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Tag: "gene" at medical news

A new century of Alzheimer's disease research

...early, before age 65. A breakthrough came when the gene that produced the AB fragments (amyloid-beta precu...ally engineer a mouse to express a mutation of the gene that controls tau production, and in 2000 they reported in Nature Genetics that the “tau” mouse deve...

Researchers Discover How Cancer Evades the Immune System

...cca Sadun used real-time PCR (rtPCR), a high-speed gene amplification technique, to screen tumours to iden...n of immune cells, and over-production of B7-H4, a gene whose protein product inhibits immune activation. The human colorectal cancers, however, showed va...

Stem Cells from Human Fat Tissue to Hunt for and Kill Cancerous Tumours

Boffins have developed a new gene therapy by using 'suicide genes' derived from mese...in the lab, used a retrovirus vector to insert the gene cytosine deaminase into the cell. The gene can convert a less toxic drug, 5-fluorocytosine (5-FC)...

Gene Variation Increases the Risk of Lung Cancer

...te the response to inflammation. Variations in the gene may lead to greater expression of the protein, which is more likely to turn on the cascade and sustain the damaging effects of inflammation. Over time, the constant damage of inflammation could lead to genetic damage and cancer, Engels said. The re...

Variation in Genes Related to Inflammation Increase Lung Cancer Risk

... the response to inflammation. Variations in the gene might lead to greater expression of the protein, which is more likely to turn on the cascade and sustain the damaging effects of inflammation. Over time, the constant damage of inflammation could lead to genetic damage and cancer. Inflammation is p...

Major Gene Link Seen to Childhood Asthma

A newly-discovered gene boosts the risk of childhood asthma by as much as ...d single-nucleotide polymorphisms, in their ORMDL3 gene than healthy counterparts. "We are confident that we have discovered something new and exciting ab...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

...rs say that they found a recurring mutation of the gene AKT1 in breast, colorectal, and ovarian cancers. The AKT pathway is among the most commonly activated cellular pathways in human cancers and members of this pathway are among the most frequently targeted for new cancer drug discovery efforts. T...

New Oncogene for Brain Cancer

An overexpressed gene found at the scene of a variety of tumors is impli...the National Academy of Sciences. Just because a gene is associated with cancer doesnt mean that its actually causing cancer. In this paper we show for th...

Skin Cancer can Be Triggered by P53 Mutation

...each year. Mutations in the p53 tumor suppressor gene have been implicated in tumor formation: some give rise to a loss-of-function whereas the majority of mutations result in a gain-of-function. In the first of these two studies, Dennis Roop, Carlos Caulin, and colleagues from Baylor College of Medic...

New Asthma Gene Identified

A gene that is strongly associated with a risk of develop...ildren with this marker had higher levels of a new gene called ORMDL3 in their blood, which occurs in higher amounts in children with asthma. The presence o...

The Hospital Superbugs

...ou need to be able to inactivate, 'knock-out', the gene responsible, and then see if the bacterium can sti...o. Our breakthrough ClosTron technology now makes gene knock-out very quick and easy. Once we know what factors are important we should be able to develop...

Gene Expression in Blood may Hold Clues About Chronic Fatigue Syndrome

Researchers have linked gene expression with the disease process that lies behi...esearch, scientists examined six million pieces of gene expression information to study the differences in gene expression patterns in the blood of 15 indiv...

Protein That Absorbs Lipids may Provide Future Weight-loss Strategies

... may apply to humans. Humans with mutations in the gene that makes CD36 don't seem to process fat normally... studies into humans, where variations in the CD36 gene are common. She, however, admitted that before so doing, she wanted to learn more from animal studie...

British Woman Who Has inherited Breast Cancer Wants to Spread Awareness

...ironically, died of old age at 110, who passed the gene on. He had children with several different women a... with breast cancer, you don't really need to do a gene test. Women in this category are offered regular screening and some opt to have a bilateral mastecto...

First Genetically Engineered Maize Resistant to Maize Streak Virus Produced in S. Africa

...oup at the University of Cape Town mutated a viral gene that encodes a protein that the virus needs to replicate itself and inserted it into maize plants. When the virus infects one of these transgenic maize plants, the mutated protein, which is expressed at a high level, prevents the virus from replicati...

Afro- American Women Have More Aggressive Breast Cancer

...higher rates of expression of the growth-promoting gene Ki-67 and higher expression of a tumour inhibiting...at enable us to plan how we want to pursue further gene studies." The triple negative status of a tumour is particularly important, affecting the use of w...

Size and Position of Floral Anther Plays a Vital Role in Pollination

... animals are also classified on the basis of their gene sequences. These two areas of systematics often ...and plant biologists have begun to understand that gene sequences alone cannot explain diversity. Within the last few years, scientists have begun to iden...

Boffins Identify Gene That can Protect Humans from Nephronopthisis

...) and the University of Michigan have identified a gene that can protect humans from nephronopthisis (NPHP...s. The team has discovered that mutations in the gene GLIS2 can lead to nephronopthisis (NPHP) in both humans and mice. Mathias Treier and his group at...

Mutated Gene Zaps Pancreas Cancer in Mice

A mutated gene named Bik can shrink or kill tumors in the pancrea...or one of the deadliest human cancers The mutant gene named Bik expresses a protein that forces cancer cells to kill themselves, researchers from The Univ...

New Therapies for Kidney Diseases

...) and the University of Michigan have discovered a gene that protects us against a serious kidney disease ... Nature Genetics they report that mutations in the gene cause nephronopthisis (NPHP) in humans and mice. NPHP is a disease marked by kidney degeneration dur...

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