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Human Genome Project Achieves Technological Triumph

The completion of rough draft sequence of the human genes is a major scientific milestone and was achieved on 26.06.2000. The project began more than 10 years ago to map out almost 35 billion chemical letters that make up the recipe of human life. This breakthrough is expected to revolutionize the practice of medicine by paving the way for new drugs and medical therapies...Specific sequences...

Bypass Heart Surgery Performed Without General Anesthesia

A minimally invasive direct coronary artery bypass (MIDCAB) procedure was performed at Pittsburgh while the patient was awake. The operation was done under thoracic epidural anesthesia. This approach may help in discharging the patient early from the hospital. Dr. Zenati from the team of doctors who performed the surgery said that patients who are operated in this way may not have to go to the in...

PRIMARY PULMONARY HYPERTENSION GENE DISCOVERED

The discovery of the gene associated with the inherited form of primary pulmonary hypertension (PPH) by Drs. Jane H. Morse of Columbia University and James A. Knowles of the Columbia Genome Center is indeed a major breakthrough. .. .. ..Their study, funded in part by the National Heart, Lung, and Blood Institute at the National Institutes of Health and published in the September issue of the Amer...

Blood Cells Capable of Regenerating Liver

..Livers can be regenerated using stem cells from blood -- an important discovery that means patients may be able to grow their own liver transplants using bone marrow. This adds to a growing body of evidence that stem cells, known as "master cells" because they can produce a variety of different kinds of cells, might one day be manipulated to create custom-grown organ transplants. .. .. .."The...

Potential New Cancer Gene Identified

A Johns Hopkins University research team has discovered a new ..family of genes that contributes to the process of malignancy, ..shedding new light on the abnormalities that give rise to the aggressive childhood cancer, Burkitt's lymphoma - as well as ..lymphoma, leukemia, prostate, ovarian, lung, and breast cancer. .. .. ..Characterized by rapidly growing abdominal tumors, Burkitt's ..lymphoma i...

Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.

Researchers at the University of Texas Health Science Center at ..San Antonio have successfully regrown mouse teeth in a petri dish from single mouse cells - and they think humans are next. They ..hope to push the research in the direction where they could take ..initial tissue from a [human] patient, put it in a culture dish and grow a tooth for them.To accomplish this seemingly futuristic feat,...

New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered

This technology essentially renders the body transparent and will allow physicians to determine whether gene therapies reach targeted cells and work as they should. .. .."The technology is expected to help patients with cancer and other illnesses, such as cardiovascular disease. The discovery is outlined in the August 2000, issue of the journal Nature Medicine. UCLA researchers plan to test the t...

Evidence Links Protein Damage to Neurodegenerative diseases like Parkinson's and Alzheimer's

Neurodegenerative diseases - including Parkinson's, Alzheimer's, Diffuse Lewy body disease, and Multiple System Arophy - are collectively called synucleinopathies. Most commonly they become symptomatic due to a deficiency of a specific neurotransmitter - in the case of Parkinson's it is dopamine. When the neurons that produce these chemicals die or become impaired, which occurs with oxidation, th...

General Anesthesia Safe For Children On Ketogenic Diet Suffering From Epilepsy

Epileptic children have always been ostracized as children of a lesser God. The physical, mental, moral and social ramifications of these hapless children are beyond words. One stumbling handicap in the surgical treatment of such children was the feasibility of administering General Anesthesia to these children. In many cases the anesthesia times ranged from 1 to 10 hours with procedures rangi...

Controversial deal on public access of the human genome map

While it is customary to...

Crowning glory of 2000!!! Cracking of the genetic code is top of tops

With the New Year elbowing out the old year it is time to reflect on the good old year and all the research work of 2000. And when we do that the first and foremost medical breakthrough, which comes to our mind, is the cracking of the genetic code. Almost all the top ten lists released by every one connected with the world of medicine features this remarkable feat in a prominent place and a major...

Doctors needed urgently in Gujarat

The quake-devastated state of..Gujarat in India is now slowly coming to terms with the full fallout of the..calamity. While different news channels and papers are busy increasing the..death toll by the thousand in every other bulletin, the state government and..the central government are now faced with the unenviable task of clearing the..problems at hand- the hospitals are crammed with patients...

Gene linked to early puberty in girls

A study conducted in the United States of America has zeroed in on the culprit behind the falling age of attaining puberty. A gene has been isolated which is said to be the cause for girls attaining puberty as early as 8- 10 years. However the most widely held explanation for this is growing childhood obesity, intake of rich foods and lack of physical activity...Also scientists were keen on the r...

Breast cancer treatment to be determined by gene test

Women newly diagnosed with breast cancer, may opt for mastectomy over breast-conserving lumpectomy if they test positive for a breast cancer gene mutation, researchers said California on Monday. ..About 5% to 10% of all breast cancers are caused by an inherited genetic susceptibility. The majority of these cancers are linked to mutations or alterations in two genes, BRCA1 and BRCA2. It is estimat...

Negligent doctors asked to cough up 3 lakhs for death of patient

In a judgement that might stir up another controversy, pitting the doctors against the consumer activists, negligent doctors in Kerala have been asked to pay three lakh rupees as compensation to the family of a pregnant woman who died due to aftershock of spinal anesthesia...The issue of doctors coming under the umbrella of consumer protection act has been a very controversial one with legal lumi...

Indian Doctor granted US patent on organ regeneration

Dr. Balakrishna Ganapat Rao Matapurkar, from Maulana Azad Medical College, New Delhi has created history of sorts by winning the first patent on organ regeneration from the American patent office for his technique in successfully regenerating / repairing organs in human beings. ..A few weeks ago the American patent office granted him a patent on this technique. Dr. Matapurkar was able to regener...

Gene Therapy shows promise in treating Hemophilia

Researchers at Beth Israel Deaconess Medical Center reported in the current New England Journal of Medicine that an experimental Gene Therapy method has safely introduced new genes into six men suffering from hemophilia. This method shows signs of helping these men fight the disease by producing the blood clotting protein they lack. None of the patients suffers side effects even after one year...

New Laser Techniques cure degeneration of the eye

Latest Laser techniques are being developed on a daily basis. One of these latest laser techniques is helpful in the treatment of those suffering from a degenerative eye condition. This degenerative condition cause blood vessels to grow underneath the retina and leak fluid, causing scarring and loss of vision. ..Eye specialists have come up with a new therapy called the Photodynamic Therapy, whic...

E Merck introduces Livogen Z with zinc sulphate

E Merck has launched Livogen Z, in the market with zinc sulphate.Livogen Z is one of the three versions of the trademark haematinic drug Livogen.Livogen was an old product of Glaxo India with Rs 3 crore revenue.Glaxo India Ltd has sold its Livogen brand to E Merck India Ltd. ....According to a notification sent to the // Bombay Stock Exchange (BSE), Glaxo India signed a memorandum of understandi...

Gene HPA-2 Met linked to cardiac arrest

Men who die early from heart disease are more likely to have a specific variant of a blood clotting gene...Researchers in Finland carried out tests on 500 men who had died suddenly, many of whom had had a cardiac arrest. ....They found that, in men younger than 55, a gene variant known as HPA-2 Met was 2.2 times more common than in the general population.// ....The gene is one of many involved...

Estrogen lowers cancer risk

Italian scientists have found that women had about a 20 percent lower chance of developing cancer if they used oral contraceptives. This new research bolsters the theory that the female hormone estrogen might protect women from colorectal cancer. .... Dr. Carlo La Vecchia, who led the study said "For a while now we have suspected that estrogen in the pill could protect against bowel cancer a...

Genetic influence in menopause

Genes generally control menopause in women. Many women will be aware that they probably started their menopause at around the same age as their mother or sister. But the link between the menopause and genetics has not been established by scientific evidence till now. ....Researchers in Utrecht and Wageningen in the Netherlands have collected data from 243 non-twin sisters in 118 families already...

Human gene number increases

A new estimate puts the paltry number of human genes more than 30 per cent higher. At around 30,000, the gene number estimated from the human genome sequence seemed scanty compared with the mustard weeds' (25,000) and the fruitfly's (13,000). Michael Cooke and colleagues at the Genomics Institute of the Novartis Research Foundation in San Diego, California compared the two gene sets and found tha...

Gene clue to antibiotics

A new bacterial genome sequence suggests a route to new antibiotics, and other valuable drugs. As bacteria learn to evade antibiotics, even minor infections can become a major threat. There is an urgent need for new antibiotics to tackle resistant bacteria.// ....Antibiotic resistance is a growing public health problem. Seventy per cent of known antibiotics come from the soil bacteria Streptomyce...

Genes for lung disease

Researchers in the US have found that genes contribute to the risk of chronic lung disease, along with smoking. Chronic obstructive pulmonary disease (COPD), the name given to chronic bronchitis and emphysema - is very disabling, because it leads to increasing shortness of breath. It's linked with gradual destruction of lung tissue and smoking is a major cause of the problem.// ....However, not...

Genetics and cholesterol levels

According to a twin study reveals that cholesterol levels are controlled by both genes and dietary factors. People with high blood cholesterol are often advised to go on a low-fat diet - or to take cholesterol-lowering drugs. It's known that reducing fat intake can reduce cholesterol levels. But there is also a genetic condition called familial hypercholesterolaemia (FH) which leads to high chole...

The tall gene

Over 4cm of men's height is due to the combination of just two genes, according to a new study undertaken at the University of Melbourne.The research, published in the Journal of Clinical Endocrinology and Metabolism this week, identifies one gene on chromosome 15 and one on the Y chromosome as contributors to height in men. These genes may also help explain why men are taller than women.// ...."...

Gene therapy - Aim to improve blood flow

Heart disease often means that areas of the heart muscle become poorly supplied with blood - this can lead to both painful angina attacks, and to heart attacks. If blood vessels could be encouraged to grow to reinforce the supply to the heart muscle, this could drastically improve quality of life. In diabetes, this is a frequent complication, and can lead to tissue death, and wounds which either...

Gene therapy restores sight

US scientists report they have successfully used gene therapy to restore sight to animals with a rare inherited form of blindness. ....A team of scientists led by Jean Bennett, at the University of Pennsylvania, reported their success in this month's Nature Genetics.Their experiment involved dogs with Leber congenital amaurosis (LCA), a form of blindness, that also affects human infants and for w...

Genesis of SUPAC

Scale-UP and Post Approval Changes (SUPAC) is an integral part of pharmaceutical product development but till a few years ago, no guidance was available, to assure a smooth scale-up operation. US FDA was the first regulatory body to address this issue. // ..Any pharmaceutical product developed by R&D team has to undergo various stages of scale-up from ‘laboratory-scale’ to ‘pilot-scale’ to ‘pr...

Uncovering a gene for oesophagal cancer

Scientists are close to uncovering a gene that may influence the risk of oesophagal cancer. ..A family in Liverpool, England, is helping Cancer Research Campaign scientists learn more of the genetic basis of cancer of the oesophagus. Twenty one members of this family have died of this cancer over five generations. The disease affects those who also have a mild skin disorder called tylosis. .. //...

Smoking can depreciate intellegence

Smoking in old age appears to be linked to intellectual impairment over the age of 64, research has found. ..A team from the Institute of Psychiatry in London carried out a community survey of an area of England ....They studied more than 630 people aged 65 and over. Smoking and drinking habits were recorded at the beginning of the study. The volunteers' intellectual powers were also assessed. Af...

Generic drug costs remain shackled

Price controls for generic drugs in primary care are likely to remain unchanged for the next year as the european government considers how best to supply the NHS. In 1999, a severe shortage of non-brand name medicines resulted in a 12.5 per cent increase in the cost of prescription drugs for the NHS, significantly higher than the 8 per cent average increase in previous years. // ....Pharmaceutic...

New gene for hairloss

Researchers have found a normal role for a gene that causes two rare hair-loss disorders when it is disabled.Gone are the days when scientists were finding it diificult to treat ordinary baldness. So far, even with the new work, there is no evidence of a direct link between the hairless gene and typical baldness. In fact, this new study does not explain why the gene causes the rare hair-loss diso...

Estrogen Does Not Prevent Recurrent Strokes

Despite some past evidence that hormone replacement might lower stroke risk in older women, new research shows that estrogen therapy does not protect women from recurrent strokes and may instead carry some risks. The findings add to growing evidence that hormone replacement therapy does not have the cardiovascular benefits doctors once believed. // ....Many doctors have long thought hormone repl...

Gas Masks Don't Always Fit an Emergency

Before the national anxiety over bioterrorism drives you to buy a gas mask at the nearest army surplus store, take a deep breath and brace yourself for what experts say about them -- most of it is not good. One could never know where the exposure is; you'd have to wear the mask at all times. //Even if you could stand to do that, the risks to your health would probably be higher than the likelihoo...

Collagen improves voice quality in Parkinsonism

According to surgeons, injecting collagen into the vocal cords improves voice problems in Parkinson's disease. One of the important symptoms of Parkinson's disease is the deterioration in voice quality experienced by some patients. This problem is known as hypophonia, and is caused by muscle rigidity and other abnormalities in the area of the voice box or larynx.// ....People with hypophonia sou...

Genetics helps in attacking cancer

According to a new study, a trial of a new anti-cancer drug interacts with specific genes, which may help refine future treatments. Ceflatonin, a natural product, is being tested as an anti-cancer treatment. Meanwhile, the US company ChemGenex is looking at the effect of the drug on the genes that are activated in cancer. They find that specific genes and cellular pathways are affected by ceflat...

Gene Therapy Destroys Pancreatic Cancer Cells

Pancreatic cancer is among the deadliest of cancers, affecting many people a year and having an extremely low survival rate. Pancreatic cancer is the most aggressive cancer and there are few palliative treatments. Using a new two-pronged attack, researchers were able to destroy deadly pancreatic cancer cells in the test tube and in lab animals. // ....The work was led by Dr. Paul B. Fisher, a pr...

Gene Treatment for Heart Disease

For the first time, there is reason to believe that a gene-based treatment for heart disease may truly work. The treatment -- which triggers growth of new blood vessels in hearts with severe hardening of the arteries -- may provide a viable new option for thousands of patients suffering with heart disease.// ....Treatment options for people with heart disease range from drugs to surgical procedu...
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