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Tag: "gene" at medical news

AutoGenomics Addresses TB Crisis With a Genetic Drug Resistance Test

... resistant TB by directly detecting the resistance gene in the mycobacteria". MDR-TB (Multidrug Resistant TB) is a type of mycobacterium tuberculosis that is resistant to at least the two main first-line TB drugs - isoniazid and rifampicin. XDR-TB is MDR-TB that is also resistant to three or more drugs....

Brain Inflammation A Friend for Alzheimer's Patients

... class of viruses known as lentiviruses for use in gene therapy. The team used a lentivirus to boost levels of IL-1 beta in select brain regions of its engineered mouse, then applied the technology in mice specially designed to develop Alzheimers disease. The mice developed normally for six months. Then...

Mouse Model Points to Strategy for Treating Rare Muscle Disease & Kidney Disorders

... which is caused by a specific mutation in the GNE gene known as M712T. Numerous other GNE mutations can c...reated a transgenic mouse model in which M712T GNE gene mutation was introduced into a strain of mice. However, the researchers were surprised to find that,...

New Platform for Regulating Expression of Therapeutic Genes Unveiled

...tic genes, which will have major implications for gene and cell therapy, was presented today at the 10th ... Therapy (ASGT) in Seattle. Carefully regulating gene expression is crucial to the success of gene and cell therapy. For many applications, gene transfer ...

Novel Delivery Method of Insulin Gene to Combat Juvenile Diabetes Developed

A safer method to deliver the insulin gene to diabetes patients using nanoparticles, was pres...d that gut K-cells can be induced with the insulin gene to produce insulin in response to meal ingestion in a pattern comparable to normal insulin productio...

Gene Therapy a Better Alternative to Viagra Please

... those suffering from erectile dysfunction (ED) - gene therapy. And it could be effective far longer than the pills. Human and animal trials suggest gene therapy could offer a credible alternative to the current treatments available. A University of Pitt...

Astrazeneca's Investigational Cancer Therapies Revealed at ASCO

...r mechanism, in tandem with a defective DNA repair gene like BRCA1 or BRCA2, is thought to lead to double-...f Src in tumours. Src was the first cancer-causing gene to be discovered in the 1970s. Src kinases are a family of molecules that play an important role in ...

Gene Responsible for Blindness in Infants and Children Identified

... international team led by MUHC has identified the gene that causes Leber Congenital Amaurosis (LCA). LCA ...ildren and then study them so that we can then use gene therapy to rescue their vision. Working with an international team of researchers including Drs. A...

Researchers Identify Genetic Mutations for Hereditary Diffuse Gastric Cancer

...astric cancer (HDGC) is caused by mutations in the gene CDH1, and is characterized by an increased risk fo...y to assess the frequency of mutations in the CDH1 gene and whether these mutations occurred due to independent mutational events or common ancestry. The ...

Recurrent Gliomas: Vorinostat Shows Anti-cancer Activity

...as treated with vorinostat prior to surgery, and a gene and protein analysis of their resected tumors was ...nfirmed increase in histone acetylation and showed gene changes indicating that vorinostat reaches the glioblastoma tumors and interferes with the target pa...

Cell Genesys Reports Additional Data From Phase 2 Clinical Trial of GVAX Immunotherapy for Pancreatic Cancer

...er subsidiary, Ceregene, Inc., which is developing gene therapies for neurodegenerative disorders. Cell Genesys is headquartered in South San Francisco, CA and has its principal manufacturing operation in Hayward, CA. Statements made herein about the company, other than statements of historical fact, in...

HIVmirror, LLC Launching Breakthrough Genetic Product for HIV Positive Consumer

...isease progression and more specifically, if their gene types are associated with slowing the progression ...tson, a genetic scientist, was working on the CCR5 gene and believed that the HIV positive public should have access to this information. He and Awad collab...

Dystonia Awareness Week: 4 -11 June, 2007

... other hand, not everyone who inherits an affected gene succumbs to the disease. Dystonia can also occur in individuals because of spontaneous mutations. Experts suspect that a problem in the basal ganglion (a part in the brain that controls movement) predisposes an individual to dystonia. Secondary o...

Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory

...n CBP causes chromatin to relax, thus facilitating gene activation required for memory formation. The enzy...minister the drug during this critical period when gene expression is required.,he added. Wood and his colleagues discovered that the protein CBP must be...

Effects of 'starvation Hormone'-Newly Identified in Low-carb Diets

... the brain.Maratos-Fliers team examined changes in gene activity occurring in mice fed a high-fat, low-carb diet for 30 days. Their comprehensive genetic screen of the animals, which lost weight on the special diet, turned up FGF21.'We saw a dramatic increase in FGF21 in the livers of the mice [on the die...

New Findings in Fragile X Mental Retardation Protein

...rdation is mainly caused by a mutation in the FMR1 gene on the X chromosome, leading to the loss of FMRP, ... of the first two labs to show that FMRP regulates gene expression at the mRNA stability level, Huang added. The idea is to find the mechanisms underlying t...

GAB2-A New Alzheimers Gene Identified

...nd their collaborative partners, suggests that the gene called GAB2 modifies an individuals risk for Al... before it strikes To date, the most significant gene found to predispose an individual to late onset Alzheimers (LOAD) has been APOE4. In this latest stu...

New Insights into Antimalarial Drug Resistance

... construct, and then express in yeast, a protozoan gene that contributes to such resistance. The gene they laboriously constructed over a two-year period is believed to be the largest synthetic one ever...

Loss of Stem Cells Correlates With Premature Aging

...versity of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the bodys response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types ...

Largest Ever Study of Genetics Behind Common Diseases Published

... inflammatory bowel disease. For the first time, a gene called PTPN2 has been found which links the two autoimmune diseases. The study also confirmed the importance of a process known as autophagy or self eating in the development of Crohn's disease. Autophagy is responsible for clearing unwanted mater...

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