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Tag: "engineered" at medical news

Stem cells offer hope for muscular dystrophy

...oangioblasts into the arteries of mice genetically engineered to lack the alpha sarcoglycan gene -- in effect gi...ts turned up downstream. The team then genetically engineered the stem cells, putting in healthy versions of alpha sarcoglycan gene, and injected these into the m...

Rat joins list of cloned animals

...ts and mice used in labs are inbred or genetically engineered to have certain traits -- such as a weak immune system, or a tendency to cancer. So-called knock-out mice and rats lack certain, specific genes and are useful for finding out what an unknown gene does. Cloning such animals will guarantee they are...

New Hope for Kidney Failure

...research.// For the study, mice were genetically engineered to express higher-than-normal levels of the natural molecule hepatic growth factor (HGF) or another natural factor called parathyroid hormone-related protein (PTHrP). Both groups of mice developed normal kidney functions, thus allowing the researcher...

Hope for Patients With Kidney Failure

... new research.For the study, mice were genetically engineered to express higher-than-normal levels of the natural molecule hepatic growth factor (HGF) or another natural factor called parathyroid hormone-related protein (PTHrP). Both groups of mice developed normal kidney functions, thus allowing the researcher...

Regeneration of muscle

...differentiate into muscle cells. When stem cells engineered to express Pax7 proteins were injected into the mu... defective muscle. Researchers say this shows that engineered "donor cells" can differentiate in living tissue and help repair damaged muscle of recipient mice. W...

New Inhalation Anthrax Vaccine

...ecombinant protective antigen (rPA), a genetically engineered protein. Researchers say the powdered formula is more stable than the injected liquid version and can withstand wider temperature extremes, in more extreme conditions without refrigeration. The vaccine has not yet been tested in humans, but investig...

The Link Between Weight Loss and Heart Failure

...-related weight loss in mice that were genetically engineered to produce more than the normal amount of IGF-1. Thus researchers believe these findings can be used to help develop new treatments for congestive heart failure and other wasting conditions....

New insight for neuro-degenerative diseases discovered

...eins work. Researchers have observed genetically engineered mice producing prion protein without a glycophosphoinositol (GPI) cell membrane anchor that did not show the symptoms of scrapie disease when inoculated with scrapie prion protein. These mice had developed plaques in their brain, similar to those tha...

Arthritis and the Wnt Factor

...could be replicated in normal cells when they were engineered to express Wnt-7b, demonstrating the importance of Wnt-7b in the inflammatory response of RA. Wnt-7b was noticed to be strongly upregulated within joints at sites of disease manifestation mainly in synovium of RA but in synovium, cartilage, osteoph...

Language development linked to Foxp2 gene

...ficulties. In the research where scientists have engineered mice with Foxp2 gene mutations, results demonstrate that infant mice with the mutations emitted disrupted ultrasonic vocalizations when separated from their mothers. The set of mice, which had severe form of mutations of the gene, had the most proble...

Developing a new vaccine using a new technology

... isolated from non-human primates, which have been engineered to be non-infectious and capable of efficiently delivering genes expressing HIV proteins to the immune system. IAVI will play a role in contributing technical expertise and funding and thus form a joint R&D team together with GSK. Members of the tea...

Scientist discover secrets of ageing

...ons. Researchers who had worked with genetically engineered mice that ages faster, have said that the symptoms of aging is more emphatic in some critical cells that are adult stem cells and hence are required for replacing the dying cells. This may lead to impairment of the regeneration process of the bone ma...

New Discovery May Help Treat Infertility

...rove ovulation rates in mice that were genetically engineered to lack estrogen receptor beta. The estrogen receptor beta is one of two estrogen receptor proteins which mediate the effects of estrogen hormones and are present throughout the female reproductive tissues. The new data indicates that this receptor p...

Surgery using gene therapy for Alzheimer’s patient

...k place on April 5 involved implanting genetically engineered cells into the brain of a 60-year-old woman from O...s, skin cells taken from the patient herself, were engineered to produce a substance called nerve growth factor (NGF). NGF is known to help restore connections be...

Gene in Melanomas

...tigative Oncology in Sweden found that genetically engineered mice with a mutation in the gene, known as Cdk4, were more likely to develop melanomas when exposed to cancer-causing agents. Their results appear in the latest issue of the Proceedings of the National Academy of Cancers.// Seventy four per cent of ...

Molecule aids fight E. Coli Infections

...is view, team member Pascal Mantruelli genetically engineered a group of Drosophila with a mutated version of PGRP-LC. Indeed, these flies were much more susceptible to E. coli infection than were their normal counterparts, the researchers observed. "The next question to ask is whether this protein plays a rel...

Biotech drug causing anemia-EPREX

... human recombinant "erythropoietin", a genetically engineered drug, has recently been found to cause a potentially life-threatening anaemia among patients who have been administered with this drug. This drug introduced in the late 1980s and is used to treat patients with kidney disease. //The disease, called Pu...

Obesity Hormone -' Leptin' may treat Metabolic Disorder

...er team found that 4 months of injections with the engineered leptin boosted patients' blood levels of the hormone, cut their triglycerides and improved their blood sugar levels. And during leptin treatment, the women were able to discontinue on their diabetes therapies. The treatment "really made a big impact ...

Stem Cells Could Replace Electronic Pacemakers

...blem. Animal studies have shown that genetically engineered heart cells from human embryonic stem cells could ...guinea pigs. The stem cells were first genetically engineered and then encouraged to become heart cells. Results show after the guinea pigs' own pace-making cell...

Brain Plays Vital Role In Maintaining Bone Density

...versity of Jerusalem experimented with genetically engineered laboratory mice whose ability to react to interleukin 1, a protein, has been known for many years, reports science portal EurekAlert. The researchers were able to demonstrate that the proper loss or generation balance in bone tissue is regulated by ...

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