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Tag: "engineered" at medical news

Cleft Palate in Fetal Mice Prevented by Treating

Mice engineered to have cleft palates can be rescued in utero by injecting the mothers with a small molecule to correct the defect//, say scientists at the Stanford University School of Medicine and Lucile Packard Children's Hospital. In addition to shedding light o...

Enzyme Critical for Early Growth of Abdominal Aortic Aneurysms

...he point where surgery is necessary. Genetically engineered mice that lack the enzyme dipeptidyl peptidase I (DPPI) do not develop aortic aneurysms, researchers at Washington University School of Medicine in St. Louis report in the online edition of the Proceedings of the National Academy of Sciences U.S.A. '...

Scientists Uncover Cause of Antipsychotic Drug Weight Gain

...etite, the team gave clozapine to mice genetically engineered without a histamine receptor. Results? Peace. No heightened AMPK activity. “Histamine also has a long history as a suspect in weight control, but no one ever could put a finger on the exact link,” says Snyder. “The connection we’ve made between ...

Primitive Yeast Yields Secrets Of Human Cholesterol And Drug Metabolism

...d repeated their experiments in human kidney cells engineered to lack the human version of Dap1. As in yeast, the altered human cells accumulated cholesterol precursors and died because cholesterol is essential for cell survival. To show that Dap1 directly works with P450s and not through some other biochemic...

Inflammation can Lead to Cancer

...F finding comes from studies with mice genetically engineered to carry some of the genes of the human papilloma virus (HPV), a pathogen that is known to cause human cervical cancer. By comparing cancer progression in these mice compared with gene "knock-out mice" that lacked the antibody receptors normally acti...

C-Reactive Protein Induces Hypertension

... UT Southwestern researchers studied mice with an engineered gene for CRP that was under the regulation of a second gene responsive to changes in dietary carbohydrate intake. The levels of circulating CRP, which is produced by the liver, were directly manipulated by altering the mice's diets, and the effect on...

Researchers Discover Potential Targets To Reduce Risk Of Stem Cell Transplants

...st") as well as cancer cells. By using genetically engineered mice, the researchers have shown that inactivating the SHIP gene for just one week protects transplant recipients from acute GvHD. This protection is seen even when the graft contains extra immune cells to help the graft "take" or when the graft cell...

Mouse Study Suggests Anxiety Disorders Take Root in Infancy

...ers have known for some time that mice genetically engineered to lack the receptor for serotonin, a neurotransmi...he team then crossed the knockout mice with a line engineered to activate receptor expression in particular brain regions. The resulting line of double-transgenic...

Researchers Develop Resin Beads That Capture Mad Cow Disease Agent From Blood

... another filter containing the new resin particles engineered to capture the prion proteins. A group of disease-free hamsters was inoculated with the blood that passed through the leukofilter only. A second group was inoculated with the blood that passed through both the leukofilter and the prion-capture filter...

Natural Milk Protein Could Lead to Super Nutritious Foods

...on-Israel institute of Technology researchers have engineered a way to deliver health-promoting nutrients using protein //particles naturally present in milk as carriers. The breakthrough could lead to low fat or non-fat foods that contain nutrients now present only in fat-containing foods, and could be used to...

Genetics Might Engineer Path to Successful Aging

...fect could be dramatic. ``People are genetically engineered to live 100 to 110 years. They don't reach that because of chronic diseases. If we can prevent them, more people can live longer.'' Goldschmidt, formerly dean of medicine at Duke University, was instrumental in a $10 million deal that brought 20 Du...

Philadelphia Researchers Found A Novel Way To Fight Several Kind of Cancers

...mits a low energy gamma photon, but it can also be engineered to carry therapeutic radionuclides, which are lethal to cells in which TK is activated. Results of this study suggests that this strategy could be applied to other viruses associated with tumors, and that other drugs may potentially be used to act...

Vaccine Promising Against Hepatitis E

...The vaccine, made from moth cells infected with an engineered virus, was 96 percent effective for Nepalese Army soldiers who took all three doses. However, the disease wasn't widespread even in a group without the vaccine: only 7 percent got sick. The two-year test on 1,794 soldiers, almost all men, was repor...

Researchers Design Pulsed Mircrojet System to Deliver Protein Drugs Without Pain or Bruising

...rnia, has designed a novel pulsed microjet system engineered to deliver protein drugs into the skin without the...s of nerves and capillaries. The pulsed mircrojets engineered by the researchers combine high velocity (more than 100 meters per second) with very small jet diame...

Excessive RAMP1 Protein may Cause Migraines

...vigorously to the neuropeptide. The UI team also engineered mice to express human RAMP1 in their nervous syste..." he said. The study also suggests that the mice engineered to produce elevated levels of RAMP1 protein may be a good model for studying migraine and specifical...

Drugs to Tackle Anemia may Be Playing Dracula

...- the highest level of warning, to the genetically engineered drugs, erythtropoietins//, that are meant to counteract anemia. These drugs, such as Epo, are given to patients suffering from anemia caused by chemotherapy and kidney failure. They are hormone-based drugs, usually derived from kidneys. It w...

Lactococcus Strain may Offer End to Food Allergies

...ry is to use in "health" foods probiotics that are engineered to be better tolerance inductor. The big question is how will be accepted by the consumer." An estimated four per cent of adults and eight per cent of children in the 380m EU population suffer from food allergies, according to the European Federatio...

Inhaled Anesthetics Accelerate the Onset of Neurodegenerative Diseases Like Alzheimer's

...r's, so the animals in this study were genetically engineered to express the human protein responsible, called amyloid beta. "These mice develop a syndrome with many features of the human disease," explains Eckenhoff. Post-doctoral fellow and first author Shannon Bianchi, MD, exposed "middle-aged" Alzheimer mic...

Tissue Engineering for Craniofacial Reconstruction

...pt to repair or regenerate damaged tissue by using engineered tissue substitutes that can sustain functionality during regeneration and eventually integrate into the host tissue. The traditional tissue-engineering paradigm combines isolated cells with appropriate bioactive agents in a biomaterial scaffold. I...

Antioxidant Molecule Could Help Minimize Stroke-Linked Brain Damage

... out, the team tested the drug in mice genetically engineered to lack functioning CD36. "For these mice, treatment with SS31 after stroke had no effect," Dr. Cho says. "That suggests that this peptide is working via inhibiting CD36 pathways." The exact mechanism by which SS31 inhibits CD36 remains unclear,...

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