in genomic instability. Telomeres are also thought to be the "clock" that regulates how many times an individual cell can divide. Telomeric sequences shorten each time the DNA replicates. When the telomeres reach a critically short length, the cell stops dividi...

Gene Test Shown to Measure Heart Function After Transplant

New research suggests a genomic test may provide detailed information on how well a transplanted heart is performing.// The gene expression profiling (GEP) test, known as the Allomap test, is currently used to detect the absence of heart transplant rejection instead of routine inva...

Diagnosis Of Sjogren's Syndrome Possible Using Saliva

...tients with pSS. In addition, the proteomic and genomic profile of these markers reflects the damage to gl...independent technologies. The saliva proteomic and genomic biomarkers collectively will have a positive beneficial diagnostic value on the clinical detection o...

Genetics Might Engineer Path to Successful Aging

...and her husband, Jeffery Vance, are bringing to UM genomic research in autism, tuberculosis, infectious diseases, cardiovascular disease, cancer, multiple sclerosis and other diseases. ''And we're looking into the genetics of successful aging,'' said Pericak-Vance. ``Why some people live so long and well a...

Irregular Heartbeat Linked to Genetic Mutation

...tient. The sequencing of KATP channel genes, using genomic DNA extracted from the patient's peripheral white blood cells, revealed a genetic mutation. The discovery of the genetic mutation's role in contributing to atrial fibrillation may ultimately improve physicians' ability to identify patients who have...

Abnormalities in Eye Movements and Attention can Predict Schizophrenia

... the illness but do not have it – for more intense genomic study. That sort of research may help scientists pinpoint the gene or genes that cause schizophrenia. “The study of schizotypic individuals offers a unique perspective on what might cause the illness,” Lenzenweger explained. “It provides a clearer ...

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