Key Signaling Molecules in New Teeth Formation Identified
...identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche, us...nals from the adjacent mesenchymal tissue regulate epithelial stem cells and form a complex regulatory network with epithelial signals. They also show that spat...Research in the Origin of Microtubules
...ing ("plus") ends of microtubules in human retinal epithelial cells with a fluorescent molecule, videotaped their growth and carefully followed the tracks back to their origin. "We show that not only the centrosome, but the Golgi also makes microtubules," Kaverina said. "And unlike centrosomal microtubules, w...Novagali Pharma Presents Phase III Clinical Trial of Vekacia(R) for Vernal Keratoconjunctivitis
...ischarge, papillae, limbal infiltrates and corneal epithelial disease), there was a statistically significant difference between both concentrations of Vekacia(R) and the vehicle treatment (p=0.0386 and 0.0208 for the Vekacia(R) 0.05% and Vekacia(R) 0.1% treatment arms, respectively). Similarly, improvement in ...Study of Bacterial Pathogen may Give Insight to Cancer Development
... 'We found that Listeria actually provokes human epithelial cells (cells lining the small intestine) into inge...se of food poisoning. 'When Listeria contacts an epithelial cell, the bacterium causes changes in the cells cytoskeleton that allow the cell to swallow up the b...Master Regulatory Gene of Epithelial Stem Cells Identified
...generation process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 ge...Role of Protein in the Development of Prostate Cancer Identified
... in prostate carcinoma compared to normal prostate epithelial cells, and TRPM8 has been suggested as a specific ...only mature, differentiated human prostate primary epithelial luminal cells express functional plasma membrane TRPM8 (PM-TRPM8) and that prostate cancer cells pos...Flash-heating Inactivates HIV in Breast Milk: Study
...ants in solid foods and formula can compromise the epithelial lining of a baby's digestive tract, making it easier for viruses to pass through. For this reason, WHO guidelines have recommended that after six months of exclusively breastfeeding, HIV-positive mothers wean their babies as soon as other foods are...Stem Cell Therapy Could Provide Cure for AMD in Five Years
... of the retinal support cells the retinal pigment epithelial cells (RPE). The rods and cones (the photoreceptors) in the retina, which are the light sensitive cells, depend for their survival on the normal functioning of these cells, and so failure of these cells leads to progressive loss of vision. In addi...Master Regulatory Gene of Epithelial Stem Cells Identified
...generation process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 ge...New York City Plans to Promote Circumcision
...cumcision the penile shaft and glans develops more epithelial keratinization, a process which makes the penis less susceptible to viral invasion. The WHO endorsement had come in the wake of studies done in Uganda, Kenya and South Africa. In the trials circumcision was shown to lower a man’s risk of contracti...Canandian Firm Announces Positive Results from Anti- Cervical Cancer Drug Trials
...s. They play a part in the development of cervical epithelial cancers. HPV is also associated with skin, oral and anal cancers. Helix BioPharma Corporation is a Canada-based firm specializing in cancer therapies. It says that its study showed a clinically efficacious response to the topical interferon tre...Cervical Cancer Vaccine Under Consideration in Europe
...s. They play a part in the development of cervical epithelial cancers. HPV is also associated with skin, oral and anal cancers. Gardasil, made by Merck and Sanofi Pasteur, offers protection against HPV types 16 and 18, which are responsible for 70% of all cervical cancers. They could also be effective agains...Scientists Re-grow Dental Enamel from Cultured Cells
...duce enamel. This group has recently shown that epithelial cells extracted from the developing teeth of 6-mon...ne). This crucial step boosts the number of dental epithelial cells available for enamel production. In the study being reported today, the researchers seeded ...Genetic Pathways to Curable and Incurable Forms of Pancreatic Cancer Identified
...ancreatic ductal adenocarcinoma, called pancreatic epithelial neoplasms, are tiny enough to be undetectable until the disease has progressed to the point where survival is almost nil. Moreover, these cells appear to be highly sensitive to the tumor-promoting properties of TGFb and thereby manifest a more aggres...Artificial Teeth Developed to Replace Missing Teeth
...ow they took two kinds of cells -- mesenchymal and epithelial cells -- that develop them into a tooth. They first grew each cell-type separately to make larger numbers of them and then injected them into a sticky protein called collagen. The tooth germ grew into a tiny tooth, about 1.3 mm long. The researc...Erroneous Laboratory Operation May Lead To a Cancer Drug
... She also found that PPAR-gamma had killed all the epithelial lining of the tumor cells. In the mice this compound killed colon tumor with no side effects. According to Schaefer, mode of action of PPAR-gamma is different from the current drugs. It attacks a section of cell cytoskeleton called tubulin. While ...Reactivated Genes Cause Tumors to Shrink (or) Disappear
...hers are looking at other types of cancer, such as epithelial (skin) cancer, in their mouse model, and they plan to see if the same approach will also work for tumor suppressors other than p53. Source-Eurekalert SRI...‘Sweet Revenge’ on Inflammatory Bowel Diseae
...rs called cytokines. These were used to repair the epithelial calls in the gut damaged by the disease, hence reducing the inflammation. While viruses and bacteria have always been used for delivering drugs the problem was being able to control the production. Says Carding “Current bacteria and virus delivery ...Selective Marker Found to Indicate Aggressive Form of Breast Cancer
... represent a selective biological marker for basal epithelial breast tumors, a highly aggressive cancer with sim...ncer before it has a chance to come back.' Basal epithelial tumors lack important molecular targets such as the estrogen receptor, progesterone receptor and Her...Selective Marker Found to Indicate Aggressive Form of Breast Cancer
... represent a selective biological marker for basal epithelial breast tumors, a highly aggressive cancer with sim...ncer before it has a chance to come back.' Basal epithelial tumors lack important molecular targets such as the estrogen receptor, progesterone receptor and Her...