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Tag: "enzymes" at medical news

A new century of Alzheimer's disease research

...r. (NSAIDs reduce inflammation because they target enzymes that are known as cyclooxygenases or COX, and classic NSAIDs, such as ibuprofen and indomethacin, nonselectively inhibit the two types of COX enzymes, COX1 and COX2.) But, again to their surprise, Drs. Golde and Koo found that many COX2 inhibitors a...

Translating Structure into Function

...exas A&M describes the first success decrypting an enzymes function from its structure. If their new strategy...t should become a potent tool to determine how key enzymes work in the body. And since enzyme action is crucial to disease, the technique opens an efficient ...

Parkinsons Disease Mechanism Identified

...hey had found that MPTP activates protein-snipping enzymes called calpains in mitochondria. They also found evidence that calpains, in turn, activate a cellular switch called Cdk5. The question, however, was how this abnormal activation ultimately kills neurons. In their new studies, the researchers analyze...

Obesity Drug may Hold Potent Cancer Treatments

...ntists analysed prostate cancer cells to see which enzymes were expressed at high levels to develop treatments to inhibit those enzymes to stop tumour growth. Researchers found that a protein known as fatty acid synthase was expressed...

Smoking Linked to Lower Parkinson's Disease Risk

...r cigarette smoke alters the activity of metabolic enzymes or competes with other substrates for these enzymes and thereby alters the production of toxic endogenous (dopamine quinones) or exogenous (MPP+) metabo...

First Drug for Post-traumatic Stress Disorder

...leagues show that inhibiting a kinase (kinases are enzymes that change proteins) called Cdk5 facilitates the extinction of fear learned in a particular context. Conversely, the learned fear persisted when the kinase's activity was increased in the hippocampus, the brain's center for storing memories. Cdk...

Experts Warn Against Side Effects of the New Weight Loss Drug

...st of $50 to $60 for a month's supply. Alli blocks enzymes that digest fat, preventing the body from absorbing about a quarter of the fat eaten. The undigested fat is then excreted. One study of Alli showed that dieters who took the drug along with diet and exercise over a year lost about three pounds more t...

Alzheimers Disease Enzyme may Interfere With Brain Function

... amyloid precursor protein (APP) is clipped by two enzymes BACE and gamma-secretase which releases the amyl...nd others showed that the BACE and gamma-secretase enzymes that release amyloid-beta from APP also act on the beta2 subunit of neuronal sodium channels. The cu...

Alzheimer's-associated Enzyme Linked to Seizures

...udies have shown that the BACE and gamma-secretase enzymes also work on the beta2 subunit of neuronal sodium channels. Sodium channels comprise an alpha subunit, which forms the channel's body, and one or two beta subunits that checks the activity of the channel. Voltage-gated sodium channels transmit sign...

Genetic Tests Could Help Decide the Right Anti-depressants

...ts. Nearly all drugs are metabolized by a group of enzymes that vary greatly in activity from person to person. If patients have a genetic mutation that results in either deficient enzyme activity or none, they would be likely to have serious side effects if exposed to the drug that is metabolized by the e...

Excessive Use of Cosmetics Leads to Adverse Effects on the Body

...tick gets into your mouth it is broken down by the enzymes in saliva and in the stomach. But chemicals get straight into your bloodstream, there is no protection," he said. Caution over using outdated lipstick and mascara have also been issued by the Royal College of Optometrists which considers that such ...

Research Studies on Molecular Switches of Gene

...ther clue to how CREB might activate the genes for enzymes that make glucose in the liver, while activating different genes in the brain that are key to learning and forming memories. A long-term implication of this work is that one day it might be possible to manipulate CREBs co-factors to treat disease. ...

Modified Drug Therapy for Alzheimers Disease

...ective, meaning it does not appear to affect other enzymes important to brain function or cause harmful side effects," Ghosh said. "It took years of work and evaluation of hundreds of molecules to achieve one with the strength and safety necessary for clinical potential." The trial, comprised of 48 healthy...

Make Up Unhealthy for Skin

...tick gets into your mouth it is broken down by the enzymes in saliva and in the stomach. But chemicals get straight into your bloodstream, there is no protection. Warnings over using out-of-date lipstick and mascara have also been issued by the Royal College of Optometrists, which believes such items are a...

Protein Targets for Carcinogenesis

... now it was believed that the cooperation of three enzymes is needed to attach Ub to another protein: E1, E2 ...ate themselves by directly recruiting Ub-loaded E2 enzymes thus making E3 ligases dispensible. In their previous work Hoeller and Dikic showed that the ubiquit...

Ex-IITian-designed Alzheimer's Drug's Human Clinical Trials Begin

...ective, meaning it does not appear to affect other enzymes important to brain function or cause harmful side effects," Professor Ghosh said. "It took years of work and evaluation of hundreds of molecules to achieve one with the strength and safety necessary for clinical potential," he added....

Researchers Devise New Compound to Treat Fungal Infections

...cid. Leucyl-tRNA synthetase is one of a group of enzymes called aminoacyl-tRNA synthetases that attach the correct amino acid to each tRNA. Some of these enzymes have two main functional parts that link the amino acid to the tRNA, and a separate editing site tha...

Potential Cure for HIV Discovered

...ptimistic about their ability to design additional enzymes which would target other parts of the virus's DNA. However they warned that there were significant barriers to overcome before the enzyme could be used to help cure patients. "The most important, and likely most difficult, among these is that the...

New Engineered Drug Shows Promise in Treating Lymphocytic Leukaemia

...truct by triggering a cell mechanism that requires enzymes called caspases. This new agent, however, works through a mechanism that does not call for caspases. "This is exciting because it means that this agent may benefit patients who are resistant to other CLL drugs," says co-author Natarajan Muthusamy,...

RNA Play a Vital Role in Gene Activity

...one clue: HOTAIR binds to and activates a group of enzymes called the Polycomb Repressive Complex 2 that modifies histones and helps them wind up the DNA. The researchers' interest is more than just theoretical. Polycomb proteins are improperly regulated in some types of cancers. HOX gene expression patter...

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