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Tag: "genome" at medical news

Menin Gene Mutation made Insulin Secreting Cells to Proliferate

...precise timing in ‘cutting’ the Men1 gene from the genome of knock-out mice. They showed that within seven days of excising Men1, pancreatic islet cells proliferated in the mice. Previously, other labs could only see proliferating islet cells after months of Men1 excision because they could not precisely ti...

Cell Survival Depends on Chromosome Integrity

...ls are well known to lead to cancer. “Maintaining genome integrity is crucial for cell survival,” says Jef Boeke, Ph.D., Sc.D., the report’s senior author, a professor of molecular biology and genetics and co-director of the High Throughput Biology Center of the Institute for Basic Biomedical Sciences at H...

New Technique Identifies Unknown Genetic Mutations That Can Cause Cancer

...raditionally, cancer-gene hunters have scanned the genome looking for mutations that trigger out-of-control cell growth. Druker tried this approach, but found it wanting. "We were doing some high-throughput DNA sequencing, and we weren't really finding much," he said. Instead, the team added tools from th...

A high BMI may not determine obesity, researchers say

...d genetic tools to identify locations on the mouse genome that influence adiposity (amount of body fat), overall body size and bone structure. Applying an analytical technique called "structural equation modeling" to the genetic and physical characteristics of mouse inbred crosses, the scientists went beyon...

Joint Center for Molecular Modeling Instituted by Burnham Institute for Medical Research & UC San Diego

...rstanding of information gathered// from the human genome project. Rich with $2.1 million funding available to them over a three year period, this consortium, under the name Joint Center for Molecular Modeling, will seek to provide adequate support to scientists from Burnham and UCSD's Computer Science and ...

NHGRI Aims To Sequence Primate Genomes

...NIH) has announced that it would be sequencing the genome of Northern// white-cheeked gibbon (Nomascus leucogenys). The main aim is to sequence the genome of primates along the evolutionary tree that will give some clue to human health and disease. Comp...

A New Approach towards Anti-Cancer Drugs

...crucial role in conserving stability by preventing genome mutation. Hence he said that if the protein is allowed to perform its function without the interference of the MDM2 protein then this would prevent many types of cancer....

Malaria Truths Discovered By Einstein Researchers

...erting any gene of interest into the P. falciparum genome to gain biological information that could lead to more effective treatments. “This opens up a whole new window into the genetic manipulation of this lethal parasite,” says Dr. William Jacobs, Jr., who is a Howard Hughes investigator and professor of...

Obsessive-Compulsive Disorder Is Familial

... Four years ago, the U-M and UIC team published a genome scan from young OCD patients and their parents tha...lies. They're also looking at other regions of the genome that might contain gene variations that are more common in people with OCD. Contact: Kara Gavin k...

Mice Model for Parkinson's disease Shows Promise

...gene called TFAM is automatically deleted from the genome in dopamine nerve cells only. Without TFAM, mitochondria cannot function normally. The so called respiratory chain is compromised and energy production decreases severely in the dopamine cells. The new mice are born healthy from healthy but genetic...

New Findings on Autism Research

...cal causes of autism. To find regions of the human genome that contain autism genes, the researchers scanned the DNA of 169 families that had at least two siblings who met the strict criteria for autism. They also scanned the DNA of another 54 families that, in addition to having individuals with strictly d...

Creation of Cytomegalovirus Vaccine by an Innovative Method

...y introduce selected genes from human CMV into the genome of mouse CMV in the laboratory. The result was a novel form of CMV virus that infected human cells well enough that it might trigger an immune response but not well enough to sustain an infection. "It should be possible to develop a safe and effect...

Innovative Method for Creating a Human Cytomegalovirus Vaccine Outlined

...y introduce selected genes from human CMV into the genome of mouse CMV in the laboratory. The result was a novel form of CMV virus that infected human cells well enough that it might trigger an immune response but not well enough to sustain an infection. “It should be possible to develop a safe and effect...

Human Embryonic Stem Cells Could Be Later Used In Therapeutic Cloning

...d demethylation of particular DNA sequences in the genome are known to have profound effects on cellular behavior and differentiation. For example, DNA methylation is one of the critical epigenetic events leading to the inactivation of one X chromosome in female cells. Failure to establish a normal pattern ...

The Dengue Virus Unplugged

...ract during RNA replication, shaping the viral RNA genome into a circle. Gamarnik's team published those fin...l RNA, the scientists created copies of the dengue genome with minor changes that would alter its structures. The mutated RNAs were then inserted into mosquit...

New Studies On Zebrafish Could Aid in Treating Birth Defects

...nd develop outside the body. Much of the zebrafish genome has been sequenced, allowing researchers to identify human versions of zebrafish genes and vice versa. These qualities make the zebrafish exceptionally handy in studying the complex relationship between genes and nutrition during development, a puzzl...

Genes And Aging

...of this study was to identify regions of the human genome that contributed, along with lifestyle factors, to...ubjects were male, half were female. Using a novel genome survey method, scientists compared the DNA of the study sample with that of 100 young adults, aged 1...

Researchers from Emory University Undertake A New Genetic Mapping

...2003, scientists had published the completed human genome sequence based on the DNA obtained from about a ha...eported that the mapping had showed that the human genome is made from billions of chemical building blocks that appear in pairs. They explained that these bl...

A Protein from Primate may Save Humans from HIV !

...in gene would be incorporated into the chloroplast genome of tobacco cells before the plants grow. Daniell has developed a similar approach to growing anthrax vaccine in tobacco plants. An inexpensive way to produce the drug with only a small amount of tobacco would help to make it accessible in areas suc...

Genetics Of Mental Retardation

... The research was based on the hypothesis that the genome contains hotspots that are prone to instability an...ure of these regions that, during replication, the genome can become "confused" and duplicate, reverse, or delete itself within these regions. Source: Eurek...

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